A5030742206- Prostate Cancer Treatment and Research
- Cancer Immunotherapy and Biomarkers
- Pancreatic function and diabetes
- Immune Cell Function and Interaction
- Axon Guidance and Neuronal Signaling
- Multiple Myeloma Research and Treatments
- Wnt/β-catenin signaling in development and cancer
- Congenital heart defects research
- Hippo pathway signaling and YAP/TAZ
- Cancer Cells and Metastasis
- Cell Adhesion Molecules Research
- Hypothalamic control of reproductive hormones
- Ovarian function and disorders
- Cell death mechanisms and regulation
- Reproductive System and Pregnancy
- Cancer, Lipids, and Metabolism
- Radiopharmaceutical Chemistry and Applications
- Immunotherapy and Immune Responses
Cardiff University
2020-2024
Institute of Cancer Research
2021-2024
National Health Service
2014
As we age, our tissues are repeatedly challenged by mutational insult, yet cancer occurrence is a relatively rare event. Cells carrying cancer-causing genetic mutations compete with normal neighbors for space and survival in tissues. However, the mechanisms underlying mutant-normal competition adult relevance of this process to remain incompletely understood. Here, investigate how pancreas maintains tissue health vivo following sporadic expression oncogenic Kras (KrasG12D), key driver...
Kisspeptin is a recently identified hormone encoded by the KISS1 gene, playing critical role in human reproduction. Plasma kisspeptin levels rise dramatically during normal pregnancy due to placental synthesis, which implicates it as potential tool for assessing risks of complications. No previous prospective study has investigated association between plasma and risk miscarriage.The objective was determine whether single or serum chorionic gonadotropin (hCG) measurement asymptomatic women...
The widespread use of potent androgen receptor signaling inhibitors (ARSIs) has led to an increasing emergence AR-independent castration-resistant prostate cancer (CRPC), typically driven by loss AR expression, lineage plasticity, and transformation cancers (PCs) that exhibit phenotypes neuroendocrine or basal-like cells. anti-apoptotic protein BCL2 is upregulated in may be a therapeutic target for this aggressive PC disease subset. There unmet clinical need, therefore, clinically...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Summary As we age, our tissues are repeatedly challenged by mutational insult, yet cancer occurrence is a relatively rare event. Cells carrying cancer-causing genetic mutations compete with normal neighbours for space and survival in tissues. However, the mechanisms underlying mutant-normal competition adult relevance of this process to remain incompletely understood. Here, investigate how pancreas maintains tissue health vivo following sporadic expression oncogenic Kras ( KrasG12D ), key...