A5088744349- Anesthesia and Pain Management
- Nausea and vomiting management
- Anesthesia and Sedative Agents
- Signaling Pathways in Disease
- PARP inhibition in cancer therapy
- Pain Mechanisms and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Cell death mechanisms and regulation
- Sirtuins and Resveratrol in Medicine
- Anesthesia and Neurotoxicity Research
Zhejiang University
2024
Changhai Hospital
2024
Second Military Medical University
2024
Shaanxi Provincial People's Hospital
2020
Shanxi Medical University
2020
Zhejiang Chinese Medical University
2019
Objectives Opioid-free anaesthesia (OFA) has emerged as a promising approach for mitigating the adverse effects associated with opioids. The objective of this study was to evaluate impact OFA on postoperative nausea and vomiting (PONV) following video-assisted thoracic surgery. Design Single-centre randomised controlled trial. Setting Tertiary hospital in Shanghai, China. Participants Patients undergoing surgery were recruited from September 2021 June 2022. Intervention randomly allocated or...
Thoracotomy is frequently accompanied with moderate-to-severe postoperative pain, and excellent pain management important for early rehabilitation. The purpose of this study to investigate the effects dexmedetomidine combined ropivacaine epidural analgesia after thoracotomy.One hundred thirty patients undergoing elective lung lobectomy were enrolled in double-blind randomly divided into two groups. Group A received 0.5 µg/mL plus 0.1% analgesia, group B (control group) sufentanil analgesia....
Lidocaine, a typical local anesthetic, has been shown to directly induce neurotoxicity in clinical settings. Dexmedetomidine (DEX) is an alpha-2-adrenoreceptor agonist that used as anxiolytic, sedative, and analgesic agent which recently found protect against lidocaine-induced neurotoxicity. Nicotinamide adenine dinucleotide-dependent deacetylase sirtuin-1 (SIRT1)/forkhead box O3 (FOXO3a) signaling critical for maintaining neuronal function regulation of the apoptotic pathway. In present...