A5078511427- Clostridium difficile and Clostridium perfringens research
- HIV/AIDS drug development and treatment
- Microscopic Colitis
- HIV Research and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Mycobacterium research and diagnosis
- Nosocomial Infections in ICU
- Viral gastroenteritis research and epidemiology
- Mosquito-borne diseases and control
- Williams Syndrome Research
- Viral Infections and Vectors
- Antimicrobial Resistance in Staphylococcus
- Streptococcal Infections and Treatments
- Neutropenia and Cancer Infections
- Bacterial Identification and Susceptibility Testing
- Infective Endocarditis Diagnosis and Management
- Infectious Diseases and Tuberculosis
- Adipose Tissue and Metabolism
- Tuberculosis Research and Epidemiology
- Gestational Diabetes Research and Management
- Congenital heart defects research
- Hepatitis C virus research
- S100 Proteins and Annexins
- Neurogenetic and Muscular Disorders Research
- Intracerebral and Subarachnoid Hemorrhage Research
Michigan State University
2018-2025
Central Michigan University
2024-2025
Northwell Health
2024
Corewell Health
2023-2024
The University of Texas MD Anderson Cancer Center
2024
Corewell Health Blodgett Hospital
2019-2023
Spectrum Health
2019-2023
Lakeland Health
2017-2023
University of Minnesota Medical Center
2023
University of Minnesota
2023
Pyrimidinol carboxylic acids were designed as inhibitors of HIV-1 RNase H function. These molecules can coordinate to two divalent metal ions in the active site. Inhibition enzymatic activity was measured a biochemical assay, but no antiviral effect observed. Binding demonstrated via solid state structure isolated p15-Ec domain RT showing inhibitor and Mn(II) bound
Understanding the evolutionary strategies of SARS-CoV-2 omicron variant is crucial for comprehending COVID-19 pandemic and preventing future coronavirus pandemics. In this study, we determined crystal structures receptor-binding domains (RBDs) from currently circulating subvariants XBB.1 XBB.1.5 (also emerging XBB.1.9.1), each complexed with human ACE2. We studied how individual RBD residues evolved structurally in subvariants, specifically they adapted to Our findings revealed that 493 496,...
Acute spinal cord injury (SCI) is a devastating condition with many consequences and no known effective treatment. Although it quite easy to diagnose traumatic SCI, the assessment of severity projection disease progression or recovery are often challenging, as consensus biomarkers have been clearly identified. Here rats were subjected experimental moderate severe thoracic SCI. At 24h 7d postinjury, segment caudal center versus sham samples was harvested differential proteomic analysis....
There has been a recent proliferation of studies exploring awareness in people with dementia and, as is the case similar other clinical areas, results are generally mixed and inconsistent. One reasons underlying variability study relates to complexities around concept itself. Two sources conceptual problems explored. First, meaning examined within literature, various conceptualizations identified which could be traced three broad frameworks related terms conceived. Differences between...
Semicarbazide-sensitive amine oxidase (SSAO) is located on outer surfaces of adipocytes and endothelial vascular smooth muscle cells. This enzyme catalyzes deamination methylamine aminoacetone, leading to production toxic formaldehyde methylglyoxal, respectively, as well hydrogen peroxide ammonium. Several lines evidence suggest that increased SSAO activity related chronic inflammation disorders diabetic complications. We found a highly potent selective inhibitor,...
Objective. To describe characteristics of Clostridium difficile infection (CDI) and markers severe CDI among patients with hematologic malignancies. Design. Case-control study. Setting. Tertiary care teaching hospital. Patients Methods. Inpatients malignancies were age time matched 2 control inpatients without Chart reviews performed, C. isolates strain typed. Results. Case ( n = 41) 82) different in respect to receipt immunosuppressive agents within months (92.7% vs 25.6%; P < .0001);...
Bruton tyrosine kinase inhibitors (BTKi) have transformed the treatment of B-cell malignancies, but intolerance has often led to their discontinuation. The phase 1/2 BRUIN study evaluated pirtobrutinib, a highly selective non-covalent (reversible) BTKi, in patients with R/R malignancies (NCT03740529). Pirtobrutinib was investigated 127 at least one prior BTKi therapy absence progressive disease. most common adverse event (AE) leading discontinuation cardiac disorders (n=40, 31.5%),...
Assess the efficacy of staged interventions aimed to reduce inappropriate Clostridioides difficile testing and hospital-onset C. infection (HO-CDI) rates. Interrupted time series. Community-based. National Healthcare Safety Network (NHSN) metrics from January 2019 November 2022 were analyzed after three at a community-based healthcare system. Interventions included: (1) an electronic medical record (EMR) based hard stop requiring confirming ≥3 loose or liquid stools over 24 h, (2) infectious...
Williams-Beuren syndrome (WBS) results from a deletion of 7q11.23 in 90-95% all clinically typical cases. Clinical manifestation can be variable and therefore, size, inherited elastin (ELN) LIM kinase 1 (LIMK1) alleles, gender, parental origin have been investigated for associations with clinical outcome. In an analysis 85 confirmed cases, no statistically significant were found after Bonferroni's correction multiple pairwise comparisons. Furthermore, the present data do not support presence...
Abstract Background Eastern equine encephalitis virus is a mosquito-borne alphavirus responsible for unpredictable outbreaks of severe neurologic disease in animals and humans. While most human infections are asymptomatic or clinically nonspecific, minority patients develops encephalitic disease, devastating illness with mortality rate ≥30%. No treatments known to be effective. infection rare the United States, an annual average nationwide incidence 7 cases between 2009 2018. However, 2019,...
Abstract Measles virus infection of B‐cells results in marked alterations proliferation and immunoglobulin production. Very little is known about the changes gene expression, if any, during acute measles infection. To elucidate cellular genes that are induced infection, we carried out a subtraction technique, representational differential analysis. The mitochondrial protein, manganese superoxide dismutase (MnSOD), was upregulated Although virus‐infected did not secrete MnSOD into...
Empiric antibiotics are often required in hospitalized patients with serious infections who may be septic and at risk for drug resistant organisms. The purpose of this study was to evaluate the observed incidence acute kidney injury (AKI) a sample adult receiving either piperacillin-tazobactam vancomycin or meropenemvancomycin least 72 hours.
We report a case of healthy 56-year-old male who presented with chronic swelling and erythema in his right hand. He had prior chemical exposure several years ago subsequent to freshwater, fish tank, soil. Laboratory data showed slightly elevated CRP. An MRI was consistent suggestive flexor tenosynovitis. underwent surgical debridement diagnosed Mycobacterium kansasii . treated clarithromycin, rifampin, isoniazid, but susceptibility testing revealed resistance isoniazid. Isoniazid switched...
In 2009, a major study by the World Health Organization (WHO) in conjunction with Harvard School of Public was published The New England Journal Medicine. This demonstrated significant improvement surgical complications and mortality implementation simple checklist (Table) used preoperatively, perioperatively, postoperatively.1 prospective observational carried out 8 hospitals around globe compared outcomes before (3733 consecutive patients) after (3955 patients). All patients underwent...
Streptococcus canis is an uncommon human pathogen, but documented infections have been mostly associated with exposure to dogs. There are only five cases of endocarditis secondary streptococcus canis, all except one documenting a canine. We present 74-year-old male history Type 2 diabetes mellitus, CKD 3, moderate aortic stenosis and remote agent orange, who was found native valve without dog. To the best our knowledge this case first linked feline exposure.
Objective: The objective of this study was to review the impact an automatic email notification infectious disease consultants.Design: Cases were identified from a community hospital system microbiology database by at least one positive blood culture. Records reviewed both before (2013 and 2014) after (2015 2016) implementation automated (intervention). Prior policy, consultation with (ID) specialist discretion primary team.Results: There no significant differences in 30-day mortality...
Williams-Beuren syndrome (WBS) results from a deletion of 7q11.23 in 90–95% all clinically typical cases. Clinical manifestation can be variable and therefore, size, inherited elastin (ELN) LIM kinase 1 (LIMK1) alleles, gender, parental origin have been investigated for associations with clinical outcome. In an analysis 85 confirmed cases, no statistically significant were found after Bonferroni's correction multiple pairwise comparisons. Furthermore, the present data do not support presence...
Abstract Background BRII-732, a prodrug of islatravir (ISL), is potent HIV-1 nucleotide reverse transcriptase translocation inhibitor. Following oral absorption, BRII-732 rapidly converted to ISL, which metabolized intracellularly the active metabolite, ISL triphosphate (ISL-TP). Single doses as low 0.5 mg significantly suppressed RNA by more than 1.0 log at day 7 in treatment-naive adults with infection. Current development work designed provide optimal drug exposure enable once weekly (QW)...