To investigate whether immune mediated diseases (IMD) are more frequent in patients with inflammatory bowel disease (IBD).In this population based registry study, a total of 47325 IBD were alive and registered the Danish National Patient Registry on December 16, 2013. Controls randomly selected from Civil Registration System (CRS) matched for sex, age, municipality. We used ICD 10 codes to identify diagnoses included patients. The was divided into three subgroups: Ulcerative colitis (UC),...

Active inflammatory bowel disease (IBD) during conception and pregnancy may increase the risk of adverse birth outcomes. Former studies have examined heterogeneous groups women with varying degrees IBD severity. We aimed to examine effect active on outcomes in a more homogeneous group moderate severe course. Since Denmark, is an indication for use anti-tumor necrosis factor-α therapy, we all who used factor therapy pregnancy. identified nationwide cohort 219 singleton pregnancies treated...

Infliximab (IFX) maintenance therapy for Crohn's disease (CD) is administered every 8 weeks, but inter-patient variation in optimal treatment intervals may exist.To assess, a prospective pilot study, the efficacy, safety and quality of life (QoL) IFX scheduled through web-based self-monitoring activity.Twenty-seven CD patients were enrolled received standardised education web-training. Using http://www.cd.constant-care.dk concept, recorded their activity faecal calprotectin weekly. From...

Summary Background Therapeutic management of inflammatory bowel diseases (IBD) is rapidly evolving, with an expanding armoury biological drugs at our disposal. However, real‐world findings about treatment persistence and the impact biologicals on surgery remain inconsistent. Aims This study aimed to investigate trends in use rates a nationwide cohort biological‐naïve IBD patients. Methods Patients who initiated between 2011 2018 were identified Danish National Patient Registry. Data...

Abstract Background and Aim Pan-enteric capsule endoscopy [PCE] is a highly sensitive but time-consuming tool for detecting pathology. Artificial intelligence [AI] algorithms might offer possibility to assist in the review reduce analysis time of PCE. This study examines agreement between PCE assessments aided by AI technology standard evaluations, patients suspected Crohn’s disease [CD]. Method PCEs from prospective, blinded, multicentre study, including CD, were processed deep learning...

Potassium channels, KV1.3 and KCa3.1, have been suggested to control T-cell activation, proliferation, cytokine production may thus constitute targets for anti-inflammatory therapy. Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by excessive infiltration production. It unknown if KCa3.1 in the inflamed mucosa are markers of active UC. We hypothesized that correlate with activity patients UC.Mucosal biopsies were collected from UC (n=33) controls (n=15). Protein...

AbstractBackground: Functional dyspepsia (FD) is defined as persistent or recurrent pain/discomfort centred in the upper abdomen, where no structural explanation for symptoms found. The role of drug treatment remains controversial. aim this study was to evaluate effect omeprazole 20 mg twice daily (b.i.d) and test methods symptom assessment. Methods: 197 patients fulfilling criteria FD were randomly allocated double-blind with b.i.d ( n = 100) placebo 97) 14 days. Patients a known...

There exist several risk stratification systems for predicting mortality of emergency patients. However, some are complex in clinical use and others have been developed using suboptimal methodology. The objective was to evaluate the capability staff at a medical admission unit (MAU) intuition predict in-hospital acutely admitted patients.This is an observational prospective cohort study adult patients (15 years or older) MAU regional teaching hospital. nursing physicians predicted upon...

Fecal calprotectin (FC) is a biomarker used for assessing disease activity among IBD patients. Sparse knowledge exists as to whether FC correlates with clinical during pregnancy. Our aim was assess and selected biomarkers in women moderate-severe correlate them scores pregnant women. We identified nationwide cohort of 219 singleton pregnancies (all treated anti–tumor recrosis factor–α [anti-TNF-α] therapy pregnancy), we reviewed the medical records extract details information on biomarkers....

No studies have examined the efficacy of assisted reproductive technology (ART) treatment in women with rheumatoid arthritis. Therefore, we chance live birth after ART arthritis compared without arthritis.Our cohort study is based on nationwide Danish health registries, comprising all an embryo transfer during 1 January 1994 through 30 June 2017. The cohorts comprised 1149 transfers arthritis, and 198 941 Our outcome was per transfer, controlled for multiple covariates analyses. In...

Magnetic resonance enterocolonography (MREC) and pan-enteric capsule endoscopy (CE) offers visualization of the entire gastrointestinal tract in a single examination. We examined diagnostic accuracy MREC CE patients with suspected Crohn's disease (CD).In prospective, blinded, multicenter study, we included clinically CD. Patients were MREC, CE, ileocolonoscopy (IC) within 2 weeks. The primary outcome was per patient sensitivity, specificity, for ileocolonic IC served as reference...

Summary Objective In patients with elderly (≥60 years) onset inflammatory bowel disease (IBD), we studied initiation of medications, drug persistency and surgeries. Design A nationwide cohort study based on Danish registries, comprising incident IBD ≥18 years from 1995 to 2020 ( N = 69,039). Patients were divided into 19,187) adult 49,852). Outcomes thiopurines, 5‐ASA, biologics corticosteroids within 1 5 after diagnosis, for those who initiated estimated persistency. Surgeries examined...

Panenteric capsule endoscopy (PCE) is a minimally invasive modality that may replace ileocolonoscopy (IC) in selected patients with Crohn's disease (CD). This study aimed to evaluate the dynamics of repeated assessment PCE receiving medical treatment for ileocolonic CD.

Interruption in chest compressions during cardiopulmonary resuscitation can be characterized as no flow ratio (NFR) and the importance of minimizing these pauses compression has been highlighted recently. Further, documentation performance reported to insufficient there is a lack identification important issues where future efforts might beneficial. By implementing situ simulation we created model evaluate performance. The aims study were feasibility applied method, examine differences...

Resources used in surveillance colonoscopies are taking up an increasing proportion of colonoscopy capacity. Colon capsule endoscopy (CCE) is a promising technique for noninvasive investigation the colon. We aimed to investigate CCE as possible filter colonic with primary outcome reducing number colonoscopies.Patients scheduled follow-up were subjected and only supplemental conventional if significant pathology was detected or examination incomplete. Significant defined more than two small...

Abstract Aim The aim of this work was to estimate the prevalence iron deficiency in patients diagnosed with colorectal cancer (CRC) and clarify its association patient‐ tumour‐related characteristics. Method This a single‐centre registry‐based cohort study. Iron status routinely evaluated upon diagnosis CRC, these data were coupled tumour‐specific from Danish CRC Group Registry (2013–2018). Data analysed using multivariate logistic regression. Results Out 846 patients, 543 (64%) deficient....

Abnormal sleep is commonly observed in the ICU and associated with delirium increased mortality. If sedation necessary, it often performed gamma-aminobutyric acid agonists such as propofol or midazolam leading to an absence of restorative sleep. We aim evaluate effect dexmedetomidine on quality quantity.

Abstract Background Minimally invasive modalities have shown significant potential for monitoring disease severity and treatment response in Crohn’s (CD). Several magnetic resonance imaging (MRI) scoring systems been validated research settings. However, these calculations are time-consuming, which limit their widespread adoption clinical practice. This analysis evaluated patients with active CD using simple markers compared them to complex multifactorial scores. Methods A post-hoc was...

Prior studies indicate that serum calprotectin (SC) and plasma (PC) can be used as biomarkers in Crohn's disease (CD). The aim of this study was to investigate the diagnostic accuracy SC PC patients with a clinical suspicion CD. This biobank included from prospective, blinded, multicenter examining minimally invasive modalities for diagnosing Patients had standardized work-up including ileocolonoscopy, pan-enteric capsule endoscopy, blood samples within 2-week period. Plasma were stored at -...

Neutron diffraction measurements on amorphous selenium have been performed at 293 and 80 K. Careful analyses of the instrumental corrections were made to avoid systematic errors in measured structure factor S (κ) wave vector region 0 ? κ 12 Å−1. As a result data treatment, neutron scattering cross sections are determined be σcoh = 8.4±0.1 b σinc 0.1±0.1 b. Using fact that for large κ’s is by short distances sample, new method extrapolation experimental until convergence proposed. This allows...