A5043784494- Paraoxonase enzyme and polymorphisms
- Urban Transport and Accessibility
- Fatty Acid Research and Health
- Pancreatitis Pathology and Treatment
- Vitamin C and Antioxidants Research
- Biochemical Acid Research Studies
- Childhood Cancer Survivors' Quality of Life
- Advanced Glycation End Products research
- Electrolyte and hormonal disorders
- Education, Psychology, and Social Research
- Clinical Nutrition and Gastroenterology
- Sepsis Diagnosis and Treatment
- Renal function and acid-base balance
- Cancer, Lipids, and Metabolism
- Ureteral procedures and complications
- Medical and Biological Ozone Research
- Transportation and Mobility Innovations
- Glutathione Transferases and Polymorphisms
- Cancer Treatment and Pharmacology
- Chemotherapy-induced cardiotoxicity and mitigation
- Hormonal Regulation and Hypertension
- Regulation of Appetite and Obesity
- Innovative Approaches in Technology and Social Development
- Sustainability and Climate Change Governance
- GDF15 and Related Biomarkers
Jan Evangelista Purkyně University in Ústí nad Labem
2023-2025
Charles University
2007-2024
Czech Academy of Sciences
2019
Czech Academy of Sciences, Institute of Physiology
2019
General University Hospital in Prague
2014-2015
Oxidative stress has been implicated in the pathogenesis of chronic pancreatitis (CP) and pancreatic cancer (PC). The study aim was to assess oxidative markers antioxidant defense system patients with CP those PC.Activities superoxide dismutase 1 (SOD1), catalase (CAT), glutathione peroxidase (GPX1), reductase (GR), arylesterase (PON1-A) lactonase (PON1-L) activities paraoxonase (PON1) concentrations reduced glutathione, conjugated dienes low-density lipoprotein (CD/LDL) oxidized LDL...
<b><i>Objective: </i></b>In the pathogenesis of metabolic syndrome (MetS), an increase oxidative stress could play important role which is closely linked with insulin resistance, endothelial dysfunction, and chronic inflammation. The aim our study was to assess several parameters antioxidant status in MetS. <b><i>Methods: </i></b>40 subjects MetS 40 age- sex-matched volunteers without were examined for activities superoxide dismutase (CuZnSOD),...
We analyzed concentrations of osteopontin (OPN) in patients with pancreatic ductal adenocarcinoma (PDAC) order to determine firstly whether it is useful distinguish between PDAC and those chronic non-hereditary pancreatitis (CP) type 2 diabetes mellitus (T2DM), secondly OPN depend on the stage.Groups consisting 64 PDAC, 71 CP, 67 T2DM 48 healthy controls (CON) were enrolled study. Controls compared regard levels OPN, oxidative stress markers, conventional tumor markers other biochemical...
Abstract This study analyzes fatty acid (FA) composition in plasma lipids and erythrocyte phospholipids while comparing septic non‐septic critically ill patients. The aim was to describe impacts of infection the inflammatory process. Patients with severe sepsis (SP, n = 13); age‐, sex‐ APACHE II score‐matched systemic response syndrome (NSP, age‐/sex‐matched healthy controls (HC, 13) were included a prospective case–control during first 24 h after admission intensive care unit. In both SP...
Metabolic syndrome (MS) is defined by the clustering of several components (MSC), which include abdominal fat accumulation, impaired glucose homeostasis, hypertriglyceridemia, lowered high-density lipoprotein cholesterol, increased blood pressure, and hyperuricemia. also accompanied oxidative stress inflammation as well altered composition esterified fatty acids (FA). Therefore, we have investigated 210 men (categorized into six groups with increasing number MSC) to find trends in extent...
(1) Objectives: Intestinal failure in home parenteral nutrition patients (HPNPs) results oxidative stress and liver damage. This study investigated how a high dose of fish oil (FO) added to various lipid emulsions influences antioxidant status function markers HPNPs. (2) Methods: Twelve HPNPs receiving Smoflipid for at least 3 months were given FO (Omegaven) further 4 weeks. Then, the randomized subsequently receive Lipoplus ClinOleic 6 weeks or vice versa plus Omegaven after each cycle...
Human paraoxonase 1 (PON1) has been shown to decrease the level of systemic oxidative stress, which is thought contribute cancer development. The aim this study was examine interrelationships between PON1 status and some clinical characteristics in patients with pancreatic (PC). A group 73 consecutive PC (stage II–IV) control subjects were examined. Laboratory studies included five polymorphisms gene (L55M, Q192R, -108C/T, -126C/T, -162A/G), arylesterase (PON1-A) lactonase (PON1-L)...
Aim of the study is to define diagnostic accuracy selected urinary protein biomarkers in non-invasive detection primary and recurrent urothelial carcinoma bladder.The levels calprotectin, CD147, APOA4 deglycase DJ-1 were examined 255 individuals, including 60 controls with non-malignant urological disease, 61 patients a history bladder cancer negative cytology cystoscopy 134 cancer.Urinary concentrations determined by Enzyme-Linked Immunosorbent Assay (ELISA).During follow-up non-muscle...
Stroke is despite of progressive improvements in treatment and reperfusion strategies one the most devastating human pathology. However, as quality acute health care improves more people survive ischemic attack, healthcare specialists have to solve new challenges preserve reasonable life these patients. Thus, novel approaches which prevents comorbidities stroke improve survivors general has be developed experimentally tested. The aim present paper was establish reliable rat model middle...
Since the beginning of coronavirus pandemic in 2020, transport sector has faced new challenges connected with decreasing use public and passengers' concerns about possible contagion. Using focus groups data collection by telephone interviews during different phases pandemic, we investigated current what measures would help alleviate their fear using it again. Our findings show that amplified sensitivity to phenomena they perceived negatively already before such as overcrowded vehicles,...
To evaluate the diagnostic accuracy and prognostic performance of urinary plasma levels placental growth factor (PLGF) provide their comparison with results vascular endothelial A (VEGF-A) in patients primary recurrent bladder cancer.The enzyme-linked immunosorbent assay (ELISA) was used to assess concentrations PLGF VEGF-A 240 individuals.PLGF urine were significantly higher cancer than healthy individuals (p=0.003, p=0.005, respectively). Area under curve (AUC) 0.68; AUC 0.65. Patients...
Over the last few decades, urban transport planning framework has changed significantly towards sustainable mobility planning. It brings new requirements for education of experts. In paper, we discuss future academic concerning these changes based on case studies two prestigious technical faculties in Germany and Poland a social science faculty Czechia offering study programmes related to We applied self-assessment questionnaire investigate how prepare managers present concept students. Our...