A5044078252- Bat Biology and Ecology Studies
- Viral Infections and Vectors
- interferon and immune responses
- Genomics and Phylogenetic Studies
- Genetic diversity and population structure
- Environmental DNA in Biodiversity Studies
- Wildlife Ecology and Conservation
- Economic and Environmental Valuation
- Molecular Biology Techniques and Applications
- Chromosomal and Genetic Variations
- Viral Infections and Outbreaks Research
- Environmental Conservation and Management
- Animal Disease Management and Epidemiology
- Rangeland and Wildlife Management
- Neurobiology and Insect Physiology Research
- Rangeland Management and Livestock Ecology
- Geographies of human-animal interactions
- Protist diversity and phylogeny
- Conservation, Ecology, Wildlife Education
- Marine and fisheries research
- Climate Change and Geoengineering
- Wildlife Conservation and Criminology Analyses
- Environmental Philosophy and Ethics
- Ecology and biodiversity studies
- Poxvirus research and outbreaks
Stony Brook University
2021-2025
Smith College
2023-2024
University of Massachusetts Amherst
2014-2023
United States Fish and Wildlife Service
2014-2016
University of Connecticut
2015
Louisiana Department of Natural Resources
2015
Abstract High-quality and complete reference genome assemblies are fundamental for the application of genomics to biology, disease, biodiversity conservation. However, such available only a few non-microbial species 1–4 . To address this issue, international Genome 10K (G10K) consortium 5,6 has worked over five-year period evaluate develop cost-effective methods assembling highly accurate nearly genomes. Here we present lessons learned from generating 16 that represent six major vertebrate...
Zoonoses are infectious diseases transmitted from animals to humans. Bats have been suggested harbour more zoonotic viruses than any other mammalian order1. Infections in bats largely asymptomatic2,3, indicating limited tissue-damaging inflammation and immunopathology. To investigate the genomic basis of disease resistance, Bat1K project generated reference-quality genomes ten bat species, including potential viral reservoirs. Here we describe a systematic analysis covering 115 that revealed...
Abstract High-quality and complete reference genome assemblies are fundamental for the application of genomics to biology, disease, biodiversity conservation. However, such only available a few non-microbial species 1–4 . To address this issue, international Genome 10K (G10K) consortium 5,6 has worked over five-year period evaluate develop cost-effective methods assembling most accurate genomes date. Here we summarize these developments, introduce set quality standards, present lessons...
Abstract Comprising more than 1,400 species, bats possess adaptations unique among mammals including powered flight, unexpected longevity, and extraordinary immunity. Some of the molecular mechanisms underlying these includes DNA repair, metabolism However, analyses have been limited to a few divergent lineages, reducing scope inferences on gene family evolution across Order Chiroptera. We conducted an exhaustive comparative genomic study 37 bat one generated in this study, encompassing...
Abstract Background Studies in vertebrate genomics require sampling from a broad range of tissue types, taxa, and localities. Recent advancements long-read long-range genome sequencing have made it possible to produce high-quality chromosome-level assemblies for almost any organism. However, adequate preservation the requisite ultra-high molecular weight DNA (uHMW DNA) remains major challenge. Here we present comparative study methods field laboratory sampling, across classes different...
Abstract Bats carry viruses that can cause severe disease in other mammals. Asymptomatic infections bats suggest limited tissue-damaging inflammation and immunopathology. To investigate the genomic basis of resistance, Bat1K project generated reference-quality genomes ten bat species. A systematic analysis showed signatures selection immune genes are more prevalent compared with We found an excess gene adaptations ancestral Chiroptera many descending lineages, highlighting viral entry...
Abstract Sorex araneus , the Eurasian common shrew, has seasonal brain size plasticity (Dehnel’s phenomenon) and abundant intraspecific chromosomal rearrangements, but genomic contributions to these traits remain unknown. We couple a chromosome-scale genome assembly with transcriptomes discover relationships between molecular changes both traits. Positively selected genes enriched Fanconi anemia DNA repair pathway, which prevents accumulation of aberrations, is likely involved in...
Summary We generated a highly-contiguous, annotated genome of the Jamaican fruit bat, Artibeus jamaicensis, including germline immunoglobulin heavy chain (IGH) and light (IGL) loci to understand bat B cell receptor repertoires. The shares many structures features described in human loci. However, some are unique A. jamaicensis , an expansion cysteine-rich IGHV genes. To investigate relationship between IGH locus expressed receptors (BCRs), we sequenced BCRs wild-caught captive finding...
Abstract The genus Myotis is one of the largest clades bats, and exhibits some most extreme variation in lifespans among mammals alongside unique adaptations to viral tolerance immune defense. To study evolution longevity-associated traits infectious disease, we generated near-complete genome assemblies cell lines for 8 closely related species . Using genome-wide screens positive selection, analyses structural variation, functional experiments primary lines, identify new patterns adaptation...
The public trust doctrine (PTD) is the common law basis for governments to hold wildlife in benefit of current and future generations Americans. Wildlife as a resource foundation North American Model Conservation. We examine principles that underlie trustee’s role context PTD governmental responsibility. evaluate purposes needs human dimensions inquiry execution stewardship conclude research essential government fulfill its responsibilities trustee, particularly considering breadth often...
In late December 1973, the United States enacted what some would come to call "the pitbull of environmental laws." 50 years since, formidable regulatory teeth Endangered Species Act (ESA) have been credited with considerable successes, obliging agencies draw upon best available science protect species and habitats. Yet human pressures continue push planet toward extinctions on a massive scale. With that prospect looming, scientific understanding ever changing,
The U.S. Endangered Species Act (ESA) provides a framework for the protection and recovery of threatened endangered species their habitats in face anthropogenic threats. Genetic information has played role decision-making under ESA decades, most commonly informing taxonomy designation distinct population segments, though detection inbreeding also an early role. transition to genomic technologies improved precision resolution important genetic metrics at-risk species, such as diversity...
ABSTRACT The North American Model of Wildlife Conservation represents the key principles that in combination resulted a distinct form wildlife conservation United States and Canada. How to what extent captive cervid facilities comport with or conflict these has implications for conservation. Greatest threats appear be toward public ownership wildlife, allocation by law, policy decisions based on science. Captive have potential contribute erosion underlying could undermine support...
Comprising more than 1400 species, bats possess adaptations unique among mammals including powered flight, unexpected longevity given small body size, and extraordinary immunity. Some of the molecular mechanisms underlying these includes DNA repair, metabolism However, analyses have been limited to a few divergent lineages, reducing scope inferences on gene family evolution across Order Chiroptera. We conducted an exhaustive comparative genomic study 37 bat species encompassing large number...
Comprising more than 1400 species, bats possess adaptations unique among mammals including powered flight, unexpected longevity given small body size, and extraordinary immunity. Some of the molecular mechanisms underlying these includes DNA repair, metabolism However, analyses have been limited to a few divergent lineages, reducing scope inferences on gene family evolution across Order Chiroptera. We conducted an exhaustive comparative genomic study 37 bat species encompassing large number...
Abstract Studies in vertebrate genomics require sampling from a broad range of tissue types, taxa, and localities. Recent advancements long-read long-range genome sequencing have made it possible to produce high-quality chromosome-level assemblies for almost any organism. However, adequate preservation the requisite ultra-high molecular weight DNA (uHMW DNA) remains major challenge. Here we present comparative study methods field laboratory sampling, across classes different types. We find...
Comprising more than 1400 species, bats possess adaptations unique among mammals including powered flight, unexpected longevity given small body size, and extraordinary immunity. Some of the molecular mechanisms underlying these includes DNA repair, metabolism However, analyses have been limited to a few divergent lineages, reducing scope inferences on gene family evolution across Order Chiroptera. We conducted an exhaustive comparative genomic study 37 bat species encompassing large number...