A5007570009- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Liver Disease Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Metabolism, Diabetes, and Cancer
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal Tumor Research and Treatment
- Paraoxonase enzyme and polymorphisms
- Microbial Inactivation Methods
- Liver Disease and Transplantation
- Liver Diseases and Immunity
- Childhood Cancer Survivors' Quality of Life
- Retinoids in leukemia and cellular processes
- Drug-Induced Hepatotoxicity and Protection
- Eosinophilic Esophagitis
- Cancer Diagnosis and Treatment
- Bone health and treatments
- Gastric Cancer Management and Outcomes
- Digestive system and related health
- Iron Metabolism and Disorders
- Phagocytosis and Immune Regulation
- Abdominal vascular conditions and treatments
- Colorectal Cancer Screening and Detection
- Stress Responses and Cortisol
- Bone and Dental Protein Studies
Charles University
2009-2023
General University Hospital in Prague
2003-2023
Opća bolnica Karlovac
2010
Iscare I.V.F
1997-2006
Ocní klinika
1997
Oxidative stress has been implicated in the pathogenesis of chronic pancreatitis (CP) and pancreatic cancer (PC). The study aim was to assess oxidative markers antioxidant defense system patients with CP those PC.Activities superoxide dismutase 1 (SOD1), catalase (CAT), glutathione peroxidase (GPX1), reductase (GR), arylesterase (PON1-A) lactonase (PON1-L) activities paraoxonase (PON1) concentrations reduced glutathione, conjugated dienes low-density lipoprotein (CD/LDL) oxidized LDL...
Prognosis of patients with pancreas cancer is very poor. The aim the study was to test significance laboratory parameters in prognosis cancer. studied group included 57 (31 men, 26 women, mean age 65 ± 9 years). Blood collected at time diagnosis and basic parameters, including nutritional inflammatory markers tumour were measured. Patients followed up until death (median survival 147 days). Ferritin, iron, albumin, prealbumin, cholinesterase, haemoglobin, C-reactive protein, alkaline...
The aim of this study was to evaluate the safety irreversible electroporation (ire) and outcome patients undergoing ire locally advanced pancreatic cancer (Pc).twenty-one with unresectable Pc underwent open (n=19) or percutaneous (n=2) tumor using Nanoknife system two electrodes that were repositioned several times affect whole mass.The size 39±10mm a range from 21 65mm.Five neoadjuvant chemotherapy seven treated after ire.complications occurred in five patients, which resulted prolongation...
Pancreatic cancer (PC) ranks as the fourth cause of cancer-related deaths in Czech Republic. Evidence exists that deregulation fatty acid (FA) metabolism is connected with some malignancies; therefore, we decided to analyze FA profile plasma lipid classes patients PC relation tumor staging, nutritional status, and survival. The study included 84 (47 males, 37 females) 68 controls (36 32 females). patterns were analyzed by gas-chromatography. We observed increased proportion total...
We analyzed concentrations of osteopontin (OPN) in patients with pancreatic ductal adenocarcinoma (PDAC) order to determine firstly whether it is useful distinguish between PDAC and those chronic non-hereditary pancreatitis (CP) type 2 diabetes mellitus (T2DM), secondly OPN depend on the stage.Groups consisting 64 PDAC, 71 CP, 67 T2DM 48 healthy controls (CON) were enrolled study. Controls compared regard levels OPN, oxidative stress markers, conventional tumor markers other biochemical...
The aim of this study was to analyze the relationship serum leptin as well adiponectin and manifestation pancreatic cancer (PC). Serum leptin, adiponectin, glucose homeostasis insulin resistance (expressed HOMA-IR) were investigated in 64 patients with newly diagnosed PC compared healthy controls (CON group) 75 type 2 diabetes (DM2). Seventy percent had DM2. levels lower, whilst adiponectin/leptin ratio higher (both without DM2), comparison CON DM2 groups (P < 0.001) independently age, BMI...
Human paraoxonase 1 (PON1) has been shown to decrease the level of systemic oxidative stress, which is thought contribute cancer development. The aim this study was examine interrelationships between PON1 status and some clinical characteristics in patients with pancreatic (PC). A group 73 consecutive PC (stage II–IV) control subjects were examined. Laboratory studies included five polymorphisms gene (L55M, Q192R, -108C/T, -126C/T, -162A/G), arylesterase (PON1-A) lactonase (PON1-L)...
Pancreatic cancer (PC) is one of the most frequent gastrointestinal malignancies with extremely poor prognosis. In spite a relative low incidence PC, in comparison other cancers, PC fourth leading cause death USA both sexes. The available data clearly suggest that diabetes mellitus (DM) can be long-standing and an early manifestation disease. Besides DM, insulin resistance high levels are linked as well increased risk, including PC. variable number tandem repeats (VNTR) locus upstream gene...
To identify non-invasive biomarkers of non-metastatic pancreatic cancer (PC), the blood from 186 patients (PC n=28; DM-diabetes mellitus n=60; ChP-chronic pancreatitis n=47; healthy controls n=51) was analyzed for 58 candidate biomarkers. Their effectiveness to PC compared with CA19-9. Panel defined by Random-forest (RF) analysis (CA19-9, AAT, IGFBP2, albumin, ALP, Reg3A, HSP27) outperforms CA19-9 in discrimination DM (AUC 0.92 vs. 0.82). (S100A11, CA72-4, CA19-9, CB, MMP-7, S100P-s, Reg3A)...
The aim of the study was to determine prevalence and detailed data concerning incidence spontaneous bacterial peritonitis in Czech Republic. Ninety-nine patients with liver cirrhosis ascites were examined. Spontaneous diagnosed 35 (35.4%). It revealed more often alcoholic aetiology whose anamnesis involved sub-febrile or febrile states deterioration ascites. Elevated serum leucocyte counts increased levels C-reactive protein can contribute diagnosis. A low level total albumin predisposes...
Objective To evaluate the efficacy and learning curve of endoscopic ultrasound‐guided fine needle aspiration biopsy ( EUS ‐ FNAB ) diagnostics pancreatic lesions over 8 years (2007–2014). Material methods using a Linear Echoendoscope Olympus was performed in 531 patients, mostly without rapid on‐site evaluation ROSE ). Smears plus cytoblock sections were used routinely. Immunocytochemistry utilised as indicated. Results The average, satisfactory sampling rate increased from 61.2% first...
The development of dendritic arborization was analysed and quantitative data (number stem dendrites, their segments total length tree) were obtained. Early administration cortisol (on day 11) inhibited all three parameters small stellate neurones situated in the corticoid zone telencephalon 19-day-old chick embryos, but large number only impaired. Late this hormone 17) did not influence network neurones, it affected neurones. These results suggest that dendrites is set first, followed by...