A5031907069- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- DNA Repair Mechanisms
- Total Knee Arthroplasty Outcomes
- Venous Thromboembolism Diagnosis and Management
- Orthopaedic implants and arthroplasty
- Ion channel regulation and function
- Peripheral Neuropathies and Disorders
- Ion Channels and Receptors
- PI3K/AKT/mTOR signaling in cancer
- Hereditary Neurological Disorders
- Toxin Mechanisms and Immunotoxins
- PARP inhibition in cancer therapy
- Dermatology and Skin Diseases
- Orthopedic Infections and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Mitochondrial Function and Pathology
- Brain Metastases and Treatment
- RNA Interference and Gene Delivery
- Neuroblastoma Research and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Adenosine and Purinergic Signaling
- Cancer, Hypoxia, and Metabolism
- Immunotherapy and Immune Responses
- Tuberous Sclerosis Complex Research
Zhuhai People's Hospital
2020-2025
St. Jude Children's Research Hospital
2023-2025
Capital Normal University
2024-2025
Southwest University
2025
Zhuhai Institute of Advanced Technology
2025
Beijing Institute of Technology
2025
Xiangya Hospital Central South University
2014-2024
Central South University
2015-2024
State Grid Corporation of China (China)
2024
The University of Texas Southwestern Medical Center
2022-2023
Abstract Although both persistent itch and inflammation are commonly associated with allergic contact dermatitis (ACD), it is not known if they mediated by shared or distinct signaling pathways. Here we show that TRPA1 TRPV1 channels required for generating spontaneous scratching in a mouse model of ACD induced squaric acid dibutylester (SADBE), small molecule hapten, through directly promoting the excitability pruriceptors. but protect skin inflammation, as genetic ablation function...
Zinc is a transition metal that has long history of use as an anti-inflammatory agent. It also soothes pain sensations in number animal models. However, the effects and mechanisms zinc on chemotherapy-induced peripheral neuropathy remain unknown. Here we show locally injected markedly reduces neuropathic male female mice induced by paclitaxel, chemotherapy drug, TRPV1-dependent manner. Extracellularly applied inhibits function TRPV1 expressed HEK293 cells mouse DRG neurons, which requires...
Abnormal dendritic complexity is a shared feature of many neurodevelopmental disorders associated with neurological defects. Here, we found that the actin-crosslinking protein filamin A (FLNA) overexpressed in tuberous sclerosis complex (TSC) mice, PI3K-mTOR model disease abnormal complexity. Both under- and overexpression FLNA wild-type neurons led to more arbors vivo, suggesting an optimal level expression required for normal dendritogenesis. In Tsc1 null neurons, knocking down vivo...
Inhibiting filamin A has therapeutic effects in a model of tuberous sclerosis complex and subset focal cortical dysplasia.
Background: Although the diagnosis and treatment of glioblastoma (GBM) is significantly improved with recent progresses, there still a large heterogeneity in therapeutic effects overall survival. The aim this study to analyze gene expressions transcription factors (TFs) GBM so as discover new tumor markers. Methods: Differentially expressed TFs are identified by data mining using public databases. transcriptome profile downloaded from Cancer Genome Atlas (TCGA). nonnegative matrix...
Abstract Tremendous efforts have been made to explore biomarkers for classification and grading on gliomas. The goal of this study was identify more molecular features that are associated with clinical outcomes by comparing the genomic profiles primary recurrent gliomas determine potential recurrence leading factors significantly enriched in relapse tumors. Hybrid capture based next generation sequencing (NGS) analysis performed 64 17 glioma biopsies. Copy number variation (CNV) frequent...
This study aimed to explore whether serum combined with synovial interleukin-6 (IL-6) measurement can improve the accuracy of prosthetic joint infection (PJI) diagnosis, and establish cut-off values IL-6 in fluid detecting chronic PJI.Patients scheduled have a revision surgery for indications knee hip arthroplasties or aseptic loosening an implant were prospectively screened before being enrolled into this study. The Musculoskeletal Infection Society (MSIS) definition PJI was used...
Objective Tumor-treating fields (TTFields) are a new therapeutic modality for patients with glioblastoma (GBM). However, studies on survival outcomes of TTFields rarely reported in China. This study aimed to examine the clinical efficacy and safety therapy GBM Methods A total 93 newly diagnosed (ndGBM) recurrent (rGBM) were included our retrospectively. They divided into two groups based whether they used TTFields. Progression-free (PFS), overall (OS), toxicities assessed. Results Among...
Abnormal axonal connectivity and hyperactive mTOR complex 1 (mTORC1) are shared features of several neurological disorders. Hyperactive mTORC1 alters axon length polarity hippocampal neurons in vitro, but the impact on growth vivo mechanisms underlying those effects remain unclear. Using utero electroporation during corticogenesis, we show that increasing activity accelerates without multiple formation. This was prevented by counteracting signaling through p70S6Ks (S6K1/2) or eukaryotic...
Recent studies have suggested that adenosine generated by ecto-5′-nucleotidase (CD73) in the tumor microenvironment plays a major role promoting growth suppressing immune response and stimulating angiogenesis via A2A A2B receptors. However, has also been reported to inhibit acting A1 A3 Therefore aim of this study was clarify host CD73, which catalyzes extracellular hydrolysis AMP adenosine, on metastasis B16-F10 melanoma cells. CD73 alkaline phosphatase (AP) activity cells were measured...
Abstract The fragile X mental retardation protein (FMRP) is an mRNA-binding regulator of translation that associates with 4-6% brain transcripts and central to neurodevelopment. Autism risk genes’ are overrepresented among FMRP-binding mRNAs, FMRP loss-of-function mutations responsible for syndrome, the most common cause monogenetic autism. It thought FMRP-dependent translational repression governed by phosphorylation serine residue 499 (S499). However, recent evidence suggests S499 not...
BACKGROUND The objective of this study was to analyze the effects general anesthesia in cesarean section on umbilical cord blood gas values and intraoperative hemodynamics parturient women. MATERIAL AND METHODS A total 112 women who received were eventually randomized into 2 groups, GA (general anesthesia) group (n=56), SE (combined spinal epidural (n=56). values, postpartum Apgar score, loss, mean arterial pressure, heart rate, operative time, time intervals from delivery skin incision...
H3K27M-mutant diffuse midline glioma (DMG) is a rare and aggressive central nervous system tumor. The biological behavior, clinicopathological characteristics, prognostic factors of DMG have not yet been completely uncovered, especially in adult patients. This study aims to investigate the characteristics identify pediatric patients, respectively.
Recent studies have demonstrated that a subset of long noncoding RNAs (lncRNAs) produce functional polypeptides and proteins. In this study, we discovered 132 amino acid protein in human breast cancer cells named XCP (X-linked Cancer-associated Polypeptide), which is encoded by lncRNA1456 (a.k.a. RHOXF1P3), transcript previously thought to be noncoding. pancreas- testis-specific RNA whose gene located on chromosome X. We found the expression are highly upregulated luminal A, B, HER2...
Mitochondrial fission and fusion are tightly regulated to specify mitochondrial abundance, localization, arrangement during cell division as well in the diverse differentiated types physiological states. However, regulatory pathways for such dynamics less explored than components. Here we report a large-scale screen genes that regulate fission. defects cause characteristic uneven fluorescent pattern embryos carrying stress reporter genes. Using this activation, performed RNAi screens...
Serum antinuclear antibodies (ANAs) facilitate the diagnosis and evaluation of patients with many systemic autoimmune conditions. However, there are no systematic reports concerning differences in Guillain-Barré syndrome (GBS) chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Therefore, we assessed serum ANAs GBS CIDP control subjects a Chinese cohort. A retrospective enrollment 417 was conducted for this study, consisting 158 clinically confirmed patients, 115 144 non-GBS...
Osteoarthritis (OA) is a major public health concern for which reliable non-invasive treatment option has yet to be developed. In the present study, we investigated effects of saxagliptin, novel dipeptidyl peptidase IV (DPP-4) inhibitor, on several important aspects pathophysiology OA using primary human chondrocytes. The results real-time PCR and ELISA analyses show that saxagliptin significantly decreased mRNA protein expression three key cartilage degrading enzymes: matrix...
To uncover the potential effect of metformin on proliferation and apoptosis thyroid cancer TPC-1 cell line, underlying mechanism.Viability, LRP2 level in cells treated with different doses for time points were determined. Besides, protein levels p-JNK1 c-Jun N-terminal kinases (JNK) metformin-treated detected by Western blot. Regulatory effects JNK pathway viability assessed.Viability gradually decreased treatment increased either 24 h or 48 h. The apoptotic rate was...
Abstract Background Besides the hallmark of H3K27M mutation, aberrant amplifications receptor tyrosine kinases (RTKs) are commonly observed in diffuse midline glioma (DMG), a highly malignant brain tumor with dismal prognosis. Here, we intended to evaluate efficacy and safety multitarget RTK inhibitor anlotinib patients H3K27M‐DMG. Methods A total 40 newly diagnosed H3K27M‐DMG including 15 25 without treatment were retrospectively enrolled this cohort. Progression‐free survival (PFS),...
Avulsion fractures of the tibial insertion posterior cruciate ligament (PCL) have always been regarded as rare injuries. The attachment PCL is located in an area, which difficult to access. To verify effects anterior arthroscopic fixation avulsion fractures. 18 patients with fracture were included. inclusion criteria were: (1) fragment size was greater than 20 mm; (2) surgery acute phase (<3 weeks). intervention Outcome variables included laxity assessment KT2000 arthrometer, sag sign,...
Aim: To identify spinocerebellar ataxia Type 3 (SCA3)-related exosomal biomarkers and the underlying mechanisms. Materials & methods: Exosomal RNAs from plasma cerebrospinal fluid (CSF) were extracted 24 SCA3 patients 22 controls, respectively. Small RNA sequencing quantitative PCR verification performed. Gene ontology annotation Kyoto Encyclopedia of Genes Genomes pathway analyses results carried out. Results: One novel miRNA is notably downregulated in plasma-derived exosomes, while...