A5010883634- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Glycosylation and Glycoproteins Research
- Advanced Biosensing Techniques and Applications
- Medical Imaging and Pathology Studies
- Lung Cancer Treatments and Mutations
- Lymphoma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Ovarian function and disorders
- Phytochemicals and Antioxidant Activities
- School Choice and Performance
- Hypothalamic control of reproductive hormones
- RNA modifications and cancer
- Higher Education Research Studies
- Cancer Mechanisms and Therapy
- Cancer Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Botanical Research and Applications
- Chronic Lymphocytic Leukemia Research
- Phytochemistry and Bioactivity Studies
- Global Educational Reforms and Inequalities
- Phytochemistry and Bioactive Compounds
- interferon and immune responses
Zhujiang Hospital
2024-2025
Southern Medical University
2024-2025
Yancheng Institute of Technology
2024-2025
303 Hospital of People's Liberation Army
2022-2025
Beijing Chaoyang Emergency Medical Center
2024
Target (United States)
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2024
National Clinical Research
2024
Guangxi University
2021-2022
Guangxi Veterinary Research Institute
2022
Chemoimmunotherapy has evolved as a standard treatment for advanced non-small cell lung cancer (aNSCLC). However, inevitable drug resistance limited its efficacy, highlighting the urgent need biomarkers of chemoimmunotherapy. A three-phase strategy to discover, verify, and validate longitudinal predictive autoantibodies (AAbs) aNSCLC before after chemoimmunotherapy was employed. total 528 plasma samples from 267 patients anti-PD1 immunotherapy were collected, plus 30 independent...
Background Gut microbial metabolites are recognised as critical effector molecules that influence the development of colorectal cancer (CRC). Peptidoglycan fragments (PGFs) produced by microbiota play a crucial role in maintaining intestinal homeostasis, but their CRC remains unclear. Objective Here, we aimed to explore potential contribution PGFs tumourigenesis. Design The relative abundance peptidoglycan synthase and hydrolase genes was assessed metagenomic analysis. Specific faeces serum...
Abstract Background The identification of early plasma biomarkers for clinical outcomes and drug resistance has key importance risk stratification in anaplastic lymphoma kinase ( ALK )-positive advanced non-small cell lung cancer (NSCLC) patients. Moreover, it remains unclear whether the anti-angiogenic anlotinib can reverse ALK-tyrosine inhibitor (ALK-TKI) crizotinib, no research explored effect combined with crizotinib on -positive Methods In this study, 76 baseline longitudinal samples...
Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease, although disease stratification using in-depth plasma proteomics has not been performed to date. By measuring more than 1000 proteins in the of 147 DLBCL patients data-independent acquisition mass spectrometry and antibody array, were classified into four proteomic subtypes (PS-I-IV). Patients with PS-IV subtype worst prognosis had increased levels involved inflammation, including high expression metalloproteinase inhibitor-1...
Gonadotropin-inhibitory hormone (GnIH) is a reproductive inhibitor and an endogenous orexigenic neuropeptide that may be involved in energy homeostasis reproduction. However, whether GnIH molecular signal link of metabolism the system, thus, regulates activity as function state, still unknown. In present study, we investigated involvement glycolipid reproduction vivo, coupling between these two processes testis level. Our results showed chronic intraperitoneal injection into male mice not...
Inflatin G (1), a new aphidicolin analogue, together with seven known compounds inflatin A (2), B (3), (4), aphidicolin-17-monoacetate (5), gulypyrone (6), pyridoxatin rotamers (7) and (8), were isolated from the ascomycete fungus Tolypocladium inflatum. Their structures determined through NMR analyses circular dichroism data of in situ formed [Rh₂(OCOCF₃)₄] complexes. Compounds 1, 4, 5, 7, 8 showed modest cytotoxicity against four human cancer cell lines A549, CNE1-MP1, A375, MCF-7.
Background: Crizotinib established the position of anaplastic lymphoma kinase-tyrosine kinase inhibitors (ALK-TKI) in treatment non-small cell lung cancer (NSCLC) while therapy- resistance hindered those patients from benefitting continuously treatment. CT-707 is an inhibitor ALK/focal adhesion (FAK) and IGFR-1. H2228CR (crizotinib resistance, CR) H3122CR NSCLC lines were generated parental line H2228 (EML4-ALK, E6a/b:A20, variant 3) H3122(EML4-ALK, E13:A20, 1), respectively. Methods: We...
Autoantibodies (AAbs) targeted tumor-associated antigens (TAAs) have the potential for early detection of breast cancer. Here, 574 early-stage cancer (ES-BC) patients containing 4 subtypes (Luminal A, Luminal B, HER2+, TN), 126 benign disease (BBD) patients, and 199 normal healthy controls (NHC) were separated into three-phases to discover, verify, validate AAbs. In discovery phase using high-throughput protein microarray, 37 AAbs with sensitivity 31.25%-86.25% specificity over 73% in ES-BC,...
The dominant white phenotype in domestic pigs is caused by two mutations the KIT gene: a 450 kb duplication containing entire gene together with flanking sequences and one splice mutation G:A substitution intron 17. purpose of this study was to establish simple, rapid method determine genotype pigs. First, detect copy number variation (CNV), primers for exon 2 gene, along TaqMan minor groove binder (MGB) probe, were designed. single-copy estrogen receptor (ESR), used as an internal control....
Abstract Background R‐CHOP (rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone) is a standard first‐line treatment for diffuse large B‐cell lymphoma (DLBCL). However, 20%–40% of patients survive less than 5 years. Novel prognostic biomarkers remain in demand. Methods Baseline plasma autoantibodies (AAbs) were assessed 336 DLBCLs. In the discovery phase ( n = 20), high‐density antigen microarray (∼21,000 proteins) was used to expound AAb profiles. verification 181),...
Abstract Background: Early diagnosis is critical to lung adenocarcinoma patients’ survival but faces inadequacies in convenient early detection. Methods: We applied a comprehensive microarray of 130,000 peptides detect “autoantibody signature” that autoantibodies binding mimotopes for detection stage 0–I LUAD. Plasma samples were collected from 147 early-stage (Early-LUAD), 108 benign disease (BLD), and 122 normal healthy controls (NHC). Clinical characteristics, low-dose CT (LDCT),...