A5103166180- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Medical Imaging Techniques and Applications
- Cancer-related molecular mechanisms research
- Cerebrovascular and Carotid Artery Diseases
- Cervical and Thoracic Myelopathy
- Aortic Disease and Treatment Approaches
- Prostate Cancer Treatment and Research
- MicroRNA in disease regulation
- Spinal Cord Injury Research
- Inflammatory Bowel Disease
- Advanced Neuroimaging Techniques and Applications
- Sarcoidosis and Beryllium Toxicity Research
- Scoliosis diagnosis and treatment
- Brain Metastases and Treatment
- Characterization and Applications of Magnetic Nanoparticles
- Cardiac Valve Diseases and Treatments
- Nerve Injury and Rehabilitation
- Autoimmune and Inflammatory Disorders
- Radiation Dose and Imaging
- Kawasaki Disease and Coronary Complications
- Intracranial Aneurysms: Treatment and Complications
- NF-κB Signaling Pathways
- Spinal Fractures and Fixation Techniques
- Mechanisms of cancer metastasis
Sun Yat-sen University
2016-2023
The First Affiliated Hospital, Sun Yat-sen University
2016-2023
Sanming University
2011
To investigate whether radiomics features extracted from multi-parametric MRI combining machine learning approach can predict molecular subtype and androgen receptor (AR) expression of breast cancer in a non-invasive way.Patients diagnosed with clinical T2-4 stage March 2016 to July 2020 were retrospectively enrolled. The subtypes AR pre-treatment biopsy specimens assessed. A total 4,198 the pre-biopsy (including dynamic contrast-enhancement T1-weighted images, fat-suppressed T2-weighted...
Bone metastasis is associated with cancer-related death in patients prostate cancer (PCa). Long noncoding RNAs (lncRNAs) play critical roles tumor progression of PCa. Nevertheless, the biological function lncRNAs PCa bone remains unclear. PCAT7 was identified as a metastasis-related lncRNA via analyzing TCGA dataset. Meanwhile, found to be elevated primary tissues and status poor prognosis Functionally, our results reveal that overexpression promotes vivo, well migration, invasion, EMT cells...
Clinically, prostate cancer (PCa) exhibits a high avidity to metastasize bone. Myc-associated zinc-finger protein (MAZ) is well-documented oncogene involved in the progression and metastasis of multiple types, even PCa. However, clinical significance biological roles MAZ bone PCa remain unclear. expression was examined tissues with metastasis, without metastatic by real-time PCR immunohistochemistry (IHC), respectively. Statistical analysis performed evaluate correlation between...
Background: The reciprocal repressive loop between ZEB1 and miRNAs has been extensively reported to play an important role in tumor progression metastasis of various human types. aim this study was elucidate the underlying mechanism double-negative feedback ZEB1and miR-33a-5p bone prostate cancer (PCa). Methods: expression examined 40 metastatic 165 non-bone PCa tissues by real-time PCR. Statistical analysis performed evaluate clinical correlation clinicopathological characteristics, overall...
The prime issue derived from prostate cancer (PCa) is its high prevalence to metastasize bone. MicroRNA-204-5p (miR-204-5p) has been reported be involved in the development and metastasis a variety of cancers. However, clinical significance biological functions miR-204-5p bone PCa are still not yet. In this study, we find that expression reduced tissues serum sample with compared without metastasis, which associated advanced clinicopathological characteristics poor metastasis-free survival...
<h3>BACKGROUND AND PURPOSE:</h3> Some retrospective studies have found that the aneurysm wall enhancement on high-resolution MR vessel postgadolinium T1WI has potential to distinguish unstable aneurysms. This study aimed identify hemodynamic characteristics differ between enhanced and nonenhanced areas of T1WI. <h3>MATERIALS METHODS:</h3> TOF-MRA 25 patients were fused localize area wall. Using computational fluid dynamics, we studied models. Mean static pressure, mean shear stress,...
Aim: After neoadjuvant chemotherapy (NACT), tumor shrinkage pattern is a more reasonable outcome to decide possible breast-conserving surgery (BCS) than pathological complete response (pCR). The aim of this article was establish machine learning model combining radiomics features from multiparametric MRI (mpMRI) and clinicopathologic characteristics, for early prediction prior NACT in breast cancer. Materials Methods: This study included 199 patients with cancer who successfully completed...
Neurite orientation dispersion and density imaging (NODDI) is a new diffusion MRI technique that has rarely been applied for glioma grading. The purpose of this study was to quantitatively evaluate the diagnostic efficiency NODDI in tumour parenchyma (TP) peritumoural area (PT) grading gliomas detecting isocitrate dehydrogenase-1 (IDH-1) mutation status. Forty-two patients (male: 23, female: 19, mean age: 44.5 y) were recruited underwent whole brain examination. Intracellular volume fraction...
Cortical vein thrombosis (CVT) receives little attention in adult patients with cerebral venous sinus (CVST). This study aimed to investigate the clinical and radiological features of CVST concomitant CVT. From May 2009 2016, we recruited 44 (diagnosed within 1 month onset; 33.8 ± 14.0 years age, 28 males). CVT was primarily confirmed using computed tomography venography magnetic resonance imaging sequence contrast enhanced three dimensions magnetization prepared rapid acquisition gradient...
In this study, we investigated the utility of native T1 mapping in differentiating between various grades fibrosis and compared its diagnostic accuracy to magnetization transfer imaging (MTI) a rat model CD. Bowel specimens (64) from 46 CD rats undergoing MTI were enrolled. The longitudinal relaxation time (T1 value) normalized ratio (MTR) none-to-mild moderate-to-severe fibrotic bowel walls confirmed by pathological assessments. results showed that correlation value (r = 0.438, p < 0.001)...
Fibrostenosis is a serious complication of Crohn's disease (CD), affecting approximately one-half all patients. Surgical resection the typical clinical end due to ineffective antifibrotic therapy mainly through anti-inflammatory treatment and fibrosis can be reverted only at early stages. Mover, human fibrotic disorders known associated with aging process. Thus, accurate monitoring progression crucial for CD management as well benefit related fibrosis. The excessive deposition type I...
Cervical spondylotic myelopathy (CSM) is a degenerative condition of the spine that caused by static and dynamic compression spinal cord. However, mechanisms motor somatosensory conduction, as well pathophysiological changes at neck positions remain unclear. This study aims to investigate interplay between neurophysiological hemodynamic responses in CSM condition, pathological basis behind. We first demonstrated patients had more severe evoked potentials (DMEPs) deteriorations upon flexion...
Our study suggests that the percentage change for second visits relative to baseline of enhanced tumor volume-based imaging metrics DCE-MRI can quantify heterogeneous changes within as an indicator therapy response and improve prediction PCR early first treatment time point in NAC.
Abstract Objective To determine the characteristics of choriovascular anatomy, especially potential role arteriovenous perfusion imbalance in pathogenesis selective intrauterine growth restriction (sIUGR) using three‐dimensional computed tomography angiography (3D‐CTA). Method Computed placental tree from 15 twins with sIUGR and without were analyzed, inter‐twin vascular anastomoses compared between placentas these two groups. The parameters evaluated presence measures artery‐to‐artery...
As one of the earliest application for E-commerce, E-tailing has existed several years. This paper will discuss this topic in details. There are seven sections including introduction, state industry, benefits and barriers E-tailing, why failed, successful case analysis, Trends conclusion.
Objective To investigate the differences of risk factors and stroke menchanisms between young middle-aged patients with symptomatic cerebral artery atherosclerosis (sCAA). Methods The (18-44 years) (45-55 sCAA caused ischemic or transient attack admitted to hospital were enrolled consecutively. According distribution patterns acute infarcts on diffusion-weighted imaging, mechanisms identified, including artery-artery embolism (AAE), local branch occlusion (LBO), hemodynamic impairment...
Non-invasive glycogen quantification in vivo could provide crucial information on biological processes for storage disorder. Using dual-energy computed tomography (DECT), this study aimed to assess the viability of quantifying content vitro.A fast kilovolt-peak switching DECT was used scan a phantom containing 33 cylinders with different proportions and iodine mixture at varying doses. The virtual concentration (VGC) then measured using material composition images. Additionally, correlations...
Poster: ECR 2015 / C-2028 Evaluation of correlations among apparent diffusion coefficient and permeability parameters from dynamic contrast-enhanced MR in brain tumour parenchyma peritumoral area by: J. Zhao , P. Chu, J.-Y. Yang, Z. Y. B. Luo; Guangzhou/CN
Objective To explore the value of small surface coil combined with three-dimensional double-echo steady-state water excitation (3D-DESS-WE) sequence in displaying mandibular nerves and their branches. Methods The maxillofacial regions 52 volunteers were scanned unilaterally by a 3D-DESS-WE sequence. According to Gray's anatomy atlas, MPR CPR was done according anatomic position nerve branches, signal characteristics neighboring structures analyzed. The rate branches evaluated.The...
Objective To study the correlation between computed tomography (CT) features and clinical presentation management in isolated dissection of superior mesenteric artery (IDSMA). Methods We retrospectively analyzed records CT findings patients with IDSMA from 2012 to 2016. The relationship symptom therapeutic strategy these were investigated. In addition, data scans telephone interviews during follow-up reviewed as well. Results A total 64 evaluated, including 40 symptomatic 24...