A5043004174- Phytochemicals and Antioxidant Activities
- Antioxidant Activity and Oxidative Stress
- Vitamin C and Antioxidants Research
- Adipokines, Inflammation, and Metabolic Diseases
- Genomics, phytochemicals, and oxidative stress
- Bone Metabolism and Diseases
- Muscle metabolism and nutrition
- Bone health and osteoporosis research
- Adipose Tissue and Metabolism
- Bioactive Compounds in Plants
- Thermoregulation and physiological responses
- Diet and metabolism studies
- Nutrition, Genetics, and Disease
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiovascular Health and Disease Prevention
- Trace Elements in Health
- Blood Pressure and Hypertension Studies
- Plant biochemistry and biosynthesis
- Hormonal and reproductive studies
- Apelin-related biomedical research
- Nitric Oxide and Endothelin Effects
- Stress Responses and Cortisol
- Sirtuins and Resveratrol in Medicine
- Medicinal Plants and Bioactive Compounds
- Renin-Angiotensin System Studies
Georgia State University
2017-2025
University of Arkansas for Medical Sciences
2015-2022
Florida State University
2012-2021
Tallahassee Orthopedic Clinic
2016-2017
Oxidative stress and inflammation are central to the development of a number chronic diseases including cardiovascular disease previous research suggests that blueberry consumption may attenuate these processes. The present study investigated effects blueberries on blood biomarkers oxidative stress, inflammation, antioxidant defense in postmenopausal women with pre- stage 1-hypertension. In randomized, parallel-arm, double-blind, placebo-controlled clinical trial, 40 1-hypertensive aged 45...
Blackberry, raspberry and black polyphenols reduce angiotensin II-induced oxidative stress senescence of vascular smooth muscle cells.
Heart failure (HF) is a debilitating disease affecting >64 million people worldwide. In addition to impaired cardiovascular performance and associated systemic complications, most patients with HF suffer from depression substantial cognitive decline. Although neuroinflammation brain hypoperfusion occur in humans rodents HF, the underlying neuronal substrates, mechanisms, their relative contribution deficits remains unknown.
The solute carrier 30A ( SLC30A ) family of zinc exporters transports into the lumen intracellular organelles in order to prevent toxicity. We reported that formation tyrosine dimers is required for ZnT3 (zinc transporter 3) transport activity and targeting synaptic‐like microvesicles SLMVs PC12 cells / ZnT10 heterodimers. Here, we focused on determine role heterodimerization sorting ZnTs endolysosomal pathway. Using cell fractionation, immunoprecipitation immunofluorescence approaches,...
This study supports differences in microvascular endothelial function and nitric oxide (NO)-dependent vasodilation between women low hormone phases of two hormonal exposures men. However, when separated into subgroups exposure, during placebo pills oral contraceptive pill (OCP) use have greater NO-dependent than naturally cycling their menstrual phase These data improve knowledge sex the effect OCP on function.
Menopause leads to an increased risk for osteoporosis in women. Although drug therapies exist, increasing numbers of people prefer alternative such as dietary supplements, example, calcium, vitamin D, and collagen hydrolysates the prevention treatment osteoporosis. We have previously shown that a 3-month intervention using calcium-collagen chelate (CC) supplement was efficacious improving bone mineral density (BMD) blood biomarkers turnover osteopenic postmenopausal This study reports...
Strawberries may improve health of hypertensive postmenopausal women.
Accumulating evidence indicate that blueberries have anti-hypertensive properties, which may be mainly due to its rich polyphenol content and their high antioxidant capacity. Thus, we aimed investigate the mechanisms by blueberry polyphenols exert these effects. Human aortic endothelial cells (HAECs) were incubated with 200 µg/mL extract (BPE) for 1 h prior a 12 treatment angiotensin (Ang) II, potent vasoconstrictor. Our results Ang II increased levels of superoxide anions decreased NO in...
The present study examined the dose-dependent effect of vitamin E in reversing bone loss ovariectomized (Ovx) rats. Sprague-Dawley rats were either Sham-operated (Sham) or Ovx and fed control diet for 120 days to lose bone. Subsequently, divided into 5 groups (n = 12/group): Sham, Ovx-control, low dose (Ovx + 300 mg/kg diet; LD), medium 525 MD), high 750 HD) sacrificed after 100 days. Animals receiving MD HD had increased serum alkaline phosphatase compared Ovx-control group. Bone...
Quercetin (QCT) and citrulline (CIT) have been independently associated with improved antioxidant capacity nitric oxide (NO) production, potentially enhancing cardiovascular function exercise performance. This study aimed to evaluate the combined independent effects of QCT CIT supplementation on NO metabolites biomarkers in 50 trained cyclists undergoing a 20 km cycling time trial (TT). In randomized, double-blind, placebo-controlled design, forty-two male eight female were assigned + CIT,...
The purpose of this study was to investigate the effect oral contraceptive pill (OCP) phase on in vivo microvascular endothelium-dependent vasodilation and contributions nitric oxide (NO), cyclooxygenase (COX), endothelial-derived hyperpolarizing factors (EDHF). Participants completed two experimental visits random order, during 1) low 2) high hormone OCP cycle. Endothelium-dependent dilation assessed cutaneous microvasculature via local heating at four intradermal microdialysis sites...
Background and aims: Coronary microvascular dysfunction (CMD) is associated with adverse cardiovascular outcomes. CMD driven by endothelial vascular smooth muscle cell (VSMC) dysfunction. We aimed to test whether could be mitigated a plant-based diet (PBD) in an animal model of hypertension. Methods: compared 28- 40-week-old female normotensive Wistar-Kyoto spontaneously hypertensive (SHR) rats, maintained, from age 4 weeks, on control refined or PBD, comprised 28% fruits, vegetables, nuts...