A5030640654- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Asthma and respiratory diseases
- Hypothalamic control of reproductive hormones
- Retinal Imaging and Analysis
- Ovarian function and disorders
- Retinal Diseases and Treatments
- Respiratory and Cough-Related Research
- Immunotherapy and Immune Responses
- Epilepsy research and treatment
- Glaucoma and retinal disorders
- Hormonal and reproductive studies
- Eosinophilic Esophagitis
- Sexual Differentiation and Disorders
- Growth Hormone and Insulin-like Growth Factors
- Sepsis Diagnosis and Treatment
- Viral Infections and Immunology Research
- Retinal and Optic Conditions
- Systemic Sclerosis and Related Diseases
- Long-Term Effects of COVID-19
- Neurological diseases and metabolism
- Hemodynamic Monitoring and Therapy
- Dermatological and Skeletal Disorders
- IL-33, ST2, and ILC Pathways
- Immunodeficiency and Autoimmune Disorders
Great Ormond Street Hospital for Children NHS Foundation Trust
2025
Great Ormond Street Hospital
2023
University College London
2023
University of Oxford
2014-2021
John Radcliffe Hospital
2021
Oxford University Hospitals NHS Trust
2014-2020
Medical Research Institute of New Zealand
2017-2018
Queen's Medical Centre
2015
Nottingham University Hospitals NHS Trust
2014
University of Nottingham
2014
Abstract Objective Hypogonadotropic hypogonadism is characterized by inadequate secretion of pituitary gonadotropins, leading to absent, partial, or arrested puberty. In males, classical treatment with testosterone promotes virilization but not testicular growth spermatogenesis. To quantify practices and efficacy, we systematically reviewed all studies investigating gonadotropins for the achievement pubertal outcomes in males hypogonadotropic hypogonadism. Design Systematic review...
Abstract Background Periostin has been shown to be a marker of Type 2 airway inflammation, associated with eosinophilia. It potential role in identifying asthmatics who may responsive treatment monoclonal antibody therapy directed against cytokines, such as interleukin (IL)-13, IL-4 receptor subunit-α and immunoglobulin E. The clinical utility periostin measurements depends on better understanding factors that affect serum levels, race. We aimed identify the ranges Chinese adults both...
We investigated the time course of change type-2 asthma biomarkers after a severe exacerbation. Blood eosinophils were lowest immediately treatment was initiated (0.07 vs 0.33×109/L, p<0.001) while serum IgE levels at their highest (339 249 U/L, p<0.001). Fractional exhaled Nitric Oxide 2 weeks (23 33 ppb, p=0.06) and periostin 1 week (45·9 50·9 ng/mL, A delay 4-8 following exacerbation is required if these are used to guide ongoing management patients with asthma. TRIAL REGISTRATION NUMBER:...
In asthma, serum periostin may potentially be used as a biomarker in the management of patients with Type-2 eosinophilic airway inflammation. However, influenced by factors other than Type 2 inflammation, confounding its interpretation. We aimed to measure change following bone injury. 102 adults without asthma were recruited into three groups: joint replacement surgery, long fracture, short fracture. Participants underwent seven measurements over 26 weeks after injury, and prior surgery...
The parents of a 2 year old boy notice difference in appearance his two eyes recent flash photograph, and they alert their paediatrician. A white red reflex is ‘leukocoria’—‘leukos’ Greek for ‘core’ pupil. Evaluation the useful screening test that should not be missed from routine paediatric examination. It quick, non-invasive only needs bright direct ophthalmoscope. An asymmetrical reflex—with abnormal colour, size, shape or positioning—can indicate need urgent ophthalmology referral. In...
Puberty is a life-changing time in the life of young person, with physical, psychological and social considerations. Amenorrhea derived from Latin: a—‘not’, men—‘month’ rhein—‘flow’, meaning absence monthly flow. In medical terms, it symptom describing menstruation. It can be classified as either primary or secondary. This article will focus solely on amenorrhea. Primary amenorrhea induce great anxiety both patient family often presents to general paediatrician. A thorough history...
A previously well 16 year old girl presented to acute medical admissions (walk-in assessment clinic) with a one week history of swelling her left eyelid. She was prescribed amoxicillin for presumed folliculitis. She re-presented later the emergency department because had steadily worsened over past two weeks. It tender palpation but there no pain movement. Visual acuity reduced in eye 6/9 (previously 6/6), and although appeared push “down side” she denied diplopia. Pupils were equal...
An 11 year old boy presented with focal motor seizures arising from the right hemisphere. Examination showed several sided facial features: a …
<h3>Aims</h3> The aim of this case report is to highlight the management focal seizures and demonstrate how routine investigations reveal an unusual aetiology. <h3>Introduction</h3> An 11-year-old boy presented with dyscognitive symptoms. His birth was uneventful, development normal. There no family history epilepsy. Examination revealed several right-sided facial features; a vertical linear indentation extending from brow hairline (linea morphea), subtle hemi-facial atrophy fewer lashes...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)