A5088830586- Parasites and Host Interactions
- Parasitic Infections and Diagnostics
- Immune cells in cancer
- Neonatal Respiratory Health Research
- Analytical Chemistry and Sensors
- Proteoglycans and glycosaminoglycans research
- Silicon Nanostructures and Photoluminescence
- Semiconductor materials and devices
- Extracellular vesicles in disease
- Epilepsy research and treatment
- COVID-19 and Mental Health
- Cellular transport and secretion
- Gut microbiota and health
- Eosinophilic Esophagitis
- Ubiquitin and proteasome pathways
- S100 Proteins and Annexins
- Parasite Biology and Host Interactions
- Neuroscience and Neuropharmacology Research
- Reconstructive Surgery and Microvascular Techniques
- Invertebrate Immune Response Mechanisms
- Glycosylation and Glycoproteins Research
- Pharmacological Effects and Toxicity Studies
- Immune Cell Function and Interaction
- Axon Guidance and Neuronal Signaling
- Long-Term Effects of COVID-19
University of Manchester
1979-2022
Wellcome Centre for Cell-Matrix Research
2018-2022
Royal Brisbane and Women's Hospital
2022
The University of Melbourne
2021
The Royal Melbourne Hospital
2021
Manchester Academic Health Science Centre
2018-2019
Centre for Inflammation Research
2019
Health Sciences Centre
2018
Thomas Jefferson University
2016-2017
Sidney Kimmel Cancer Center
2016
Although the growth factor progranulin was discovered more than two decades ago, functional receptor remains elusive. Here, we that EphA2, a member of large family Ephrin tyrosine kinases, is signaling for progranulin. Recombinant bound with high affinity to EphA2 in both solid phase and solution. Interaction caused prolonged activation receptor, downstream stimulation mitogen-activated protein kinase Akt, promotion capillary morphogenesis. Furthermore, found an autoregulatory mechanism...
Infection by soil transmitted parasitic helminths, such as Trichuris spp, are ubiquitous in humans and animals but the mechanisms determining persistence of chronic infections poorly understood. Here we show that p43, single most abundant protein T. muris excretions/secretions, is non-immunogenic during infection has an unusual sequence structure containing subdomain homology to thrombospondin type 1 interleukin (IL)-13 receptor (R) α2. Binding p43 IL-13, key effector cytokine responsible...
Whipworms are large metazoan parasites that inhabit multi-intracellular epithelial tunnels in the intestine of their hosts, causing chronic disease humans and other mammals. How first-stage larvae invade host epithelia establish infection remains unclear. Here we investigate early events using both Trichuris muris infections mice murine caecaloids, first in-vitro system for whipworm organoid model live helminths. We show degrade mucus layers to access cells. In syncytial tunnels, completely...
Abstract Purpose To assess the impact of early sotrovimab treatment versus no on risk developing post-acute sequelae COVID-19 (PASC; long COVID) in patients (age ≥ 12 years) with at high for progression to severe disease. Methods Retrospective cohort study using US National COVID Cohort Collaborative (N3C) data. Phase 1 identified and assessed multiple definitions PASC; 2 evaluated effectiveness reducing PASC, utilizing from 1. Average effect treated (ATT)-weighted Cox proportional hazards...
The application to silicon of an electrochemical technique, allowing automatic profiling over large depths and a wide range carrier concentration, is described.
Trichuris trichiura (whipworm) is one of the four major soil-transmitted helminth infections man, affecting an estimated 465 million people worldwide. An effective vaccine that induces long-lasting protective immunity against T. would alleviate morbidity associated with this intestinal-dwelling parasite, however lack known host antigens has hindered development. Here, we show vaccination ES products stimulates protection chronic infection in male C57BL/6 mice. We also provide a framework for...
Abstract Background A poor evidence basis exists regarding the objective donor site morbidity associated with osseous free flap harvest. This study prospectively assessed harvest for fibula, scapula, and iliac crest (DCIA) sites. Methods single‐site, prospective cohort clinical research was conducted. Sixty‐four patients were recruited between 2017 2021. Patients using a specific assessment tool pre‐operatively, again >12 months post‐operatively. Results There significant reduction...
The electrical behavior of the electrolyte‐silicon interface has been investigated. , and anodic dissolution phenomena are discussed in relation to feasibility using for determination carrier concentration profiles silicon structures; specimen electrochemical presented compared with corresponding spreading resistance profiles.
Abstract Whipworms are large metazoan parasites that inhabit distinct multi-intracellular epithelial burrows described as syncytial tunnels, in the intestine of their hosts. How first-stage larvae invade host epithelia and establish infection remains unclear. Here, we investigate early events both using Trichuris muris infections mice murine caecaloids, first in-vitro system for whipworm infection. We show degrade mucus layers to access cells. In completely intracellular but woven through...