A5054459316- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Dermatology and Skin Diseases
- Asthma and respiratory diseases
- Phagocytosis and Immune Regulation
- Monoclonal and Polyclonal Antibodies Research
- Atherosclerosis and Cardiovascular Diseases
- Biomarkers in Disease Mechanisms
- Mast cells and histamine
- S100 Proteins and Annexins
- Toxin Mechanisms and Immunotoxins
- Cardiomyopathy and Myosin Studies
- Congenital heart defects research
- Psoriasis: Treatment and Pathogenesis
- IgG4-Related and Inflammatory Diseases
- Cutaneous lymphoproliferative disorders research
- Neuroendocrine Tumor Research Advances
- Pancreatitis Pathology and Treatment
University of Lübeck
2019-2024
Institute for Integrative and Experimental Genomics
2020
Bullous pemphigoid (BP) and pemphigus vulgaris (PV) are common autoimmune bullous dermatoses (AIBD) characterized by blisters erosions. Treatment options limited often insufficient. Immune checkpoint receptors play critical roles in immune homoeostasis self- tolerance. Targeting is highly efficient treatment of various cancers, but also associated with side effects.We therefore aimed to investigate the expression patients BP PV.We analysed programmed cell death protein 1 (PD-1), T-cell...
A balanced immune system is essential to maintain adequate host defense and effective self-tolerance. While an that fails generate appropriate response will permit infections develop, uncontrolled activation may lead autoinflammatory or autoimmune diseases. To identify drug candidates capable of modulating cell functions, we screened 1200 small molecules from the Prestwick Chemical Library for their property inhibit innate adaptive responses. Our studies focused specifically on interactions...
Abstract Investigating atherosclerosis and endothelial dysfunction has mainly become established in genetically modified ApoE −/− or LDL-R mice transgenic models. A new AAV-PCSK9DY DY mouse model with no genetic modification now been reported as an alternative model. Here, we aimed to employ this AAV-PCSK9 quantify the mechanical stiffness of surface, accepted hallmark for forerunner atherosclerosis. Ten-week-old male C57BL/6 N were injected (0.5, 1 5 × 10 11 VG) saline controls fed Western...
Epidermolysis bullosa acquisita (EBA) is a muco-cutaneous autoimmune disease characterized and caused by autoantibodies targeting type VII collagen (COL7). The treatment of EBA notoriously difficult, with median time to remission 9 months. In preclinical models, we previously discovered that depletion regulatory T cells (Treg) enhances autoantibody-induced, neutrophil-mediated inflammation blistering. Increased severity in Treg-depleted mice was accompanied an increased cutaneous expression...
Class I phosphoinositide 3-kinases (PI3K) have been implemented in pathogenesis of experimental epidermolysis bullosa acquisita (EBA), an autoimmune skin disease caused by type VII collagen (COL7) autoantibodies. Mechanistically, inhibition specific PI3K isoforms, namely PI3Kβ or PI3Kδ, impaired immune complex (IC)-induced neutrophil activation, a key prerequisite for EBA pathogenesis. Data unrelated to showed that activation is also modulated PI3Kα and γ, but their impact on the has, so...
Chronic blistering at the skin and/or mucous membranes, accompanied by a varying degree of inflammation, is clinical hallmark pemphigoid diseases that impose major medical burden. Pemphigoid are caused autoantibodies targeting structural proteins epithelial basement membrane. One pathogenic pathway and inflammation activation myeloid cells following Fc gamma receptor-dependent binding to skin-bound immune complexes. This process requires specific kinases, such as PI3Kδ, which have emerged...
Abstract Psoriasis is a chronic inflammatory skin condition. Repeated epicutaneous application of Aldara® (imiquimod) cream results in psoriasiform dermatitis mice. The Aldara®‐induced (AIPD) mouse model has been used to examine the pathogenesis psoriasis. Here, we forward genetics approach which compared AIPD that developed 13 different inbred strains identify genes and pathways modulated disease severity. Among our primary results, found severity differed substantially between mice these...
Regulatory T (Treg) cells induce immunologic tolerance by suppressing effector functions of conventional lymphocytes in the periphery. On other hand, immune silencing is mediated recognition phosphatidylserine (PS) on apoptotic phagocytes. Here we describe expression PS-binding protein Annexin V (ANXA5) CD4+ CD25hi Treg at mRNA and levels. ANXA5+ constitute about 0·1%-0·6% peripheral blood CD3+ cells, exhibit co-expression several markers, such as Forkhead box P3, programmed cell death...
(1) Background: Autoimmune pancreatitis (AIP) is mainly treated with steroids. Using an AIP mouse model, we investigated two potential alternatives, the transforming growth factor-β-activated kinase 1 inhibitor, takinib, and Janus tofacitinib. (2) Methods: In a multicenter preclinical study, MRL/MpJ mice were injected polyinosinic/polycytidylic acid (poly I:C) for weeks to induce AIP. They then four either takinib (25, 50, or 75 mg/kg body weight), tofacitinib (5, 10 15 mg/kg), dexamethasone...