A5004996281- Lung Cancer Treatments and Mutations
- Prostate Cancer Treatment and Research
- Molecular Biology Techniques and Applications
- Lung Cancer Diagnosis and Treatment
- Prostate Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Treatments and Studies
- Single-cell and spatial transcriptomics
- Neuroendocrine Tumor Research Advances
- Pancreatic and Hepatic Oncology Research
- Cancer-related molecular mechanisms research
- Hepatocellular Carcinoma Treatment and Prognosis
- Neuroblastoma Research and Treatments
- Bioinformatics and Genomic Networks
- Gene expression and cancer classification
- Colorectal and Anal Carcinomas
- Salivary Gland Tumors Diagnosis and Treatment
- Contact Dermatitis and Allergies
- Liver Disease Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Lung Cancer Research Studies
- Optical Imaging and Spectroscopy Techniques
- Infrared Thermography in Medicine
- Photoacoustic and Ultrasonic Imaging
University of Oxford
2016-2025
Oxford University Hospitals NHS Trust
2019-2024
Churchill Hospital
2016-2024
Guy's and St Thomas' NHS Foundation Trust
2019
Great Western Hospital
2017
St Thomas' Hospital
2015
Royal Surrey County Hospital
2012
Abstract Pancreatic ductal adenocarcinoma has a dismal prognosis. A comprehensive analysis of single-cell multi-omic data from matched tumour-infiltrated CD45+ cells and peripheral blood in 12 patients, two published datasets, reveals complex immune infiltrate. Patients have either myeloid-enriched or adaptive-enriched tumour microenvironment. Adaptive cell-enriched is intrinsically linked with highly distinct B T cell clonal selection, diversification, differentiation. Using TCR data, we...
Metastatic breast cancer (mBC) patients with DPYD genetic variants linked to loss of dihydropyrimidine dehydrogenase (DPD) activity are at risk severe capecitabine-associated toxicities. However, prospective genotyping has not yet been implemented in routine clinical practice. Following a previous internal review which two underwent lengthy hospitalisations whilst receiving capecitabine, and were subsequently found be DPD deficient, we initiated prior starting capecitabine. This study...
TP53, the
Abstract Aim There is significant international variation in the use of neoadjuvant radiation prior to total mesorectal excision. The MERCURY group advocate selective chemoradiotherapy (CRT). We have performed a retrospective, single‐centre study patients treated with CRT, where only circumferential resection margin threatened, aim identifying whether more approach CRT provides acceptable local relapse rates (LRRs). Method All consecutive who underwent radical surgery for rectal...
Abstract Background It is important to identify molecular features that improve prostate cancer (PCa) risk stratification before radical treatment with curative intent. Molecular analysis of historical diagnostic formalin‐fixed paraffin‐embedded (FFPE) biopsies from cohorts post‐radiotherapy (RT) long‐term clinical follow‐up has been limited. Utilizing parallel sequencing modalities, we performed a proof‐of‐principle FFPE biopsies. We compared patients (i) stable PCa (sPCa) postprimary or...
Abstract Pancreatic ductal adenocarcinoma (PDAC) has an extremely poor prognosis. Understanding the multiple mechanisms by which tumour evades immune control, and how these may be disrupted is critical to developing targeted immunotherapies. Previous studies have shown that higher lymphocyte infiltration associated with better survival, here we investigated what mediates differences. We performed a comprehensive analysis of PDAC-associated cells using single cell multi-omics coupled...
Abstract Background It is important to investigate, diagnose and commence treatment for locally advanced metastatic prostate cancer quickly optimise outcomes. Since the introduction of national 2-week wait 31/62-day targets in United Kingdom investigation suspected over 2 decades ago, clinical pathway has become increasingly complex. This may lead some patients with most clinically significant disease having rapidity their diagnosis commencement compromised by resource use diagnosing less...
A 31-year-old man presented to dermatology with a 4 day history of an intensely itchy, linear, vesicular rash affecting the palms both hands, on background recent exposure patient scabies. The had childhood eczema and asthma but no exacerbations in adulthood. Examination microscopy revealed …
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Purpose: It is important to identify molecular features that improve prostate cancer (PCa) risk stratification before radical treatment with curative intent. Molecular analysis of historical diagnostic formalin-fixed paraffin-embedded (FFPE) biopsies from cohorts post-radiotherapy (RT) long-term clinical follow-up has been limited. Utilizing parallel sequencing modalities, we performed a proof-of-principle FFPE biopsies. We compared patients i) stable PCa post-primary or salvage RT (sPCa),...
in the Tocilizumab and Abatacept (100% for both) cohorts compared to Rituximab (71%) Etanercept (48%).This study helps place tocilizumab as a key drug biologic monotherapy.An ongoing multicentre will provide greater information.
A bstract The gene encoding tumor protein p53 ( TP53 ) is the most frequently mutated in human cancer. Mutations both coding and non-coding regions of can disrupt regulatory function transcription factor, but functional impact different somatic mutations on global regulon complex poorly understood. To address this, we first proceed with a machine learning (ML) approach, then propose an integrated computational network modelling approach that reconstructs signalling networks using...