A5000120239- Topology Optimization in Engineering
- Composite Structure Analysis and Optimization
- Manufacturing Process and Optimization
- Epigenetics and DNA Methylation
- Genetic Syndromes and Imprinting
- Engineering and Materials Science Studies
- Advanced Multi-Objective Optimization Algorithms
- Composite Material Mechanics
- Design Education and Practice
- Structural Analysis and Optimization
- Probabilistic and Robust Engineering Design
- Advanced Numerical Analysis Techniques
- Mechanical Engineering and Vibrations Research
- Cancer-related Molecular Pathways
- Cancer Research and Treatments
- Cellular and Composite Structures
- Signaling Pathways in Disease
- Virus-based gene therapy research
- Birth, Development, and Health
- Genomics and Rare Diseases
- Pluripotent Stem Cells Research
- Automotive and Human Injury Biomechanics
- Model-Driven Software Engineering Techniques
- Toxin Mechanisms and Immunotoxins
- BIM and Construction Integration
University of Wuppertal
2014-2024
Klinikum Fürth
2020
Université de Lorraine
2017
Genedata (Switzerland)
2014
University of Toronto
2012
Karlsruhe Institute of Technology
2011
Centre for Addiction and Mental Health
2004-2011
Charité - Universitätsmedizin Berlin
2002-2009
HAW Hamburg
2006-2008
Klinikum rechts der Isar
2008
Despite an enormous research effort, most cases of late-onset Alzheimer's disease (LOAD) still remain unexplained and the current biomedical science is a long way from ultimate goal revealing clear risk factors that can help in diagnosis, prevention treatment disease. Current theories about development LOAD hinge on premise arises mainly heritable causes. Yet, complex, non-Mendelian etiology suggests epigenetic component could be involved. Using MALDI-TOF mass spectrometry post-mortem brain...
This work is dedicated to the development of a technology for unbiased, high-throughput DNA methylation profiling large genomic regions. In this method, unmethylated and methylated fractions are enriched using series treatments with sensitive restriction enzymes, interrogated on microarrays. We have investigated various aspects including its replicability, informativeness, sensitivity optimal PCR conditions microarrays containing oligonucleotides representing 100 kb derived from chromosome...
In recent years, the field of epigenetics has grown dramatically and become one most dynamic fast-growing branches molecular biology. The amount diseases suspected being influenced by DNA methylation is rising steadily includes common such as schizophrenia, bipolar disorder, Alzheimer's disease, diabetes, atherosclerosis, cancer, major psychosis, lupus Parkinson's disease. Due to cellular heterogeneity patterns, epigenetic analyses single cells a necessity. One rationale that profiles are...
Abstract Data searchability has been utilized for decades and is now a crucial ingredient of data reuse. However, in industrial engineering essentially still at the level individual text documents, while finite element (FE) simulations no content-based relations between FE exist so far. Additionally, growth warehouses with increase computational power leaves companies vast amount that rarely reused. Search techniques data, which are particular aware problem context, new research topic. We...
The integration and analysis of large datasets in translational research has become an increasingly challenging problem. We propose a collaborative approach to integrate established data management platforms with existing analytical systems fill the hole value chain between collection exploitation. Our proposal particular ensures security provides support for widely distributed teams researchers. As successful example such approach, we describe implementation unified single platform that...
Recent work on embryonic stem (ES) cells showed that cell‐derived tissues and embryos, cloned from ES cell nuclei, often fail to maintain epigenetic states of imprinted genes. This deregulation is frequently associated with in vitro manipulations culture conditions which might affect the potential develop into normal fetuses. Usually, instability reported differentially methylated regions mostly growth‐related However, little known about stability genes function late organogenesis. Hence, we...
Abstract The majority of parts in modern car bodies is manufactured from sheet metal. Rarely these are fully stressed due to design space restrictions and complex requirements. usage tailor rolled blanks (TRB) enables the reduction thickness areas less loaded thus reduces part weight. Technically most metal potentially suited for application TRB. Economic circumstances like additional flexible rolling process technology-specific nesting constraints limit a subset parts. search best candidate...
The chloramphenicol acetyltransferase gene under the control of late E2A promoter adenovirus type 2 (Ad2) was introduced as transgene into B6D2F1 mouse strain with mixed genetic background and became extensively de novo methylated. methylation this pAd2E2AL-CAT (7-1A) regulated in a strain-specific manner apparently depending on site integration. Transmission 7-1A an inbred DBA/2, 129/sv, or FVB/N led to significant loss transgene, whereas C57BL/6, CB20, Balb/c backgrounds favored...