A5103238733- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Glioma Diagnosis and Treatment
- HIV/AIDS Research and Interventions
- Reproductive tract infections research
- 3D Printing in Biomedical Research
- Nanoparticle-Based Drug Delivery
- HIV Research and Treatment
- Alcohol Consumption and Health Effects
- Endometrial and Cervical Cancer Treatments
- Autophagy in Disease and Therapy
- Reproductive System and Pregnancy
- Cervical Cancer and HPV Research
- Cancer, Hypoxia, and Metabolism
- Polymer Foaming and Composites
- Nanoplatforms for cancer theranostics
- Additive Manufacturing and 3D Printing Technologies
- Ovarian cancer diagnosis and treatment
- Lipid Membrane Structure and Behavior
- Advancements in Transdermal Drug Delivery
- Trace Elements in Health
- Injection Molding Process and Properties
- Nanofabrication and Lithography Techniques
- Phytoestrogen effects and research
- Stress Responses and Cortisol
University of Ulster
2005-2024
University of Birmingham
2015-2024
Deakin University
2021-2023
University of Nigeria
2022
RMIT University
2021
Belfast City Hospital
2016
Belfast Health and Social Care Trust
2016
University of Wolverhampton
2012-2015
Queen's University Belfast
2008-2015
Curtin University
2011-2012
Hydrogen is emerging as an alternative clean fuel; however, its dependency on freshwater will be a threat to sustainable environment. Seawater, unlimited source, can alternative, but salt-rich nature causes corrosion and introduces several competing reactions, hindering use. To overcome these, unique catalyst composed of porous sheets nitrogen-doped NiMo3 P (N-NiMo3 P) having sheet size microns designed. The presence large homogenous pores in the basal plane these makes them catalytically...
Material choice is a fundamental consideration when it comes to designing solid dosage form. The matrix material will ultimately determine the rate of drug release since physical properties (solubility, viscosity, and more) control both fluid ingress disintegration bulk (powder flow, concentration, should also be considered these influence ability successfully manufactured. Furthermore, there limited number approved materials for production forms. present study details complications that can...
Disulfiram (DS), an anti-alcoholism drug, shows very strong cytotoxicity in many cancer types. However its clinical application treatment is limited by the short half-life bloodstream. In this study, we developed a poly lactic-co-glycolic acid (PLGA)-encapsulated DS protecting from degradation The newly DS-PLGA was characterized. has satisfactory encapsulation efficiency, drug-loading content and controlled release rate vitro. PLGA extended of shorter than 2minutes to 7hours serum....
The anticancer activity of disulfiram (DS) is copper(ii) (Cu)-dependent. This study investigated the mechanisms DS/Cu using in vitro cytotoxicity and metabolic kinetic analysis. Our indicates that targets cancer cells by combination two types actions: (1) instant killing executed reaction generated reactive oxygen species; (2) delayed introduced end product, DDC-Cu. Nanoencapsulation DS might shed light on repositioning into treatment.
The quality of decision and assessment risk are key determinants successful sport performance. Athletes differ fundamentally in their decision-making ability according to athletic expertise level. Moreover, given the influence emotions on decision-making, it is likely that a trait reflecting emotional functioning, intelligence, may also decision-making. Therefore, aim this research was investigate respective contribution intelligence non-athletic In total, 269 participants aged between 18 26...
Background: The Box–Behnken design of experiments (BBD) is a statistical modelling technique that allows the determination significant factors in developing nanoparticles (NPs) using limited number runs. It also prediction best levels variables to obtain desired characteristics (size, charge, and encapsulation efficiency) NPs. aim this study was examine effect independent (amount polymer drug, surfactant concentration) their interaction on irinotecan hydrochloride (IRH)-loaded...
The treatment for Glioblastoma is limited due to the presence of blood brain barrier, which restricts entry chemotherapeutic drugs into brain. Local delivery tumor resection margin has potential improve efficacy chemotherapy. We developed a safe and clinically translatable irinotecan implant local increase its while minimizing systemic side effects. Irinotecan-loaded implants were manufactured using hot melt extrusion, gamma sterilized at 25 kGy, characterized their content, release, drug...
Disulfiram (DS), an antialcoholism medicine, demonstrated strong anticancer activity in the laboratory but did not show promising results clinical trials. The of DS is copper dependent. reaction and generates reactive oxygen species (ROS). After oral administration clinic, enriched quickly metabolised liver. associated change chemical structure may make metabolites lose its copper-chelating ability disable their activity. still largely unknown. Elucidation relationship between key will...
Background: High-grade gliomas (HGGs) are highly malignant tumors with a poor survival rate. The inability of free drugs to cross the blood–brain barrier and their off-target accumulation result in dose-limiting side effects. This study aimed at enhancing encapsulation efficiency (EE) irinotecan hydrochloride trihydrate (IRH) within polycaprolactone (PCL) nanoparticles optimized size charge. Materials Methods: IRH-loaded PCL were formulated using either single emulsion (O/W, W/O O/O) or...