A5066487458- Gastroesophageal reflux and treatments
- Esophageal and GI Pathology
- Eosinophilic Esophagitis
- Education, Psychology, and Social Research
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Pancreatitis Pathology and Treatment
- Dysphagia Assessment and Management
- Liver Disease and Transplantation
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Surgical Treatments
- Esophageal Cancer Research and Treatment
- Helicobacter pylori-related gastroenterology studies
- Pediatric Urology and Nephrology Studies
- Liver Disease Diagnosis and Treatment
- Gastrointestinal motility and disorders
- Gout, Hyperuricemia, Uric Acid
- Abdominal vascular conditions and treatments
- Renal function and acid-base balance
- Neuroendocrine Tumor Research Advances
- Congenital Diaphragmatic Hernia Studies
- Diet, Metabolism, and Disease
- Respiratory and Cough-Related Research
- Pelvic floor disorders treatments
- Multiple and Secondary Primary Cancers
Masaryk University
2008-2022
University Hospital Brno
2007-2022
Ocní klinika
2018
There have been only a few studies dealing with the incidence of chronic pancreatitis published. Over last 80 years, original describing were undertaken, including in Scandinavia, Switzerland, Hungary and Poland. Incidence varied geographically, from 1.6 new cases per year among 100,000 inhabitants Switzerland to 23 Finland. The aetiology 70% all was alcoholic pancreatitis. Czech Republic is 7.9 year, similar that Denmark Germany, but higher than Poland or Switzerland. In our study, main...
Abstract Bicarbonate and phosphate constitute major salivary buffering components, their importance consists in the neutralization of acidic gastric contents during reflux episodes. In this work, capillary electrophoresis with capacitively coupled contactless conductivity detector was applied for analysis bicarbonate, phosphate, another inorganic (chloride, nitrite, nitrate, sulfate, thiocyanate) organic anions (acetate, butyrate) to evaluate levels saliva. The background electrolytes...
Injection of botulinum toxin (BT) and pneumatic dilatation are available methods in nonsurgical treatment achalasia. Authors anticipate beneficial effect prior BT injection on the success duration its effect. There no long-term data to assess efficacy combined treatment. From 1998 2007, 51 consecutive patients (20 men 31 women, age 24-83) with achalasia were included prospectively followed up. Each patient received 200 IU into lower esophageal sphincter (LES) during endoscopy 8 days later...
Background & Aims: To compare the eficacy and tolerance of sodium picosulphate/magnesium citrate(PMC) polyethylene glycol (PEG) in a single or split dose regimen for colonoscopy bowel preparation.Methods: A prospective, randomized, endoscopist-blinded, multicenter study. The patients were randomly assigned to receive PMC (PMC4/0) PEG (PEG4/0) 4L day before 2+2L (PMC2/2) 3+1L (PEG3/1) one morning colonoscopy. Each patient was interviewed determine his/her subjective preparation procedure....
To evaluate the analytical parameters of a lateral flow (LF) pepsin immunoassay (Peptest) and assess its suitability in diagnostics gastroesophageal reflux disease (GERD).Peptest is noninvasive assay to analyze saliva, intended for use GERD diagnostics. Although commercialized, fundamental studies on performance are missing. The therefore requires basic parameter evaluation clinical practice.Assay reaction's time dependence, reader device repeatability, individual LF devices longitudinal...
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare autosomal recessive disease caused by mutation in the TYMP gene encoding thymidine phosphorylase. MNGIE causes gastrointestinal and neurological symptoms homozygous individuals often misdiagnosed as anorexia nervosa, inflammatory bowel disease, or celiac disease. We present case of 26-year-old female with MNGIE, who was initially diagnosed nervosa Crohn’s The diagnosis established biochemical confirmation elevated serum...
The adalimumab biosimilars FKB327 and GP2017 were approved for the therapy of patients with inflammatory bowel disease (IBD). Relatively few prospective studies biosimilar in IBD have been published. aim this observational study was to evaluate effectiveness safety adalimumab.Adalimumab (Hulio®) (Hyrimoz®) indicated 50 naive terms biological Crohn's (CD) or ulcerative colitis (UC). Effectiveness evaluated via Disease Activity Index [CDAI] Mayo Scoring System [MSS] CD UC, respectively, before...
BACKGROUNDPublic awareness of colorectal cancer (CRC) and uptake CRC screening remain challenges.The viewpoints the target population (asymptomatic individuals older than 50) regarding information sources reasons for against participation in are not well known Czech Republic.This study aimed to acquire independent opinions from independently on health system. AIMTo investigate source barriers facilitators screening. METHODSA survey among relatives (aged 50 older) university students was...
The aim of the study was to determine prevalence and detailed data concerning incidence spontaneous bacterial peritonitis in Czech Republic. Ninety-nine patients with liver cirrhosis ascites were examined. Spontaneous diagnosed 35 (35.4%). It revealed more often alcoholic aetiology whose anamnesis involved sub-febrile or febrile states deterioration ascites. Elevated serum leucocyte counts increased levels C-reactive protein can contribute diagnosis. A low level total albumin predisposes...
Objectives COVID-19 might either be entirely asymptomatic or manifest itself with a large variability of disease severity. It is beneficial to identify early patients high risk severe course. The aim the analysis was develop prognostic model for prediction course acute respiratory infection. Design A population-based study. Setting Czech Republic. Participants first 7455 consecutive who were identified by reverse transcription-PCR testing from 1 March 2020 17 May 2020. Primary outcome Severe...
Background . The aim of this study was to monitor oropharyngeal bacterial colonization in patients indicated for percutaneous endoscopic gastronomy (PEG). Methods Oropharyngeal swabs were obtained from prior PEG placement. A development peristomal infection evaluated. analysis and site pathogens done. Results Consecutive 274 referred due neurological disorder or cancer completed the study. with observed 69% (190/274), dominantly neurologic subgroup ( P < 0.001). Peristomal occurred 30...
Abstract In this work, capillary electrophoresis with contactless conductometric detection (CCD) was used for the analysis of ionic content exhaled breath condensate (EBC) to differentiate between healthy individuals and patients gastroesophageal reflux disease (GERD). The collected using a miniature sample collection device analyzed separation electrolyte composed 20 mM 2-(N-morpholino)ethanesulfonic acid, L-histidine, 2 18-Crown-6 30 M cetyltrimethylammonium bromide. anions took less than...
Gastroesophageal reflux disease and its typical symptoms heartburn regurgitation is one of the most common gastrointestinal disorders. Besides esophageal awareness extraesophageal increasing. The diagnosis usually based on history endoscopically visible injury in some patients. Normal endoscopic finding refractory standard treatment should evoke further examination. Proton pump inhibitors have been mainstay medical therapy. Long term maintenance may raise side effects therapeutic...
Úvod:Crohnova nemoc (Crohn's disease - CD) patří mezi chronické onemocnění, které značně ovlivňuje kvalitu života (quality of life QoL) u těchto pacientů. Cílem studie bylo stanovit, jaký vliv má chirurgická léčba na pacientů s CD a určit faktory, ovlivňují pooperační QoL. Metody pacienti:Porovnávána byla QoL před operací v pooperačním období pacientů, kteří podstoupili Chirurgické klinice střevní resekci z indikace letech 2010-2016. Pacienti vyplnili standardizovaný dotazník k měření...