A5101431361- Inflammatory Bowel Disease
- Immune Cell Function and Interaction
- Hepatocellular Carcinoma Treatment and Prognosis
- Renal cell carcinoma treatment
- Radiomics and Machine Learning in Medical Imaging
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Sarcoidosis and Beryllium Toxicity Research
- Cancer Immunotherapy and Biomarkers
- Liver Disease Diagnosis and Treatment
- IL-33, ST2, and ILC Pathways
- Attention Deficit Hyperactivity Disorder
- T-cell and B-cell Immunology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Botulinum Toxin and Related Neurological Disorders
- Microscopic Colitis
- Migraine and Headache Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
Icahn School of Medicine at Mount Sinai
2019-2024
Mount Sinai Hospital
2019
Baylor Scott & White Health
2016
Thomas Jefferson University
2012
Vedolizumab (VDZ) is a first-line treatment in ulcerative colitis (UC) that targets the α4β7- mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) axis. To determine mechanisms of action VDZ, we examined five distinct cohorts patients with UC. A decrease naïve B and T cells intestines gut-homing (β7 + ) plasmablasts circulation VDZ-treated suggested VDZ gut-associated lymphoid tissue (GALT). Anti-α4β7 blockade wild-type photoconvertible (KikGR) mice confirmed loss GALT size...
Targeting the α4β7-MAdCAM-1 axis with vedolizumab (VDZ) is a front-line therapeutic paradigm in ulcerative colitis (UC). However, mechanism(s) of action (MOA) VDZ remain relatively undefined. Here, we examined three distinct cohorts patients UC (n=83, n=60, and n=21), to determine effect on mucosal peripheral immune system. Transcriptomic studies protein level validation were used study drug MOA using conventional transgenic murine models. We found significant decrease colonic ileal naïve B...
Chronic migraine (CM) is a disabling disorder that significantly reduces quality of life. Guidelines recommend preventive medications as the standard care for patients with frequent migraine. Real-world analyses have shown adherence and persistence to oral (OMPMs) poor. However, previous research has focused on specific individual OMPM. Few studies date explored any This aims assess OMPM among newly diagnosed CM patients. A retrospective analysis medical pharmacy claims from Scott White...
Hepatocellular adenomas (HCAs) are benign lesions of the liver which can rarely undergo malignant transformation. We report a 26-year-old woman with no underlying disease found to have an incidental lesion on noncontrast CT during workup for gastric reflux. Follow up MRI revealed 10 cm gadoxetate-retaining within right hepatic lobe imaging features suggestive HCA vs focal nodular hyperplasia . Within this was focus arterial enhancement venous washout hepatocellular carcinoma (HCC) HCA, later...
Abstract Background Vedolizumab (VDZ) is a frontline drug for Ulcerative colitis (UC) and Crohn’s disease (CD) that targets integrin α4β7, gut-homing receptor. Despite significant use, the mechanism(s) of action (MOA) VDZ remain unclear. Methods Peripheral blood mononuclear cells (PBMC) from UC patients (n=43) paired intestinal biopsies in subset (n=12) were examined at week 0 (pre-infusion) 14, by multiparameter flow cytometry (FC). TNF inhibitor (TNFi)-treated served as controls. Drug MOA...