A5029534021- Autophagy in Disease and Therapy
- Genomics, phytochemicals, and oxidative stress
- Polysaccharides and Plant Cell Walls
- Genetics, Aging, and Longevity in Model Organisms
- Seaweed-derived Bioactive Compounds
- Flavonoids in Medical Research
- Advanced Glycation End Products research
- Nanoparticle-Based Drug Delivery
- Robotics and Sensor-Based Localization
- Graphene and Nanomaterials Applications
- Nanoplatforms for cancer theranostics
- Human Pose and Action Recognition
- Phytochemicals and Antioxidant Activities
- Natural product bioactivities and synthesis
- Medicinal Plants and Bioactive Compounds
- Gut microbiota and health
- Microbial Metabolites in Food Biotechnology
- Cancer Mechanisms and Therapy
- Probiotics and Fermented Foods
- Histone Deacetylase Inhibitors Research
- Microbial Metabolic Engineering and Bioproduction
- Sphingolipid Metabolism and Signaling
- Advances in Cucurbitaceae Research
- Bioactive natural compounds
- Pregnancy-related medical research
Zhejiang Gongshang University
2022-2025
Guangxi University
2024
Zhejiang University
2018-2022
National University of Singapore
2022
China United Network Communications Group (China)
2021
ZheJiang Institute For Food and Drug Control
2019-2021
Institute of Food Science
2021
Ministry of Agriculture and Rural Affairs
2019-2020
Hitachi (Japan)
2018
Hitachi High-Tech (Japan)
2018
Abstract The human gastrointestinal (GI) tract microbiome secretes various metabolites that play pivotal roles in maintaining host physiological balance and influencing disease progression. Among these metabolites, bacteriocins—small, heat‐stable peptides synthesized by ribosomes—are notably prevalent the GI region. Their multifaceted benefits have garnered significant interest scientific community. This review comprehensively explores methods for mining bacteriocins (traditional separation...
Lung cancer has been threatening human health worldwide for a long time. However, the clinic therapies remain unsatisfactory. In this study, anti-adenocarcinoma lung A549 cell line abilities of Tetrastigma hemsleyanum tuber flavonoids (THTF) were evaluated in vivo, and isobaric tags relative absolute quantification (iTRAQ)-based proteomic analysis was conducted to detect protein alterations THTF-treated solid tumors. The differentially expressed proteins related cytoskeleton mostly...
The main flavonoid components of Radix Tetrastigma (RTF) were extracted and identified by UPLC-TOF/MS. In vitro, RTF prevented inflammation in RAW 264.7 cells suppressing morphological (both cell nucleus) changes, decreasing nitric oxide (NO), inducible synthase (iNOS), cyclooxygenase-2 (COX-2) contents. Exposure to LPS also leads oxidant damage, alleviated damage mitochondria, decreased O2− accumulation, restored the glutathione level. intervention expression c-Jun N-terminal kinase (JNK)...
A mouse, a cancer-combating winner, is giving his speech about experience in conquering cancer. He excitedly introduces that <italic>TVF</italic>, flavones derived from <italic>Tetrastigma hemsleyanum</italic> vine, effectively achieved tumor ablation.
Type 2 diabetes mellitus is a disease associated with an oxidative milieu that often leads to adverse health outcomes. Multiple anthocyanins have been reported possess outstanding antioxidant activity, however, their effects on hyperglycemia-related stress remain elusive. In the present study, cyanidin-3-O-glucoside (C3G), typical anthocyanin various widely accepted benefits, was applied alleviate in pancreas islets under conditions of hyperglycemia. Firstly, significantly decreased...
Abstract Food‐borne polyphenols have long contributed to human health via multifaceted mechanisms, while emerged studies especially those published in recent 10 years witnessed the close relevance between bioactivity of with iron homeostasis. Polyphenols are involved various physiological processes and manifest multidirectional regulative effects. The diversiform polyphenols–iron interactions extended cognition disorders diseases. This review aims present a comprehensive scope interactions,...
Nisin, derived from Streptococcus lactis, is the only approved bacteriocin for food preservation. With wide application in multitudinous food, progressively increasing studies have focused on its anti-inflammatory activity, while structure-effect relationship and molecular mechanism remain unclear. In this study, efficiency structural differences of two typical types nisin, A Z, were first compared based a mouse model. The self-assembly behavior nisin was uncovered, characteristics...
Apios americana Medikus was once widely accepted as staple food in India for a long time, and the tuber of which possesses high nutrients. During past decades, most research has focused on biological activity tubers whereas leaves were ignored. In this study, leaf extract (ALE) obtained seven compounds identified. LPS-induced RAW264.7 cells used to study anti-inflammation ALE. As expected, ALE reduced secretion nitric oxide (NO) inflammatory cytokines via inhibition NF-κB MAPK signaling...
The main flavonoid components of Radix Tetrastigma (RTF) were extracted and characterized by high performance liquid chromatography. In vitro, RTF suppressed the viability A549 cells, inhibited invasion migration damaging lamellipodium structure F-actin. vivo, compared to model group, growth tumor volumes in nude mice, decreased weight tumor. To uncover inner mechanism, proliferation-related proteins: PCNA, Ki67 apoptosis-related caspase-3, caspase-9, Bax Bcl-2 examined immunohistochemical...
Lung cancer with high mortality is regarded as a challenging global problem unsatisfied curative effects. Clinically, the chemotherapy drugs are often faced side-effects and tumor resistance. Radix Tetrastigma (RT) traditional Chinese herb now kind of functional food. In this study, A549-bearing nude mice control was adopted to evaluate anti-tumor capacity RT. Results demonstrated that RT showed excellent ability no side-effect on compared drug (5-Fu).Further studies proved down-regulated...
Cancer is a major threat to human health worldwide, yet the clinical therapies remain unsatisfactory. In this study, we found that Tetrastigma hemsleyanum leaves flavone (TLF) intervention could achieve tumor inhibition. Besides, neochlorogenic acid (NA), which had highest absorbance peak in HPLC profile of TLF, showed superior anti-proliferation ability over and effectively trigger apoptosis, restrain migration, facilitate cytoskeleton collapse, suggesting its key role TLF's anticancer...
Glutamic acid (Glu) is a worldwide flavor enhancer with various positive effects. However, Glu-induced neurotoxicity has been reported less. Tetrastigma hemsleyanum (TH), rare herbal plant in China, possesses high medicinal value. More studies paid attention to tuber of TH whereas vine part (THV) attracts fewer focus. In this study, we extracted and purified flavones from THV (THVF), UPLC-TOF/MS showed THVF was consisted 3-caffeoylquinic acid, 5-caffeoylquinic quercetin-3-O-rutinoside,...