A5051841517- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Seaweed-derived Bioactive Compounds
- Platelet Disorders and Treatments
- Phytochemical and Pharmacological Studies
- Genetic Mapping and Diversity in Plants and Animals
- Echinoderm biology and ecology
- Genetic and phenotypic traits in livestock
- Celiac Disease Research and Management
- Therapeutic Uses of Natural Elements
- Eosinophilic Disorders and Syndromes
- Marine Sponges and Natural Products
- Plant Molecular Biology Research
University of Lübeck
2019-2023
Bullous pemphigoid (BP) is an autoimmune blistering disease characterized by autoantibodies targeting type XVII collagen (Col17) with the noncollagenous 16A (NC16A) ectodomain representing immunodominant site. The role of additional extracellular targets Col17 outside NC16A has not been unequivocally demonstrated. In this study, we showed that ectodomain-reactive patient sera depleted in IgG induced dermal-epidermal separation a cryosection model indicating pathogenic potential anti-Col17...
Abstract Phenotypic variation of quantitative traits is orchestrated by a complex interplay between the environment (e.g. diet) and genetics. However, impact gene-environment interactions on phenotypic mostly remains elusive. To address this, we feed 1154 mice an autoimmunity-prone intercross line (AIL) three different diets. We find that diet substantially contributes to variability unmasks additional genetic susceptibility trait loci (QTL). By performing whole-genome sequencing AIL founder...
Fucoidans are natural polysaccharides mainly consisting of sulfated α-L-fucopyranose. A wide range biological activities has been attributed to fucoidans. However, their immunostimulatory role with respect structure-activity relationships is still under debate. To address this question, hyposulfated (hypoS), deacetylated (deAc), and both (hypoSdeAc) derivatives native Fucus evanescens fucoidan were used stimulate bone marrow–derived dendritic cells (BMDCs) macrophages (BMMs). Native induced...
Chronic blistering at the skin and/or mucous membranes, accompanied by a varying degree of inflammation, is clinical hallmark pemphigoid diseases that impose major medical burden. Pemphigoid are caused autoantibodies targeting structural proteins epithelial basement membrane. One pathogenic pathway and inflammation activation myeloid cells following Fc gamma receptor-dependent binding to skin-bound immune complexes. This process requires specific kinases, such as PI3Kδ, which have emerged...
Pemphigus and pemphigoid diseases are organ-specific autoimmune of the skin and/or mucous membranes, which caused by autoantibodies targeting structural proteins skin. In other diseases, a high prevalence primary antibody deficiencies was noted. Conversely, is reported in patients with deficiencies. With exception one study, pointing toward decrease IgG pemphigus patients, relative enrichment IgG4, serum immunoglobulin (Ig) concentrations had not been studied pemphigoid. Hence, we here aimed...
Abstract Background Dermatitis herpetiformis (DH) is a rare gluten-induced skin disorder characterized predominantly by IgA autoantibodies against endomysium, tissue transglutaminase (TG2/tTG), epidermal (TG3/eTG) and deamidated gliadin. To date, circulating autoantibody reactivity has not been systematically described. Objectives Characterization of serum reactivities in DH. Methods This multicentre international study analysed sera from 242 patients with DH taken at the time initial...
Fucoidans, sulfated polysaccharides extracted from brown algae (Phaeophyceae), have a wide spectrum of bioactivity. Studies molecular structures fucoidans and deciphering elements' impact on their biological activities are at active stage. The article shows the role sulfates acetyl groups in fucoidan isolated Fucus evanescens proinflammatory cytokines production by human heparinized unfractionated peripheral blood cells. Material Methods. cells were incubated with native (N) its deacetylated...