A5091272302- Spectroscopy and Chemometric Analyses
- Spectroscopy Techniques in Biomedical and Chemical Research
- Oral Health Pathology and Treatment
- Molecular Biology Techniques and Applications
- Microbial Inactivation Methods
- Bacillus and Francisella bacterial research
- Bee Products Chemical Analysis
- Oral microbiology and periodontitis research
- Cancer and biochemical research
- History and advancements in chemistry
- Chemical Thermodynamics and Molecular Structure
Technological University Dublin
2019-2025
Centre for Research in Engineering Surface Technology
2017
Introducdon I. Reference materials for absorbance/transmi.ttancemeasurements Ultravialet absorbance 1. Potassium dichromate in aqueous sulphuric acid solution Visible 2. Copper sulphate aeid .3. Cobalt aDIIIOnium 4. and nickel nitrates perchloric 5. Coloured glass filters Infrared transmittance 6. Rotating sectors .II.. materiale wavelength/wavenumber measurements Ul traviolet region • 1.Low pressure discharge lamps containing cadmium, mercury or zinc Hollow cathode Holmium (III) ions .4....
A standardised protocol for sample collection, preparation, spectral acquisition and data processing future studies of oral exfoliated cells based on Raman microspectroscopy.
Human saliva is a unique biofluid which can reflect the physiopathological state of an individual. The wide spectrum molecules present in saliva, compounded by close association salivary composition to serum metabolites, provide valuable information for clinical diagnostic applications through highly sensitive vibrational spectroscopic techniques such as Raman spectroscopy. However, nature terms collection and patient-related characteristics, be considered factors may strongly affect...
Abstract This study demonstrates the efficacy of Raman micro‐spectroscopy oral cytological samples for differentiating dysplastic, potentially malignant lesions from those normal, healthy donors. Cells were collected using brush biopsy donors (n = 20) and patients attending a Dysplasia Clinic 20). Donors sampled at four different sites (buccal mucosa, tongue, alveolus, gingiva), to ensure matched normal all lesions, while patient taken clinically evident, histologically verified dysplastic...
Abstract Field cancerisation (FC) is potentially an underlying cause of poor treatment outcomes oral squamous cell carcinoma (OSCC). To explore the phenomenon using Raman microspectroscopy, brush biopsies from buccal mucosa, tongue, gingiva and alveolus healthy donors (n = 40) malignant lesions (PML) Dysplasia Clinic patients were examined. Contralateral normal samples 38) also collected patients. spectra acquired nucleus cytoplasm each cell, subjected to partial least squares‐discriminant...
The gold standard diagnosis of oral pre-cancer/cancer is an invasive biopsy followed by a histological examination, which may present psychological trauma and risk infection to patients. Moreover, multiple biopsies are often required monitor precancer lesions' progression. With the aim reducing need for biopsies, this study was undertaken identify pre-cancerous lesions using minimally brush saliva samples, analysed Raman spectroscopy.
Oral cancer has a poor prognosis of only 50% even in the light current technological advances. This may be attributed to still unmet clinical need diagnose oral pre-cancer and dysplasia. Raman spectroscopy, which can detect subtle biochemical changes, been explored for diagnosis cancer. study aims address by exploiting high amplification factor Surface Enhanced Spectroscopy (SERS) analyse saliva samples 10 healthy controls patients with Furthermore, this technique was compared conventional...