A5079423992- Amoebic Infections and Treatments
- Tryptophan and brain disorders
- Circadian rhythm and melatonin
- Neonatal Health and Biochemistry
- Child Nutrition and Water Access
- Research on Leishmaniasis Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Gut microbiota and health
- Biochemical and Molecular Research
- Trypanosoma species research and implications
- Stress Responses and Cortisol
- Anesthesia and Neurotoxicity Research
- Mosquito-borne diseases and control
- Diet and metabolism studies
- Heme Oxygenase-1 and Carbon Monoxide
- Vibrio bacteria research studies
- Bone and Dental Protein Studies
- Parasitic Infections and Diagnostics
- Superconductivity in MgB2 and Alloys
- Bipolar Disorder and Treatment
- Treatment of Major Depression
- Obstructive Sleep Apnea Research
- Neurogenesis and neuroplasticity mechanisms
- Viral Infections and Vectors
- Dietary Effects on Health
Instituto Nacional de Cardiología
2023-2025
Instituto Nacional de Psiquiatría
2021-2024
Instituto Politécnico Nacional
2017-2020
Center for Research and Advanced Studies of the National Polytechnic Institute
2017-2019
Melatonin (MEL) is a pleiotropic indolamine that reaches multiple intracellular targets. Among these, MEL binds to calmodulin (CaM) with high affinity. In presence of Ca2+, CaM CaM-dependent kinase II (CaMKII). The Ca2+-CaM/CaMKII pathway regulates myriad brain functions in different cellular compartments. Evidence showing the regulation this by scarce. Thus, our main objective was study interaction and its effects on CaMKII activity two microenvironments (aqueous lipidic) naturally...
Introduction: Marfan syndrome (MFS) is an autosomal dominant genetic disorder, caused by a mutation in the FBN-1 gene, affecting cardiovascular, musculoskeletal, ocular, and central nervous systems. Cardiovascular abnormalities associated with MFS lead to different pathological conditions, such as cardiac arrhythmias, coronary artery disease, aortic dilatation. The latter are primary causes of mortality patients. To date, role altered oral microbiota (OM) unknown, so aim our study was...
Major depressive disorder is a disabling disease with the number of affected individuals increasing each year. Current antidepressant treatments take between three to six weeks be effective forty percent patients being resistant treatment, making it necessary search for new treatments. Ketamine, phencyclidine hydrochloride derivative, given intravenously, induces rapid effect in humans. In mice, causes increased neurogenesis and antidepressant-like effects. However, also produces...
The state of Chiapas has held the first place extreme poverty in Mexico. majority Chiapas' municipalities are inhabited by marginalized, indigenous populations, who usually present diarrhea unknown etiology. We evaluated nutritional status, intestinal parasites, and common bacterial pathogens, including DEC (diarrheagenic Escherichia coli) strains, 178 children under five years age with a high (rural) moderate (urban) degree marginalization.Z-scores for anthropometric indexes from were...
Melatonin (MEL), an indolamine with diverse functions in the brain, has been shown to produce antidepressant-like effects, presumably through stimulating neurogenesis. We recently showed that combination of MEL ketamine (KET), NMDA receptor antagonist, robust effects mice, at doses that, by themselves, are non-effective and have no adverse effects. Here, we show KET/MEL increases neurogenesis a clone derived from human olfactory neuronal precursors, translational pre-clinical model for CNS....
Background:The state of Chiapas has held the first place extreme poverty in Mexico.The majority Chiapas' municipalities are inhabited by marginalized, indigenous populations, who usually present diarrhea unknown etiology.We evaluated nutritional status, intestinal parasites, and common bacterial pathogens, including DEC (diarrheagenic Escherichia coli) strains, 178 children under five years age with a high (rural) moderate (urban) degree marginalization.Methods: Z-scores for anthropometric...
The abundant number of kinases that Entamoeba histolytica possesses allows us to assume the regulation cellular functions by phosphorylation-dephosphorylation processes is very important. However, responsible for phosphorylation in spp. vary structure their domains and, therefore, could be unusual biological characteristics this parasite. In higher eukaryotes, Src share conserved structural and are important actin cytoskeleton. both invadens, major kinase homologue eukaryotes lacks SH3 SH2...
Abstract Rab proteins are present in all eukaryotic lineages and regulate vesicular trafficking. Entamoeba histolytica has approximately 100 genes encoding proteins, among which 16 have homology with human proteins. Human Rab21 participates integrin recycling, thus amoebic was believed to the mobilization of Eh β1FNR (integrin‐like fibronectin receptor related β1). We analyzed distribution using a polyclonal antibody produced specific peptide against protein, confocal microscopy probes for...
Recently, we published that the monoclonal antibody (D12 mAb) recognizes gp63 of L. mexicana, it is responsible for COX activity. This D12 mAb exhibited cross-reactivity with Trypanosoma cruzi, Entamoeba histolytica, Acanthamoeba castellanii, and Naegleria fowleri. activity assays performed in these parasites suggested potential presence such enzymatic In our investigation, confirmed wild-type recombinant exhibits COX-like activity, contrast to a mutated variant. Consequently, objective was...
Recently, we published that the monoclonal antibody (D12 mAb) recognizes gp63 of L. mexicana, and it is responsible for COX activity. This D12 mAb exhibited cross-reactivity with Trypanosoma cruzi, Entamoeba histolytica, Acanthamoeba castellanii, Naegleria fowleri. activity assays performed in these parasites suggested potential presence such enzymatic In our investigation, confirmed wild-type recombinant exhibits COX-like activity, contrast to a mutated variant. Consequently, objective was...
<b>Abstract ID 21584</b> <b>Poster Board 473</b> Melatonin (MEL; <i>N</i>-acetyl-5-hydroxytryptamine) and ketamine (KET; 2-(2-chlorophenyl)-2-(methylamino) cyclohexan-1-one) elicit antidepressant-like effects in mice increases neurogenesis the hippocampus (HP) through stimulation of MEL receptors or by blocking NMDA receptors, respectively. Non-effective doses KET administered with non-effective doses, both processes. The alpha isoform Calmodulin-dependent kinase II (CaMKII) is a downstream...