A5063384708- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Food Allergy and Anaphylaxis Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Drug-Induced Adverse Reactions
- Cardiac, Anesthesia and Surgical Outcomes
- Allergic Rhinitis and Sensitization
- Optical Imaging and Spectroscopy Techniques
- Long-Term Effects of COVID-19
- Inhalation and Respiratory Drug Delivery
- Cardiac and Coronary Surgery Techniques
- Mast cells and histamine
- COVID-19 Clinical Research Studies
- Pharmaceutical studies and practices
- Contact Dermatitis and Allergies
- Health Systems, Economic Evaluations, Quality of Life
- COVID-19 and healthcare impacts
- Diphtheria, Corynebacterium, and Tetanus
- Educational Innovations and Challenges
- FOXO transcription factor regulation
- Personality Disorders and Psychopathology
- Obsessive-Compulsive Spectrum Disorders
- Advanced Chemical Physics Studies
- Thermal Regulation in Medicine
- Pharmacological Effects and Assays
University of Manchester
1998-2024
Manchester University NHS Foundation Trust
2020-2024
Manchester Academic Health Science Centre
2022-2024
Victoria School of Management
2023
Wythenshawe Hospital
2023
Manchester University
2018-2023
NIHR Manchester Biomedical Research Centre
2022
University Foundation
2018-2021
Waikato Hospital
2020-2021
King Saud bin Abdulaziz University for Health Sciences
2021
The X-linked transcription factor FOXP3 is expressed by epithelial cells of organs including the breast, where it considered a tumour suppressor. chemokine receptor CXCR4 also regulates development breast cancer stimulating cell migration towards CXCL12-expressing sites metastatic spread. During activation, human T show reciprocal regulation and CXCR4. This study was designed to examine role plays in cancer, with particular focus on its potential regulate Human samples showed significantly...
Cerebral oximetry using near-infrared spectroscopy (NIRS) has been shown to reduce neurological dysfunction and hospital length-of-stay after adult cardiac surgery in some but not all studies. We audited maintaining cerebral saturations at or above baseline showed improved outcomes. Our hypothesis for this study was that our NIRS protocol would improve outcomes.This prospective, single centre, double-blinded controlled randomized 182 consecutive patients, scheduled cardiopulmonary bypass....
Background The COVID-19 pandemic has presented substantial new challenges to clinical and research teams. Our objective was analyse the experience of investigators delivery staff regarding response in order identify these as well solutions for future planning. Methods We conducted a survey diverse involved trials across UK. This delivered online centres linked NIHR Respiratory Translational Research Collaboration. Responses were analysed using formal thematic analysis approach common themes...
Recent findings suggest that αE expression is enriched on effector T cells and intestinal αE+ have increased of inflammatory cytokines. integrin a potential predictive biomarker for response to etrolizumab, monoclonal antibody against β7 targets both α4β7 αEβ7. We evaluated the prevalence localization as well total gene in healthy bowel disease patients.αE+ were identified ileal colonic biopsies by immunohistochemistry counted using an automated algorithm. Gene was assessed quantitative...
Abstract Background Effector cells assays provide an overall measure of responsiveness to allergen, but the lack reliable and high‐throughput limits clinical utility. We aimed develop a basophil activation test based on human progenitor cell‐derived basophils (PCB) investigate role PCB (PCBAT) in allergic diseases. Methods Progenitor were differentiated from CD34 + sensitized with sera subjects cat, peanut or atopic controls. Sensitized PCBs stimulated increasing concentrations corresponding...
ABSTRACT Background and objective Non‐selective beta‐blockers impair the bronchodilator response to beta 2 ‐agonists. Cardio‐selective 1 ‐blockers are less likely cause this effect, yet they remain relatively contraindicated in asthma. We investigated whether salbutamol is impaired during cardio‐selective ‐blocker treatment people with Methods A random‐order, double‐blind, placebo‐controlled, non‐inferiority, crossover study was conducted comparing up 5 mg bisoprolol daily for weeks matching...
Introduction: Cardiac surgery is associated with significant morbidity and longer length-of-stay (LOS) than most other surgeries. Regional cerebral oximetry (rSO2) using near-infrared spectroscopy (NIRS) on the patient’s forehead monitors oxygenation during cardiopulmonary bypass (CPB). Its purpose to detect manage periods of hypoxia which may otherwise go undetected, thereby reducing morbidity. But outcomes have been inconsistent, not all cardiac departments adopted this non-invasive,...
INVOS measures cerebral oxygen saturation. A 100 patient audit examining the efficacy of showed a reduction in mortality and post-operative length stay (LOS) against national statistics [1]. Our aim was to analyse cost effectiveness mixed coronary bypass (CABG) only cardiac surgery by comparing group control group.
Background The normal range of fractional exhaled nitric oxide ( F ENO ) is influenced by demographic factors. However, single, fixed cut-off values are used for clinical interpretation in children despite rapid growth. We aimed to define the during childhood and evaluate its utility a diagnostic setting. Method percentile charts were developed using data from nonasthmatic population-based birth cohort (Manchester Asthma Allergy Study). Children skin prick tested, measured at ages 8, 11,...
Amoxicillin induced mast cell degranulation mediated by FcεRI specific IgG: a new insight to beta-lactam allergy To the editor,Immediate drug hypersensitivity reactions (IDHR) beta-lactams (BL), referred here as (BLA), is defined development of symptoms such urticaria and bronchospasm within one hour exposure (1). Classical Type 1 immunoglobulin E (IgE)-mediated describes response which occurs minutes allergen in previously sensitised person. It has therefore been widely accepted that BLA...
The role of the third space woman leader is a blurry one (Denney, 2021). While making difference for students at heart our work, creating and leading teams in direction often not choosing from position that crosses many boundaries challenge invisible or unrecognized (Tay, Huijser, Dart, & Cathcart, 2023). No two women leaders arrived this by same path, but all have diverse range skills personal attributes to draw upon – formal qualifications, teaching experience, technical growth...
Background: Considerable variability exists between asthma diagnostic guidelines. We tested the performance characteristics of European Respiratory Society (ERS), National Institute for Health and Care Excellence (NICE) Global Initiative Asthma (GINA) guidelines diagnosis in adults.Methods: In this prospective observational study, participants referred from primary care with clinician-suspected underwent comprehensive investigation including: spirometry, bronchodilator reversibility,...
The diagnosis of asthma is often based on characteristic patterns symptoms in the absence an alternative explanation, resulting over and under diagnosis. Therefore, diagnostic guidelines usually recommend including confirmation variable airflow obstruction. Some using a sequence objective tests; however tests used, specific cut-off values specified order are yet to be validated. We aimed determine optimal series investigations diagnose asthma. also explore potential for novel small airways...
Objective Post-operative infection after cardiac surgery causes prolonged hospital stay and increased mortality. In patients with diabetes, peri-operative pre-operative glycemic control have been associated risk of post-operative infection. Saudi Arabia is the 7th highest country in world for prevalence diabetes. our surgical population incidence diabetes 77%. We were aware a high infections institution. The aim this work was to assess how related six-week Method retrospectively collected...