A5063349964- Protein Structure and Dynamics
- Enzyme Structure and Function
- Alzheimer's disease research and treatments
- Proteins in Food Systems
- COVID-19 epidemiological studies
- Glycosylation and Glycoproteins Research
- Protein purification and stability
- Protein Interaction Studies and Fluorescence Analysis
- Bioinformatics and Genomic Networks
- Mass Spectrometry Techniques and Applications
- COVID-19 Clinical Research Studies
- Monoclonal and Polyclonal Antibodies Research
- Lipid Membrane Structure and Behavior
- SARS-CoV-2 and COVID-19 Research
Jagiellonian University
2019-2024
Protein solubility is based on the compatibility of specific protein surface with polar aquatic environment. The exposure residues to promotes protein’s in environment also influences folding process by favoring centralization hydrophobic simultaneous residues. degree residue distribution, model concentration center molecule, determined sequence amino acids chain. fuzzy oil drop enables quantification hydrophobicity distribution observed a form fully consistent Gaussian 3D function, which...
The issue of changing the structure globular proteins into an amyloid form is in focus researchers' attention. Numerous experimental studies are carried out, and mathematical models to define essence transformation sought. present work focuses on hydrophobic core amyloids. ordering described by a 3D Gaussian distribution analog hydrophobicity spherical micelle. Amyloid fibril ribbon-like micelle made up numerous individual chains, each representing flat structure. within single chain...
Proteins with a high degree of sequence similarity representing different structures provide key to understand how protein codes for 3D structure. An analysis using the fuzzy oil drop model was carried out on two pairs proteins secondary and identities. It has been shown that distributions hydrophobicity these are approximated well single Gaussian function. In other words, similar sequences fold into structures, however, alternative also have symmetric monocentric hydrophobic cores. should...
In the search for new carriers capable of transporting toxic drugs to a target, particular attention has been devoted supramolecular systems with ribbon-like micellar structure which Congo red is an example. A special promise possible use such directing target emerges from their affinity immune complexes and as independent property, binding many organic compounds including by intercalation. Serum albumin also appeared able bind particles systems. It may protect them against dilution in...
<b>Objective:</b> This paper contains an overview of information related to the origin SARS-CoV-2 virus, its characteristics, including mutational variability, and monitoring virus's presence in human population. <br><b>Methods:</b> A review medical biological literature from PubMed/MEDLINE databases 1998 2024 was performed regarding research on SARS viruses, particularly SARS-CoV-2. <br><b>Results conclusions:</b> At end 2019, cases a new...
Protein structure is the result of high synergy all amino acids present in protein. This an overall strategy for adapting a specific protein structure. It compromise between two trends: The optimization non-binding interactions and directing folding process by external force field, whose source water environment. geometric parameters structural form polypeptide chain local radius curvature that dependent on orientation adjacent peptide bond planes (result respective Phi Psi rotation) allow...
The fuzzy oil drop model suggests that the tertiary conformation of a protein - particularly globular one can be likened to spherical micelle. During folding process, hydrophilic residues are exposed on surface, while hydrophobic retained inside protein. resulting hydrophobicity distribution mathematically modeled as 3D Gaussian. is strikingly effective in explaining properties type II antifreeze proteins and fast-folding proteins, well vast majority autonomous domains. This work aims...
There is an opinion in professional literature that edge-strands β-sheet are critical to the processes of amyloid transformation. Propagation fibrillar forms mainly takes place on basis type interactions. In many proteins, edge strands represent only a partially matched form β-sheet. Therefore, edge-strand slightly distorted forms. The assessment level arrangement can be carried out based studying secondary structure as well hydrophobic core. For this purpose, fuzzy oil drop model was used...