A5089766990- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Extracellular vesicles in disease
- Neurogenesis and neuroplasticity mechanisms
- MicroRNA in disease regulation
- Reproductive Health and Technologies
- Neuroscience and Neuropharmacology Research
- Pluripotent Stem Cells Research
- Fibroblast Growth Factor Research
- Circular RNAs in diseases
- Carcinogens and Genotoxicity Assessment
- Neuroinflammation and Neurodegeneration Mechanisms
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Intraocular Surgery and Lenses
- Corneal Surgery and Treatments
- TGF-β signaling in diseases
- Histone Deacetylase Inhibitors Research
- Obesity, Physical Activity, Diet
- Retinal Diseases and Treatments
- Medicinal Plants and Neuroprotection
- Neuroscience and Neural Engineering
- Protein Degradation and Inhibitors
- Alzheimer's disease research and treatments
- Global Public Health Policies and Epidemiology
- Bone health and treatments
Texas A&M Health Science Center
2015-2025
Manipal Academy of Higher Education
2013-2025
Kasturba Medical College, Manipal
2012-2025
Texas A&M University
2019-2025
Universidade Federal de Alagoas
2019
Instituto do Cérebro
2019
Pontifícia Universidade Católica do Rio Grande do Sul
2019
Olin E. Teague Veterans Medical Center
2015-2018
Central Texas Veterans Health Care System
2015-2018
Yenepoya University
2017-2018
Status epilepticus (SE), a medical emergency that is typically terminated through antiepileptic drug treatment, leads to hippocampus dysfunction typified by neurodegeneration, inflammation, altered neurogenesis, as well cognitive and memory deficits. Here, we examined the effects of intranasal (IN) administration extracellular vesicles (EVs) secreted from human bone marrow-derived mesenchymal stem cells (MSCs) on SE-induced adverse changes. The EVs used in this study are referred A1-exosomes...
Significance This study provides evidence that human induced pluripotent stem cell (hiPSC)-derived medial ganglionic eminence (MGE) grafting into the hippocampus after status epilepticus can greatly reduce frequency of spontaneous seizures in chronic phase through both antiepileptogenic and antiepileptic effects. The changes comprised reductions host interneuron loss, abnormal neurogenesis, aberrant mossy fiber sprouting, whereas effects were evident from an increased occurrence silencing...
Memory and mood dysfunction are the key symptoms of Gulf war illness (GWI), a lingering multi-symptom ailment afflicting >200,000 veterans who served in Persian War-1. Research probing source disease has demonstrated that concomitant exposures to anti-nerve gas agent pyridostigmine bromide (PB), pesticides, war-related stress among chief causes GWI. Indeed, GWI-related chemicals (GWIR-Cs) mild animal models cause memory impairments alongside reduced neurogenesis chronic low-level...
Diabetic retinopathy (DR) is associated with retinal neovascularization, hard exudates, inflammation, oxidative stress and cell death, leading to vision loss.Anti-vascular endothelial growth factor (Anti-VEGF) therapy through repeated intravitreal injections an established treatment for reducing VEGF levels in the retina inhibiting neovascularization leakage of exudates prevent loss.Although anti-VEGF has several clinical benefits, its monthly injection potentially causes devastating ocular...
Epilepsy affects ∼60 million people worldwide. Most antiseizure medications in the market act on voltage-gated sodium or calcium channels, indirectly modulating neurotransmitter GABA glutamate levels multiple targets. Earlier studies made significant efforts to directly deliver into brain with varied success. Herein, we have hypothesized exogenous epilepsy through extracellular vesicles (EVs) from human GABA-producing cells and their progenitors as EVs largely mimic parent cell composition.
Diabetic retinopathy (DR) stands as a prevalent complication in the eye resulting from diabetes mellitus, predominantly associated with high blood sugar levels and hypertension individuals age. DR is severe microvascular of both type I II mellitus leading cause vision impairment. The critical approach to combatting halting advancement lies effectively managing glucose pressure diabetic patients; however, this seldom achieved. Both human animal studies have revealed intricate nature condition...
Abstract The recently published “Minimal information for studies of extracellular vesicles - 2023 (MISEV2023)” in the Journal Extracellular Vesicles has provided practical solutions to numerous challenges (EVs) researchers face. These guidelines are imperative novice and experienced promote unity within EV community. It is strongly recommended that laboratories working with EVs make MISEV2023 an essential handbook actively these during laboratory meetings, journal clubs, seminars, workshops,...
Double C-2 Like Domain Beta (DOC2B) located at 17q13.3 prevents metastasis by senescence induction and epithelial to mesenchymal transition inhibition in cervical cancer (CC). The extracellular vesicle (EV) mediated trafficking of DOC2B its impact on tumor suppressive activity are not investigated CC. Using a retroviral method, we first ectopically expressed SiHa, which do normally express DOC2B. DOC2B-SiHa vector-SiHa EVs were co-incubated separately with recipient cell subjected various...
Enduring brain dysfunction is amid the highly manifested symptoms in veterans with Gulf War Illness (GWI). Animal studies have established that lasting GWI concomitant augmented oxidative stress, inflammation, and declined neurogenesis brain, systemic inflammation. We hypothesize drugs capable of restoring redox homeostasis will improve cognitive mood function modulation neuroinflammation neurogenesis. examined efficacy monosodium luminol-GVT (MSL), a drug promotes homeostasis, for improving...
The therapeutic effectiveness of the most widely used anticancer drug 5-fluorouracil (5-FU) is constrained by its high metabolism, short half-life, and rapid resistance after chemotherapy. Although various nanodrug delivery systems have been reported for skin cancer therapy, their retention, penetration targeting are still a matter concern. Hence, in current study, topical gel formulation that contains metal-organic framework (zeolitic imidazole framework; ZIF-8) loaded with 5-FU surface...
Male reproductive function has recently attracted increasing attention due to reports on time-related decline in semen quality. Furthermore, regional differences the quality have also been reported.To investigate among large cohort of infertile individuals at a level, terms sperm concentration, total motility, morphology and incidence azoospermia over period 13 years.University infertility clinic Kasturba Hospital, Manipal which is tertiary healthcare centre serving general...
The mitogen-activated protein kinases (MAPKs; also known as ERKs) are key intracellular signaling molecules that ubiquitously expressed in tissues and were assumed to be functionally equivalent. Here, we use the mouse lens a model system investigate whether MAPK1 plays specific role during development. MAPK3 is dispensable for We demonstrate that, although uniformly epithelium, its deletion significantly reduces cell proliferation peripheral region, an area referred germinative zone which...
Fibroblast growth factors (FGFs) play important roles in many aspects of embryonic development. During eye development, the lens and corneal epithelium are derived from same surface ectodermal tissue. FGF receptor (FGFR)-signaling is essential for cell differentiation survival, but its role development has not been fully investigated. In this study, we examined defects Fgfr2 conditional knockout mice which Cre expression activated at induction stage by Pax6 P0 promoter. The cornea LeCre,...
The magnitude of type 2 diabetes mellitus (T2DM) is ever-increasing in India, and at present, ~77 million people live with diabetes. Studies have established that T2DM increases the risk neurodegenerative disorders. This study aimed to determine age-related prevalence mild cognitive impairment (MCI) patients Indian population identify link between dysfunction serum lipid composition through untargeted targeted lipidomic studies. Using a cross-sectional study, we evaluated 1278 Montreal...