A5010268079- Child and Adolescent Psychosocial and Emotional Development
- Muscle Physiology and Disorders
- Single-cell and spatial transcriptomics
- Nutrition and Health in Aging
- Child Welfare and Adoption
- GDF15 and Related Biomarkers
- Cancer Genomics and Diagnostics
- RNA Research and Splicing
- Adipose Tissue and Metabolism
- Acute Myeloid Leukemia Research
- RNA regulation and disease
- Impact of Technology on Adolescents
- Genomics and Rare Diseases
- Neutropenia and Cancer Infections
- Muscle metabolism and nutrition
- CAR-T cell therapy research
- Human-Automation Interaction and Safety
- Traffic and Road Safety
- Infant Health and Development
- Urban Green Space and Health
- Attachment and Relationship Dynamics
- Genetic Associations and Epidemiology
- Urban Transport and Accessibility
- Social Media and Politics
- Child Abuse and Trauma
Kettering University
2023-2025
The Barbara Ann Karmanos Cancer Institute
2024
Wayne State University
2024
New York Genome Center
2024
New York University
2024
University of North Carolina at Chapel Hill
2023
University of Iowa
2020-2023
University of Arkansas at Fayetteville
2022
Duke University
2021
Duke University Hospital
2021
Understanding how cells respond differently to perturbation is crucial in cell biology, but existing methods often fail accurately quantify and interpret heterogeneous single-cell responses. Here we introduce the perturbation-response score (PS), a method diverse responses at level. Applied datasets such as Perturb-seq, PS outperforms quantifying partial gene perturbations. further enables dosage analysis without needing titrate perturbations, identifies 'buffered' 'sensitive' response...
This investigation examined whether the mode of locomotion matters in how 8-, 10-, 12-, and 14-year-old children (N = 91) judge dynamic affordances a complex perception-action task with significant safety risks. The primarily European American sample came from area Iowa City, were balanced for gender. same crossed single lane continuous traffic on foot bike (order counterbalanced) identical immersive virtual environments. We found that although 8-year-olds chose significantly larger gaps...
The perinatal period is a vulnerable time for the development of psychopathology, particularly mood and anxiety disorders. In study maternal anxiety, important questions remain regarding association between symptoms subsequent child outcomes. This examined depressive symptoms, namely social panic, agoraphobia disorder during perception behavior, specifically different facets temperament. Participants (N = 104) were recruited pregnancy from community sample. completed clinician-administered...
Reduced visibility for both drivers and pedestrians is a key factor underlying the higher risk of vehicle-pedestrian collisions in dark conditions. This study investigated extent to which adjust road crossing at night by comparing daytime nighttime pedestrian using an immersive virtual environment.Participants physically crossed single lane continuous traffic simulator. Participants were randomly assigned either or lighting condition. The primary measures size gap selected timing motions...
Understanding diverse responses of individual cells to the same perturbation is central many biological and biomedical problems. Current methods, however, do not precisely quantify strength and, more importantly, reveal new insights from heterogeneity in responses. Here we introduce perturbation-response score (PS), based on constrained quadratic optimization, at a single-cell level. Applied transcriptomes large-scale genetic datasets (e.g., Perturb-seq), PS outperforms existing methods for...
AbstractThe current study describes a preliminary evaluation of the Learning and Empowerment for Adoptive Families (LEAF) workshop. This workshop is offered to adoptive families enhance communication about adoption, cope with strong emotions, build social connection. The includes data from 26 participating parents 21 children. Participants' report adoption-related beliefs feelings, comfort discussing family protective factors were compared before after group using paired samples t-tests....
Attachment and Biobehavioral Catch-up (ABC) is a promising home-visiting intervention promoting sensitive caregiving secure parent-child attachment in families with young children. The goal of this study was to examine learning collaborative approach disseminating ABC community setting. Training outcomes (e.g., trainee completion, satisfaction, effectiveness training methods) parent behavior, beliefs, child socioemotional development) were examined. Eighteen practitioners participated the...
Sarcopenic obesity (SO) differentiates itself from sarcopenia and by exhibiting a more detrimental complex condition that increases the risk of mortality in aging individuals. obese individuals suffer greater physical disability muscle weakness than sarcopenic alone. In addition, altered cellular signaling regulates increased loss SO is largely unknown. Identifying key differentially expressed genes are important for future investigation creation therapeutics strategies aimed at attenuating...
Sarcopenic obesity (SO) is the metabolic condition of age-related muscle mass loss combined with an increased fat deposition which can lead to impaired function and disability. This a growing concern in North America as elderly population has grown modern medicine life expectancy average adult. SO alters skeletal maintenance basal preservation mass, function, integrity. not widely studied, better understanding molecular mechanisms altered cellular signaling play could pave way for future...