A5100397001- Luminescence and Fluorescent Materials
- Nanoplatforms for cancer theranostics
- Organic Light-Emitting Diodes Research
- Advanced Nanomaterials in Catalysis
- Molecular Sensors and Ion Detection
- Photodynamic Therapy Research Studies
- Conducting polymers and applications
- Photoacoustic and Ultrasonic Imaging
- Inflammasome and immune disorders
- Radical Photochemical Reactions
- Toxoplasma gondii Research Studies
- Porphyrin and Phthalocyanine Chemistry
- Organic and Molecular Conductors Research
- Covalent Organic Framework Applications
- Fluorine in Organic Chemistry
- Organic Electronics and Photovoltaics
- Immunotherapy and Immune Responses
- Luminescence Properties of Advanced Materials
- Analytical Chemistry and Sensors
- Advanced Biosensing Techniques and Applications
- Machine Learning in Materials Science
- Metal-Organic Frameworks: Synthesis and Applications
- Supramolecular Self-Assembly in Materials
- Optical Coherence Tomography Applications
- Random lasers and scattering media
Nankai University
2017-2025
Jilin University
2012-2025
Southern University of Science and Technology
2025
State Key Laboratory of Medicinal Chemical Biology
2019-2024
Soochow University
2012-2024
Zhoukou Normal University
2024
South China University of Technology
2024
Jining First People's Hospital
2023
Shandong University
2023
Tiangong University
2020-2022
Controlling the packing arrangements of dyes is a facile way tuning their photophysical and/or photochemical properties, thus enabling new sensing mechanisms for photofunctional tools. Here, we present general and robust strategy toward water-stable J-aggregated dye-templated nanoassemblies by incorporating an amphiphilic diblock copolymer stimuli-responsive dye as only two building components. An iodo-substituted boron dipyrromethene (BODIPY) was adopted template to direct self-assembly...
Abstract Transparent glasses are ideal and robust hosts for a range of emission centers, while the simultaneous manipulation temporal spectral characteristics remains tremendous challenge inorganic glasses. Here, development functionalization melt‐quenched transparent coordinate polymer with tailorable ultralong room‐temperature phosphorescence demonstrated. Dynamic modulation is achieved by utilization high molecular rigidity spin‐orbital coupling effects within glass systems. By...
Personalized porous scaffold materials for bone defect repair, with adjustable mechanical strength and porosity via 3D printing technology, have made significant strides in the tissue engineering. However, their ability to regulate angiogenesis processes at site remains constrained, hindering effective coupling of angiogenesis-bone regeneration. In this study, we incorporated Nb2C MXene as a photothermal agent enhancer both osteogenesis, embedded into poly (lactic-co-glycolic...
Abstract Developing electron‐deficient (hetero)arenes with optimized geometries and electronic properties is imperative for advancing n ‐type polymers organic devices. We report here the design synthesis of two chlorinated imide‐functionalized heteroarenes, namely chlorine‐substituted bithiophene imide (ClBTI) its fused dimer (ClBTI2). The corresponding show a near‐planar framework, appropriate frontier molecular orbital levels, good solubility. When integrated into thin‐film transistors,...
A general approach toward highly fluorogenic probes across the visible spectrum for various analytes offers significant potential engineering a wide range of bioprobes with diverse sensing and imaging functions. Here we show facile strategy that involves introducing new mechanism in boron dipyrromethene (BODIPY) dyes, based on principle stimuli-triggered dramatic reduction electron-withdrawing capabilities meso-substituents BODIPYs. The has been demonstrated to be applicable BODIPYs emission...
Endowing fluorogenic probes with ultrahigh contrast is essential to increasing the accuracy of fluorescence sensing and imaging. Phenolate-based D-π-A fluorophores (A-DOH) belong a big family have attracted attention in probe design. However, intrinsic dilemma weak intracellular emission traditional A-DOH resulted low during live cell Herein, we present general robust approach preparing novel bright NIR living cells based on unique halogen effects. The reported chlorinated fluorophore...
A unique photosensitizer with intrinsic endoplasmic reticulum-targeting ability and high hypoxia-tolerance was developed used as a versatile scaffold to construct an activatable theranostic agent for precise photodynamic therapy against solid tumor.
The currently available immune checkpoint therapy shows a disappointing therapeutic efficacy for glioblastoma multiforme (GBM), and it is of great importance to discover better checkpoints develop innovative targeting strategies. discovered metabolic ecto-5-nucleotidase (CD73) in tumor contributes its evasion due the dysregulation extracellular adenosine (ADO), which significantly inhibits function antitumor T cells increases activity immunosuppressive cells. Herein, we drastically inhibit...
Abstract The J‐aggregation of dye‐functional group conjugates, which results in intriguing photophysical properties and highly ordered structures, has several advantages over that monomeric dyes exhibits augmented performance compared to functional groups, thereby providing a novel platform for devising materials with advanced functions. Herein, it is reported molecularly engineered nanodisc by the antiparallel halogenated BODIPY‐Gd(III), conjugate. directional halogen‐bonding interactions...
Selective ablation of tumor cells allows safe eradication, thereby minimizing off‐target damage, while specifically inducing immunogenic cell death (ICD) rather than commonly non‐immunogenic apoptosis enables activation anti‐tumor immune response against residual cancer cells, including metastatic lesions. Herein, we present a general strategy leveraging novel photothermal agent (PTA) that concomitantly precise killing and immunity. The unique PTA scaffold exhibits unexpected inherent...
Selective ablation of tumor cells allows safe eradication, thereby minimizing off‐target damage, while specifically inducing immunogenic cell death (ICD) rather than commonly non‐immunogenic apoptosis enables activation anti‐tumor immune response against residual cancer cells, including metastatic lesions. Herein, we present a general strategy leveraging novel photothermal agent (PTA) that concomitantly precise killing and immunity. The unique PTA scaffold exhibits unexpected inherent...
Abstract Developing electron‐deficient (hetero)arenes with optimized geometries and electronic properties is imperative for advancing n ‐type polymers organic devices. We report here the design synthesis of two chlorinated imide‐functionalized heteroarenes, namely chlorine‐substituted bithiophene imide (ClBTI) its fused dimer (ClBTI2). The corresponding show a near‐planar framework, appropriate frontier molecular orbital levels, good solubility. When integrated into thin‐film transistors,...
Abstract Well‐defined cyclic ‐polymers ( ‐PAzoMMAs), bearing side‐chain phenylazo naphthalene chromophore, were successfully synthesized by the combination of atom transfer radical polymerization (ATRP) and copper(I)‐catalyzed azide/alkyne cycloaddition “click” reaction, as verified GPC, 1 H NMR, FTIR, MALDI‐TOF mass spectrometry. The ‐PAzoMMA showed higher glass transition temperatures than linear with same molecular weight. Interestingly, exhibited deeper modulation depth (M.D.) induced...
近年来, 由于聚合物点(PDs)具有良好的荧光性质和光收集能力, 受到了人们广泛的关注, 应用在生物成像和检测等领域. 然而, 目前报道的聚合物点大多数是指共轭聚合物经过组装、固定形成的, 因此聚合物点保持着形成之前的共轭聚合物的相关性质, 且具有更好的稳定性和进一步功能化的能力. 本文中我们研究的聚合物点是指从非共轭线性聚合物为原料而制备的聚合物点, 这类聚合物包括聚环氧乙烯, 多糖等. 聚合物点不仅包含使其具有荧光的碳化中心, 还具有外围的聚合物链结构. 因此, 可以拓展应用聚合物点的聚合物特性. 我们利用PDs的荧光中心和外围的聚合物链双功能性质, 详细研究了基于PDs制备功能性纳米复合材料体系. 首先, 我们原位制备了聚乙烯醇/PDs纳米复合膜材料(PDs是直接通过聚乙烯醇可控碳化而产生的). 复合材料不仅保持了PDs的荧光特性, 还保持了聚乙烯醇易加工的特性, 如可以制备成纳米复合膜材料, PDs含量可以根据需要调控: 0, 20%, 40%, 60%, 80%, 100%. 纳米复合膜材料在不同激发光下具有多颜色发光性质. 进一步的,...
Abstract Utilizing the J‐stacking of dyes to drive assembly amphiphilic polymers can not only construct supramolecular assemblies with novel architectures but also provide a stabilizing solution for dye J‐aggregation promote its biomedical applications. However, tightly entangled hydrophobic segments disrupt orderly arrangement molecules, thereby preventing stacking‐driven block copolymers. Herein, “molecular glue” strategy is reported that uses small molecule as molecular glue restore...
The development of photodynamic nanomedicines that can alleviate intratumoral oxygen deficiency during therapy (PDT) is great significance for improving the therapeutic outcome solid tumors characterized by severe hypoxia. Massive consumption due to vigorous cellular respiration, i.e., mitochondrial-associated oxidative phosphorylation (OXPHOS), another major cause tumor hypoxia in addition insufficient supply. Moreover, depletion PDT further exacerbates shortage oxygen. In this work, we...
Photoactivatable metallodrugs combining tumor cell eradication and immune stimulation hold immense promise for targeted cancer therapy. However, limitations such as oxygen dependence, narrow visible light responsiveness, poor immunogenicity hinder their efficacy in deep solid tumors with hypoxic immunosuppressive microenvironments. Herein, we present a novel design strategy transition metal(II)-coordinated ligand radicals exhibiting intense near-infrared-II (NIR-II) absorption, unique...