A5104200340- Water Quality Monitoring and Analysis
- Cancer-related molecular mechanisms research
- Plant Stress Responses and Tolerance
- Probiotics and Fermented Foods
- Lipid metabolism and biosynthesis
- Advanced Photocatalysis Techniques
- Food composition and properties
- Neuroinflammation and Neurodegeneration Mechanisms
- Nitrogen and Sulfur Effects on Brassica
- Gut microbiota and health
- Plant Molecular Biology Research
- CO2 Reduction Techniques and Catalysts
- Photosynthetic Processes and Mechanisms
- Prostate Cancer Treatment and Research
- Advanced Glycation End Products research
- Metabolomics and Mass Spectrometry Studies
- Wastewater Treatment and Nitrogen Removal
- Mechanisms of cancer metastasis
- Plant responses to elevated CO2
- Microbial Metabolites in Food Biotechnology
- Ferroptosis and cancer prognosis
- Phytoestrogen effects and research
- Immune cells in cancer
- Plant biochemistry and biosynthesis
- Constructed Wetlands for Wastewater Treatment
Nanjing Drum Tower Hospital
2024-2025
Jiyang College of Zhejiang A&F University
2023-2025
Florida International University
2022-2025
Nanjing University of Chinese Medicine
2024-2025
First Affiliated Hospital of Jinan University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
Central South University
2024
Zhejiang Provincial People's Hospital
2024
Guangdong Academy of Sciences
2023-2024
Ocean University of China
2023-2024
A component of licorice polysaccharide (GPS-1) was extracted from licorice, its primary structure identified and characterized for the first time, immunomodulatory activity studied. Crude isolated purified by DEAE sepharose FF ion-exchange column chromatography Chromdex 200 PG gel filtration to obtain a Glycyrrhiza named GPS-1. NMR methylation analysis revealed that GPS-1 is composed homogalacturonan (HG)-type pectin with 4)-D-GalpA-(1 as backbone. This study also examined significant role...
Abstract The human gastrointestinal (GI) tract microbiome secretes various metabolites that play pivotal roles in maintaining host physiological balance and influencing disease progression. Among these metabolites, bacteriocins—small, heat‐stable peptides synthesized by ribosomes—are notably prevalent the GI region. Their multifaceted benefits have garnered significant interest scientific community. This review comprehensively explores methods for mining bacteriocins (traditional separation...
Thionins are important antibacterial peptides in plants. However, the roles of plant thionins, especially defensin-dissimilar alleviating heavy-metal toxicity and accumulation remain unclear. Here, cadmium (Cd)-related functions mechanisms rice thionin OsThi9 were investigated. was significantly upregulated response to Cd exposure. localized cell wall shown bind Cd; these characters help increase tolerance. In Cd-exposed plants, overexpression increased binding, decreasing upward...
Rhododendron simsii (R. simsii), a significant ornamental plant species, is adversely affected by the severe soil heavy metal pollution resulting from rapid industrialization, particularly in terms of its growth environment. Cadmium (Cd), representative pollutant, poses threat to and photosynthetic physiology. Despite importance understanding Cd stress resistance rhododendrons, research this area limited. This study focused on role exogenous melatonin (MT) mitigating Cd-induced stress,...
In this study, multiple-impurity adsorption purification (MIA) technologies and liquid chromatography–tandem mass spectrometry (LC-MS/MS) were used to establish a method for detecting 11 mycotoxins in maize. The conditions MIA optimized. Maize was extracted with 70% acetonitrile solution, enriched, purified using technologies, then, analyzed via LC-MS/MS. results showed that the linear correlation coefficients of >0.99, sample recoveries ranged from 77.5% 98.4%, relative standard...
Significance Statement Hypoxia is a hallmark of renal ischemia-reperfusion injury (IRI) and serves as an essential regulator innate immune responses during this process, although the mechanisms regulation remain unclear. Here, we showed in murine model that HIF-2 α knockout dendritic cells (DCs) exacerbated IRI through activation natural killer T cells. Mechanistically, deficiency upregulated CD36 expression DCs, leading to cellular lipid accumulation. Pharmacologic inhibition DCs resulted...
This study presents a ligand-engineering strategy to modulate the reconstruction behavior of Cu-based complexes, resulting in situ formation stable Cu 0 /Cu + species and thereby enhancing their electrochemical CO 2 reduction performance.
Helicobacter pylori is a gastric pathogen that colonizes approximately 50% of the world's population. Infection with H. causes chronic inflammation and significantly increases risk developing duodenal ulcer disease cancer. In present study, we found phenyl lactic acid (PLA) derived from Lactobacillus plantarum ZJ316 (L. ZJ316) can directly inhibit growth urease activity in vitro minimum inhibitory concentration (MIC) 2.5 mg mL-1. Moreover, PLA also caused dramatic morphological...
The thermal treatment carried out in the processing of apple products is very likely to induce Maillard reaction produce furfurals, which have raised toxicological concerns. This study aimed elucidate formation furfural compounds treated with pasteurization and high pressure (HPP). method for simultaneous determination five including 5-hydroxymethyl-2-furfural (5-HMF), (F), 4-hydroxy-2,5-dimethyl-3(2H)-furanone (HDMF), 2-acetylfuran (FMC), 5-Methyl-2-furfural (MF) using performance liquid...
Abstract Chemotherapy is the cornerstone of triple‐negative breast cancer. The poor effectiveness and severe neuropathic pain caused by it have a significant impact on immune system. Studies confirmed that cells in tumor microenvironment (TME), critical roles regulation prognosis. In this study, revealed painless administration Esketamine, combined with Cisplatin (DDP), can exert an anti‐tumor effect, which further boosted hydrogel delivery It also discovered Esketamine DDP co‐loaded...
Moderate altitude exposure has shown beneficial effects on diabetes incidence but the underlying mechanisms are not understood. Our study aimed to investigate how human gut microbiome impacted serum metabolome and associated with glucose homeostasis in healthy Chinese individuals upon moderate-altitude exposure. Faecal composition was assessed using shotgun metagenomic sequencing. Serum acquired by untargeted metabolomics technology, amino acids (AAs) propionic acid were quantified targeted...
Objectives: Age-related speech perception difficulties may be related to a decline in central auditory processing abilities, particularly noisy or challenging environments. However, how the activation patterns stimulation different noise situations change with normal aging has yet elucidated. In this study, we aimed investigate effects of environments and on cortical activation. Design: We analyzed functional near-infrared spectroscopy signals 20 young adults, 21 middle-aged elderly...
Abstract This study investigates the effectiveness of an exopolysaccharide (EPS)‐producing strain ( Lactiplantibacillus plantarum L75) alone or in combination with Saccharomyces cerevisiae on fermentation characteristics, antioxidant capacities and microbial community successions oat silage stored at various temperatures. A rapid decrease pH lactic acid accumulation was observed silages treated L. S. (LS) as early 3 days ensiling p < 0.05). Over period 7–60 days, (L)‐inoculated groups...
Abstract Aims Excessive neuroinflammation mediated mainly by microglia plays a crucial role in ischemic stroke. AZD1390, an ataxia telangiectasia mutated (ATM) specific inhibitor, has been shown to promote radio‐sensitization and survival central nervous system malignancies, while the of AZD1390 stroke remains unknown. Methods Real‐time PCR, western blot, immunofluorescence staining, flow cytometry enzyme‐linked immunosorbent assays were used assess activation release inflammatory cytokines....
Prostate adenocarcinoma (PRAD) is a prevalent global malignancy which depends more on lipid metabolism for tumor progression compared to other cancer types. Although Stearoyl-coenzyme A desaturase (SCD) documented regulate in multiple cancers, landscape analysis of its implications PRAD are still missing at present. Here, we conducted an diverse datasets revealing elevated SCD expression the cohort both mRNA and protein levels. Interestingly, was associated with promoter hypermethylation...
Many groundwater and surface water bodies around the world show a puzzling often steady increase in nitrogen (N) concentrations, despite significant decline of agricultural N inputs. This study uses combination long-term hydrogeochemical hydraulic monitoring, molecular characterization dissolved organic matter (DOM), column experiment, reactive transport modeling to unravel processes controlling N-reactive mass budgets under impacts dynamic hydrologic conditions at field site central Yangtze...