A5100415168- Cancer Immunotherapy and Biomarkers
- Religion, Spirituality, and Psychology
- EFL/ESL Teaching and Learning
- Ferroptosis and cancer prognosis
- Student Assessment and Feedback
- Health and Wellbeing Research
- Neurological disorders and treatments
- Multiple Myeloma Research and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Medical Research and Treatments
- Lymphoma Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Forensic Fingerprint Detection Methods
- Tuberculosis Research and Epidemiology
- Workplace Spirituality and Leadership
- Pediatric health and respiratory diseases
- Higher Education Learning Practices
- Tryptophan and brain disorders
- Alzheimer's disease research and treatments
- Cancer-related molecular mechanisms research
- Nuclear Receptors and Signaling
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Education and Work Dynamics
- Plant-derived Lignans Synthesis and Bioactivity
- Higher Education and Teaching Methods
Longgang Central Hospital
2025
Kunming Medical University
2013-2024
Chengdu Medical College
2017-2024
Dalian University of Technology
2024
First Affiliated Hospital of Kunming Medical University
2015-2024
State Key Laboratory of Oncology in South China
2022-2023
Sun Yat-sen University
2018-2023
Sun Yat-sen University Cancer Center
2018-2023
Nanyang Technological University
2018-2023
The Fifth People’s Hospital of Suzhou
2023
Abstract Introduction Traumatic brain injury (TBI) is associated with a profound immunological dysfunction manifested by severe shift from T-helper type 1 (Th1) to 2 (Th2) response. This predisposes patients infections, sepsis, and adverse outcomes. Probiotic bacteria have been shown balance the Th1/Th2 cytokines in allergic murine models patients. For present study, we hypothesized that enteral administration of probiotics would adjust imbalance improve clinical outcomes TBI Methods We...
Background: We aimed to investigate the correlations between ACE2 polymorphisms and type 2 diabetes mellitus (T2DM) combined with cerebral stroke (CS).Methods: A total of 346 patients treated or hospitalized in our hospital were enrolled, including 181 cases without cerebrovascular complications (T2DM group) 165 CS + group); 284 healthy individuals selected as control group.PCR-RFLP ELISA used analyze G8790A serum levels, respectively.Results: Significant differences observed genotype/allele...
This study aims to figure out the mechanism of astragaloside IV (AS-IV) in protection podocyte apoptosis diabetic nephropathy (DN) rats.Streptozotocin (STZ) was used induce diabetes rats, and rats were treated with 5 mg/kg/d AS-IV for 12 weeks. Albuminuria level, relative TUG1 TRAF5 levels, cleaved-caspase-3 protein levels examined by ELISA, quantitative reverse transcription (qRT)-PCR, Western blot analyses, respectively. The interaction between confirmed RNA pull-down precipitation. TUNEL...
We aimed to assess the prognostic value of pretreatment inflammatory and nutritional parameters for predicting overall survival (OS) in patients with newly diagnosed multiple myeloma (NDMM), build a new scoring system using most important variables.We retrospectively analyzed baseline clinical laboratory data NDMM, who were randomly grouped into training validation cohorts at ratio 8:2. The Inflammatory Nutritional Score (INS) was developed based on least absolute shrinkage selection...
This study aimed to investigate the status quo of nurses' spiritual care competency and their relationship with perceived professional benefit.Spiritual has always been considered a vitally important part holistic nursing. Understanding nurses during COVID-19 pandemic can help nursing managers understand weak links in practice improve quality service. As positive emotional experience cognitive evaluation profession, benefit serve adjust work pressure, relieve job burnout promote an...
Schisandrin, an active component extracted from Schisandra chinensis (Turcz.)Baill has been reported to alleviate the cognitive impairment in neurodegenerative disorder like Alzheimer's disease (AD).However, mechanism by which schisandrin regulates decline is still unclear.In our study, intracerebroventricular injection of streptozotocin (STZ) was employed establish AD model male Wistar rats, and indicated dose further administered.The Morris water maze test performed evaluate ability...
Thioredoxin-interacting protein (TXNIP) plays a pivotal role in regulation of blood glucose homeostasis and is an emerging therapeutic target diabetes its complications. Celastrol, pentacyclic triterpene extracted from the roots Tripterygium wilfordii Hook F, can reduce insulin resistance improve diabetic complications.This study aimed to untangle mechanism celastrol ameliorating type 2 (T2DM) evaluate potential benefits as anti-diabetic agent.db/db mice was used hypoglycemic effect vivo;...
The complex burst characteristic parameters of SCB were subjected to dimensionality reduction using principal component analysis (PCA), enabling accurate evaluation the output performance SCB. accuracy and reliability PCA method also validated. A 100 μF tantalum capacitor was utilized excite SCB, while a digital oscilloscope recorded explosion. experimental results demonstrate that critical time decreases with rising voltage, energy first then increases voltage. total all decrease increase...
Aims and objectives. To explore: the selection criteria for first responder nurses during disaster; scope of practice disaster relief nurses; appropriate nurse – medical practitioner ratio at site. Background. Nurses are key members response teams. A scarcity literature exists relating to attending disasters, their qualifications, experience, staffing ratios. Design. Qualitative quantitative data were collected via survey using self‐developed questionnaires. Participants 95 workers, who...
Background: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease characterized by insulin resistance and hyperglycemia. This study examined the effect elucidated mechanism of improvement hyperglycemia co-crystal rosiglitazone with berberine (RB) in high-sugar high-fat diet (HSHFD)-induced diabetic KKAy mice. Methods: Diabetic mice were randomly divided into seven groups: model control group (DM control) treated 3% sodium carboxymethyl cellulose; RB groups, administered daily 0.7...
Background: The tumor-associated endothelial cell (TAE) component plays a vital role in tumor immunity. However, systematic endothelial-related gene assessment models for predicting cancer immunotherapy (CIT) responses and survival across human cancers have not been explored. Herein, we investigated TAE risk model to predict CIT patient pan-cancer analysis. Methods: We analyzed publicly available datasets of samples with expression clinical information, including gastric cancer, metastatic...
Urination disorders are common in Parkinson's disease (PD) and respond poorly to medication. This study aimed analyze the risk factors for urination PD. Ninety-one patients with PD (aged 34-83 years old) were recruited. Patients assessed Unified Rating Scale (UPDRS), Hoehn Yahr stage, Pittsburgh Sleep Quality Index (PSQI), Hamilton Depression (HAMD), Anxiety (HAMA). Micturition number was recorded, Type B ultrasound used evaluate residual urine. Statistics performed using binary logistic...
We sought to evaluate the impact of biventricular (BiV) pacing with ventricular fusion by intrinsic atrioventricular nodal (AVN) conduction (BiV + pacing) on clinical outcomes in patients chronic heart failure (CHF) receiving cardiac resynchronization therapy (CRT).A total 44 were randomized receive either BiV or for one month. Echocardiographic optimization was performed mode, while mode achieved titrating AV delay under electrocardiography (ECG) monitoring. Symptoms, quality life, ECG,...
AIM:To study the protective effect of eukaryotic expression plasmid encoding augmenter liver regeneration (ALR) on acute hepatic injury and failure in rats. METHODS:The PCR-amplified ALR gene was recombined with pcDNA3 plasmid, used to treat rats injury.The induced by intraperitoneal injection 2 mL/kg 50% carbon tetrachloride (CCl 4 ) were randomly divided into saline control group recombinant pcDNA3-ALR treatment groups.Recombinant DNA (50 or 200 g/kg) injected intravenously,...
Functional gene expression signatures (FGES) from pretreatment biopsy samples have been used to predict the responses of metastatic melanoma immune checkpoint blockade (ICB) therapies. However, there are no predictive FGE patients receiving treatment. Here, using Elastic Net Regression (ENLR) algorithm, we analyzed transcriptomic and matching clinical data a dataset with treated ICB therapies produced an signature for (FGES-PRE) on-treatment (FGES-ON). Both FGES-PRE FGES-ON validated in...