A5075232485- Circadian rhythm and melatonin
- Research on Leishmaniasis Studies
- Olfactory and Sensory Function Studies
- Cell death mechanisms and regulation
- Biochemical Analysis and Sensing Techniques
- Tryptophan and brain disorders
- Neurogenesis and neuroplasticity mechanisms
- Photoreceptor and optogenetics research
- Toxin Mechanisms and Immunotoxins
- Reproductive System and Pregnancy
- Advanced Neuroimaging Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Sleep and Wakefulness Research
- Parasitic Infections and Diagnostics
- Asthma and respiratory diseases
- Hereditary Neurological Disorders
- Zoonotic diseases and public health
- Alzheimer's disease research and treatments
- Growth Hormone and Insulin-like Growth Factors
- Nicotinic Acetylcholine Receptors Study
- Cholinesterase and Neurodegenerative Diseases
- Toxoplasma gondii Research Studies
- Mycobacterium research and diagnosis
- Amoebic Infections and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
Instituto Nacional de Psiquiatría
2017-2025
Rowan University
2025
Universidad Autónoma Metropolitana
2022
Universidad Nacional Autónoma de México
2008-2016
Melatonin (MEL) is a pleiotropic indolamine that reaches multiple intracellular targets. Among these, MEL binds to calmodulin (CaM) with high affinity. In presence of Ca2+, CaM CaM-dependent kinase II (CaMKII). The Ca2+-CaM/CaMKII pathway regulates myriad brain functions in different cellular compartments. Evidence showing the regulation this by scarce. Thus, our main objective was study interaction and its effects on CaMKII activity two microenvironments (aqueous lipidic) naturally...
Melatonin is synthesized by the pineal gland with a circadian rhythm in synchrony environmental light/dark cycle. A gradual increase circulating levels of melatonin occur after lights off, reaching its maximum around middle dark phase. Agonists receptors have proved effectiveness as antidepressants clinical trials. However, there contradictory evidence about potential antidepressant effect itself. Herein we studied administration mice at two zeitgeber times (ZT; ZT = 0 on; 12:12 L/D), one...
Schizophrenia (SZ) is a chronic disabling mental disorder with high heritability, and several immune-regulating genes have been implicated in its pathophysiology In this study, we investigated the expression of Toll-like receptors (TLRs) 1, 2, 6 peripheral blood monocytes from SZ patients healthy control subjects (HCSs) Mexican population, focusing on specific SZ-associated gene variants. Gene expressions were assessed by qPCR, protein was measured using flow cytometry. The secretory...
Several recent studies have demonstrated that virulence in Entamoeba histolytica is triggered the presence of both pathogenic and nonpathogenic bacteria species using vitro vivo experimental animal models. In this study, we examined samples aspirated from abscess material obtained patients who were clinically diagnosed with amebic liver (ALA) or pyogenic (PLA). To determine diversity bacterial abscesses, performed partial 16S rRNA gene sequencing. addition, E. dispar genotyped tRNA-linked...
Summary Leishmania mexicana is the causal agent of cutaneous leishmaniasis in Mexico. Dendritic cells (DC) are one host parasites. Intracellular microorganisms inhibit cell apoptosis as a strategy to ensure their survival infected cells. We have previously shown that promastigotes and amastigotes camptothecin‐induced monocyte‐derived dendritic (moDC), but mechanisms underlying inhibition DC by not been established. MAP kinases PI3K participate process modulated different species . As this...
Leishmania species are dimorphic protozoan parasites that live and replicate in the gut of sand flies as promastigotes or mammalian hosts amastigotes. Different immune cells, including DCs, receptors differ their involvement phagocytosis amastigotes recognition different species. In case L. mexicana, differences by DCs participation C-type lectin (CLRs) have not been established. present study, flow cytometry confocal microscopy were used to investigate monocyte-derived dendritic cells...
: Schizophrenia (SZ) is a multifactorial chronic psychiatric disorder with worldwide prevalence of 1%. Altered expression PLCβ occurs in SZ patients, suggesting alterations the PLCβ/IP
Major depressive disorder is a disabling disease with the number of affected individuals increasing each year. Current antidepressant treatments take between three to six weeks be effective forty percent patients being resistant treatment, making it necessary search for new treatments. Ketamine, phencyclidine hydrochloride derivative, given intravenously, induces rapid effect in humans. In mice, causes increased neurogenesis and antidepressant-like effects. However, also produces...
Background. According to national epidemiological surveillance records, in Mexico six intestinal infectious diseases (IID) are among the top communicable diseases. However, their incidence, relative importance, and spatial patterns have not been studied detail. Aims. We examine epidemiology of IID due bacteria protozoa identify which most important at two scales, what is integrated importance locally, how incidence correlates with Human Development Index (HDI). Methods. retrieved yearly...
Melatonin (MEL), an indolamine with diverse functions in the brain, has been shown to produce antidepressant-like effects, presumably through stimulating neurogenesis. We recently showed that combination of MEL ketamine (KET), NMDA receptor antagonist, robust effects mice, at doses that, by themselves, are non-effective and have no adverse effects. Here, we show KET/MEL increases neurogenesis a clone derived from human olfactory neuronal precursors, translational pre-clinical model for CNS....
The alterations that underlie the pathophysiology of schizophrenia (SCZ) include dysregulation structural and functional properties neurons. Among these, secretion neurotransmitters hormones, which plays a key role for neuronal communication development, is altered. Neuronal precursors from human olfactory epithelium have been recently characterized as reliable model studying etiopathogenesis neuropsychiatric diseases. Our previous work has shown melatonin enhances development morphological...
The pro-oxidant compound okadaic acid (OKA) mimics alterations found in Alzheimer’s disease (AD) as oxidative stress and tau hyperphosphorylation, leading to neurodegeneration cognitive decline. Although loss of dendrite complexity occurs AD, the study this post-synaptic domain chemical-induced models remains unexplored. Moreover, there is a growing expectation for therapeutic adjuvants counteract these brain dysfunctions. Melatonin, free-radical scavenger, inhibits modulates phosphatases,...
Species of the genus Leishmania are causal agents leishmaniasis, a disease with diametrically different clinical manifestations that have been attributed to species and host immune response. Some species, including mexicana, capable causing both localized cutaneous leishmaniasis (LCL) diffuse (DCL). Therefore, it is possible intraspecific differences may exist contribute development distinct forms. Dendritic cells (DC) important spp. parasites, cytokine production phagocytosis upon infection...
Asthma is the most prevalent cause of chronic respiratory diseases. Herein, we evaluate asthma burden in Mexico based on results from Global Burden Disease (GBD 2019) study 2019. Using data GBD 2019, estimated prevalence, incidence, mortality, and disability-adjusted lived years (DALYs) counts crude age-standardized rates per 100,000 people with a 95% uncertainty interval (UI) by sex age at national subnational levels 1990 to At level, affected 3.35 million (95% UI, 2.59-4.37) people, 606.0...