A5075930107- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Inhalation and Respiratory Drug Delivery
- Pancreatitis Pathology and Treatment
- Respiratory Support and Mechanisms
- Pharmaceutical studies and practices
- Pancreatic and Hepatic Oncology Research
- Allergic Rhinitis and Sensitization
- Intensive Care Unit Cognitive Disorders
- Child and Adolescent Psychosocial and Emotional Development
- Kawasaki Disease and Coronary Complications
- Cardiac Arrest and Resuscitation
- Gastrointestinal disorders and treatments
- IL-33, ST2, and ILC Pathways
- COVID-19 Clinical Research Studies
- Orthopaedic implants and arthroplasty
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Surgical site infection prevention
- Orthopedic Infections and Treatments
- Biosensors and Analytical Detection
- Bee Products Chemical Analysis
- Climate Change and Health Impacts
- Diabetes Treatment and Management
- Neuroendocrine Tumor Research Advances
- Delphi Technique in Research
North Bristol NHS Trust
2025
Medical Research Institute of New Zealand
2015-2024
Asthma UK
2020
Amsterdam UMC Location University of Amsterdam
2016
Hammersmith Hospital
1992
University of Leicester
1987-1989
St George's Hospital
1983
In double-blind, placebo-controlled trials, budesonide–formoterol used on an as-needed basis resulted in a lower risk of severe exacerbation asthma than use short-acting β2-agonist (SABA); the was similar to that budesonide maintenance therapy plus SABA. The availability data from clinical trials designed better reflect practice would be beneficial.
Acetaminophen is a common therapy for fever in patients the intensive care unit (ICU) who have probable infection, but its effects are unknown.We randomly assigned 700 ICU with (body temperature, ≥38°C) and known or suspected infection to receive either 1 g of intravenous acetaminophen placebo every 6 hours until discharge, resolution fever, cessation antimicrobial therapy, death. The primary outcome was ICU-free days (days alive free from need care) randomization day 28.The number 28 did...
Endotoxaemia and circulating tumour necrosis factor are important prognostic factors in severe sepsis implicated the pathogenesis of septic shock. Because clinical pathological features acute pancreatitis similar to shock this study sought determine whether endotoxin were 38 patients with prognostically pancreatitis. Endotoxaemia, present 19/37 (51%) on day 1, was more common nonsurvivors than survivors (10/11, 91% v 9/26, 35%, p = 0.003). Day 1 serum concentrations higher a outcome (median...
Introduction The use of pressurised metered-dose inhalers (pMDIs) and asthma exacerbations necessitating healthcare reviews contribute substantially to the global carbon footprint healthcare. It is possible that a reduction in could be achieved by switching patients with mild from salbutamol pMDI reliever-based therapy inhaled corticosteroid-formoterol dry powder inhaler (DPI) reliever therapy, as recommended Global Initiative for Asthma. Methods This post hoc analysis included all 668 adult...
Abstract Fresh frozen plasma (FFP) has been proposed as a specific therapy for acute pancreatitis. Reduced mortality encountered in an uncontrolled clinical study and controlled experimental may be attributable to replenishment by FFP of the naturally occurring antiprotease system. To investigate this potential further, 202 patients presenting with pancreatitis were randomized receive (2 units daily 3 days) or similar volume colloid control part their intravenous fluid therapy. Clinical...
The clinical utility of serum periostin as a type 2 biomarker in asthma is limited by lack reference range values derived from population without respiratory disease.To derive age- and sex-related intervals for an adult or COPD.Serum levels were measured 480 individuals, comprising 60 female male adults each the 18- to 30-year, 31- 45-year, 46- 60-year 61- 75-year age groups. Key exclusion criteria included doctor's diagnosis asthma, chronic bronchitis COPD, history wheezing use inhalers...
Symptom-driven low-dose inhaled corticosteroid–formoterol is safe and effective in mild asthma has been recommended as one of the preferred treatment regimens at steps 1 2 2019 update Global Initiative for Asthma. However, there are no data on patient preferences this regimen. A subgroup participants PRACTICAL study (ACTRN12616000377437), a randomised controlled trial comparing symptom-driven budesonide–formoterol with maintenance budesonide plus as-needed terbutaline completed survey...
Objective To investigate the efficacy of topical 90% medical-grade kanuka honey and 10% glycerine (Honevo) as a treatment for rosacea. Design Randomised controlled trial with blinded assessment primary outcome variable. Setting Outpatient healthcare population from 5 New Zealand sites. Participants 138 adults aged ≥16, diagnosis rosacea, baseline Investigator Global Assessment Rosacea Severity Score (IGA-RSS) ≥2. 69 participants were randomised to each arm. 1 participant was excluded Honevo...
Objective To characterise the self-isolating household units (bubbles) during COVID-19 Alert Level 4 lockdown in New Zealand. Design, setting and participants In this cross-sectional study, an online survey was distributed to a convenience sample via Facebook advertising Medical Research Institute of Zealand’s social media platforms mailing list. Respondents were able share link their own by email. Results collected over 6 days from respondents living Zealand, aged 16 years over. Main...
Background Asthma is the most common chronic childhood respiratory condition globally. Inhaled corticosteroid (ICS)–formoterol reliever-based regimens reduce risk of asthma exacerbations compared with conventional short-acting β 2 -agonist (SABA) in adults and adolescents. The current limited evidence for anti-inflammatory reliever therapy children means it unknown whether these findings are also applicable to children. High-quality randomised controlled trials (RCTs) needed. Objective study...
Background International asthma guidelines recommend inhaled corticosteroid (ICS)/formoterol in preference to short-acting beta 2 -agonist (SABA) reliever-based regimens as reliever therapy adults and adolescents of all severities. A major limitation this recommendation is the absence randomised controlled trial (RCT) efficacy safety data for approach patients who continue use maintenance ICS. The anti-inflammatory effect ICS/formoterol on airway inflammation also not well characterised....
The SmartTouch Ventolin monitor (Adherium, Auckland, New Zealand) is an electronic for use with a metered dose inhaler, which records the date and time of inhaler actuations. This technology has potential to allow in-depth analysis patterns in clinical trial settings. aim this study was determine accuracy recording actuations.20 monitors were attached inhalers. Bench testing performed over 10-week period, reflect frame between visits trial. Inhaler actuations recorded paper diary, compared...
In adult asthma, combination inhaled corticosteroid (ICS)/fast-onset long-acting beta agonist (LABA) used solely as reliever therapy may represent an effective and safe alternative to ICS maintenance short-acting (SABA) therapy.To compare the efficacy safety of ICS/fast-onset LABA with SABA in adults asthma.A 52-week, open-label, parallel group, multicentre, phase III randomised controlled trial 1:1 randomisation either budesonide/formoterol Turbuhaler 200/6 µg, one actuation required for...
Background An as-needed combination preventer and reliever regimen was recently introduced as an alternative to conventional daily treatment for mild asthma. In a subgroup analysis of the PRACTICAL study, pragmatic randomised controlled trial budesonide–formoterol therapy versus maintenance budesonide plus terbutaline in adults with asthma, we reported that about two-thirds preferred therapy. The aim this study determine relative importance attributes associated these two asthma therapies...
As-needed low-dose combination budesonide-formoterol is recommended by asthma guidelines in many countries as an alternative to maintenance inhaled corticosteroids (ICS) for treatment of mild asthma, but there are few data on patient attitudes toward these regimens. This study explored the comparative implementation experiences and future preferences patients who had experienced two A subgroup adults randomised ICS or as-needed ICS-formoterol a multinational, 52-week open-label controlled...
Asthma is the most common chronic disease in children, many of whom are managed solely with a short-acting β2-agonist (SABA). In adults, evidence that budesonide-formoterol as sole reliever therapy markedly reduces risk severe exacerbations compared SABA alone has contributed to Global Initiative for recommending against monotherapy this population. The current lack children means it unknown whether these findings also relevant demographic. High-quality randomised controlled trials (RCTs)...
Abstract Background We aimed to determine the effect of sampling time during day on serum periostin levels in adult participants with and without asthma. Methods Serum was measured at 2-h intervals from 0800 1800 h 16 stable asthma prescribed inhaled corticosteroid long-acting beta-agonist therapy, otherwise healthy Mixed linear models were used compare zero (08:00 h) subsequent measurement for both groups. Results In non-asthma, mean (SD) continuously reduced 53.5 (13.6) ng/mL 50.9 (13.4)...