A5059242742- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory and Cough-Related Research
- Respiratory Support and Mechanisms
- IL-33, ST2, and ILC Pathways
- Neonatal Respiratory Health Research
- Mycobacterium research and diagnosis
- Sepsis Diagnosis and Treatment
- Tuberculosis Research and Epidemiology
- Eosinophilic Esophagitis
- Mobile Health and mHealth Applications
- Pain Mechanisms and Treatments
- Pleural and Pulmonary Diseases
- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Botulinum Toxin and Related Neurological Disorders
- Viral Infections and Immunology Research
- Intramuscular injections and effects
- Occupational exposure and asthma
- Cardiac Fibrosis and Remodeling
- Airway Management and Intubation Techniques
- Pediatric health and respiratory diseases
- Hemodynamic Monitoring and Therapy
- Inhalation and Respiratory Drug Delivery
- Infectious Diseases and Mycology
Capital and Coast District Health Board
2022-2025
Medical Research Institute of New Zealand
2017-2025
Victoria University of Wellington
2017-2019
East Sussex County Council
2019
Background: A noninvasive ventilation (NIV) mask has been designed to deliver NIV with expiratory washout improve efficacy of by optimizing clearance expired gases from the anatomic dead space. This study compared performance and comfort a novel investigational conventional during therapy. Methods: In this pilot crossover study, participants severe stable COPD attended single visit receive bi-level through 2 masks; mask. The order use was randomly allocated, each used for 60 min 30-60-min in...
ABSTRACT A 63‐year‐old male was diagnosed with a combination of three concurrent diseases: stage 4 lung adenocarcinoma, ipsilateral mycobacterium avium complex (MAC) pleural effusion, and advanced HIV. He has been successfully treated for each diagnosis. At 2 years from presentation he continues on immunotherapy, his culture clear MAC, an undetectable HIV viral load. An indwelling catheter inserted management the recurrent malignant effusion. We describe our approach to combined MAC related...
Background: When delivering high-flow nasal cannula (HFNC) therapy, automated oxygen titration increases time spent within a target SpO2 range compared with manually adjusted titration. This trial explored if this benefit is also achieved when CPAP or noninvasive ventilation (NIV) used. Methods: open label exploratory study randomized participants to manual using single respiratory support device capable of HFNC, CPAP, and NIV. Participants were hospital in-patients requiring supplemental...
Background Asthma is the most common chronic childhood respiratory condition globally. Inhaled corticosteroid (ICS)–formoterol reliever-based regimens reduce risk of asthma exacerbations compared with conventional short-acting β 2 -agonist (SABA) in adults and adolescents. The current limited evidence for anti-inflammatory reliever therapy children means it unknown whether these findings are also applicable to children. High-quality randomised controlled trials (RCTs) needed. Objective study...
Abstract Background Periostin has been shown to be a marker of Type 2 airway inflammation, associated with eosinophilia. It potential role in identifying asthmatics who may responsive treatment monoclonal antibody therapy directed against cytokines, such as interleukin (IL)-13, IL-4 receptor subunit-α and immunoglobulin E. The clinical utility periostin measurements depends on better understanding factors that affect serum levels, race. We aimed identify the ranges Chinese adults both...
We investigated the time course of change type-2 asthma biomarkers after a severe exacerbation. Blood eosinophils were lowest immediately treatment was initiated (0.07 vs 0.33×109/L, p<0.001) while serum IgE levels at their highest (339 249 U/L, p<0.001). Fractional exhaled Nitric Oxide 2 weeks (23 33 ppb, p=0.06) and periostin 1 week (45·9 50·9 ng/mL, A delay 4-8 following exacerbation is required if these are used to guide ongoing management patients with asthma. TRIAL REGISTRATION NUMBER:...
Introduction Asthma attacks are a leading cause of morbidity and mortality but preventable in most if detected treated promptly. However, the changes that occur physiologically behaviourally days weeks preceding an attack not always recognised, highlighting potential role for technology. The aim this study ‘DIGIPREDICT’ is to identify early digital markers asthma using sensors embedded smart devices including watches inhalers, leverage health environmental datasets artificial intelligence,...
In asthma, serum periostin may potentially be used as a biomarker in the management of patients with Type-2 eosinophilic airway inflammation. However, influenced by factors other than Type 2 inflammation, confounding its interpretation. We aimed to measure change following bone injury. 102 adults without asthma were recruited into three groups: joint replacement surgery, long fracture, short fracture. Participants underwent seven measurements over 26 weeks after injury, and prior surgery...
Background Closed-loop oxygen control systems automatically adjust the fraction of inspired (FiO 2 ) to maintain saturation (SpO within a predetermined target range. Their performance with low and high-flow therapies, but not non-invasive ventilation, has been established. We compared effect automated on achieving maintaining SpO range nasal high flow (NHF), bilevel positive airway pressure (bilevel) continuous (CPAP), in stable hypoxaemic patients chronic cardiorespiratory disease. Methods...
<b>Background:</b> A non-invasive ventilation (NIV) mask has been designed to deliver NIV with expiratory washout (EW) improve efficacy of by optimizing clearance expired gases from the anatomic dead-space. This study compared performance and comfort a novel investigational EW conventional during therapy. <b>Methods:</b> In this pilot cross-over study, participants severe stable chronic obstructive pulmonary disease (COPD) attended single visit receive bi-level through two masks; EW, mask....
Abstract Background Both inadequate and excessive administration of oxygen to acutely unwell patients results in risk harm. Guidelines recommend titration achieve a target saturation (SpO 2 ) range. Information regarding whether this is being achieved limited. Methods In two-centre non-interventional study we used continuous pulse oximetry medical over 24-h period determine the proportion time spent with SpO within prescribed range influenced by range, age, care high-dependency area number...
<b>Introduction:</b> Many candidate treatable traits have been proposed for the management of airways disease. However, trait prevalence in general asthma population and which are associated with future exacerbation risk unknown. <b>Methods:</b> The 17 their association was derived from previously reported New Zealand Respiratory Health Survey, ACTRN12610000666022. Adults aged 18-75 symptoms wheeze breathlessness, recruited a random sample, underwent detailed characterisation questionnaires,...
To estimate the proportion of adult diabetics with a skin to deltoid muscle distance (SDMD) > 25 mm, representing greater than standard needle length used for intramuscular COVID-19 vaccination, and assess whether anthropometric measurements predict ultrasound SDMD measurements. Non-interventional cross-sectional study. Single site, non-clinical setting, Wellington, New Zealand. One hundred participants (50 females) aged at least 18 years diagnosis diabetes. All completed The proportions mm...
<b>Background:</b> A noninvasive ventilation (NIV) mask has been designed to deliver NIV with expiratory washout (EW) improve efficacy of via clearing carbon dioxide (CO2) from anatomical deadspace. This study compared the performance and comfort this EW a standard during therapy. <b>Methods:</b> Sixteen participants severe stable chronic obstructive pulmonary disease (COPD) completed crossover study. Participants attended single visit receive, in random order, two 60-minute interventions...
High-concentration oxygen therapy causes increased arterial partial pressure of carbon dioxide (PaCO2) in patients with COPD, asthma, pneumonia, obesity and acute lung injury. The objective these studies was to investigate whether this physiological response occurs stable neuromuscular disease or kyphoscoliosis, bronchiectasis.Three randomised cross-over trials recruited kyphoscoliosis (n = 20), bronchiectasis 24), COPD 24). Participants were receive 50% 21% (air), each for 30 min, randomly...