A5009513986- Microbial Inactivation Methods
- Microfluidic and Bio-sensing Technologies
- Electrostatic Discharge in Electronics
- Plasma Applications and Diagnostics
- Magnetic and Electromagnetic Effects
- Neuroscience and Neural Engineering
- Nanomaterials and Printing Technologies
- Electrical and Thermal Properties of Materials
- Gas Sensing Nanomaterials and Sensors
Old Dominion University
2019-2023
Abstract Ablation therapies aim at eradication of tumors with minimal impact on surrounding healthy tissues. Conventional pulsed electric field (PEF) treatments cause pain and muscle contractions far beyond the ablation area. The ongoing quest is to identify PEF parameters efficient but not stimulation. We measured electroporation cell killing thresholds for 150 ns–1 ms PEF, uni- bipolar, delivered in 10- 300-pulse trains up 1 MHz rates. Monolayers murine colon carcinoma cells exposed were...
Intense pulsed electric fields (PEF) are a novel modality for the efficient and targeted ablation of tumors by electroporation. The major adverse side effects PEF therapies strong involuntary muscle contractions pain. Nanosecond-range (nsPEF) less at neurostimulation can be employed to minimize such effects. We quantified impact electrode configuration, strength (up 20 kV/cm), repetition rate 3 MHz), bi- triphasic pulse shapes, duration (down 10 ns) on eliciting compound action potentials...
We prepared platinum nanoparticle ink usable for the fabrication of MEMS microheatersof high-temperature gas sensors and thermoresistors operating up to 450 °C present somepreliminary results on application in sensor microheater manufacturing. The inkconsists particles (3–8 nm) suspended ethylene glycol solution polyvinylpyrrolidone.The is both InkJet AerosolJet printers. annealing at temperature about 600 °Cleads formation uniform structure. experiments agingconfirm stability printed...
Reversing the pulse polarity, i.e., changing electric field direction by 180°, inhibits electroporation and electrostimulation nanosecond pulses (nsEPs). This feature, known as “bipolar cancellation,” enables selective remote targeting with nsEPs reduces neuromuscular side effects of ablation therapies. We analyzed biophysical mechanisms measured how cancellation weakens is replaced facilitation when are applied from different directions at angles 0 to 180°. Monolayers endothelial cells were...