A5090930319- Viral Infections and Vectors
- Bat Biology and Ecology Studies
- Viral Infections and Outbreaks Research
- Blood groups and transfusion
- Parvovirus B19 Infection Studies
- Virus-based gene therapy research
- Yersinia bacterium, plague, ectoparasites research
Stanford University
2024
The ability of multiple bat species to host zoonotic pathogens without showing disease has fostered growing interest in immunology, indicating ways immune systems may differ between bats and other vertebrates. However, interspecific variation immunological diversity among only begun be recognized. order Chiroptera accounts for over 20% all mammal shows extreme a suite correlated ecological traits, such that should not expected immunologically homogenous. Here, we review the evolutionary...
Summary We generated a highly-contiguous, annotated genome of the Jamaican fruit bat, Artibeus jamaicensis, including germline immunoglobulin heavy chain (IGH) and light (IGL) loci to understand bat B cell receptor repertoires. The shares many structures features described in human loci. However, some are unique A. jamaicensis , an expansion cysteine-rich IGHV genes. To investigate relationship between IGH locus expressed receptors (BCRs), we sequenced BCRs wild-caught captive finding...
The genetic locus encoding immunoglobulin heavy chains (IgH) is critical for vertebrate humoral immune responses and diverse antibody repertoires. Immunoglobulin T cell receptor loci of most bat species have not been annotated, despite the recurrent role bats as viral reservoirs sources zoonotic pathogens. We investigated structure function IgH across largest family, Vespertilionidae, focusing on big brown