Meng Chen

ORCID: 0000-0003-0774-3133
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About
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Research Areas
  • Boron Compounds in Chemistry
  • Traditional Chinese Medicine Analysis
  • Maternal and Perinatal Health Interventions
  • Pharmaceutical studies and practices
  • Maternal and fetal healthcare
  • Medical Research and Treatments
  • Orthopedic Infections and Treatments
  • Organoboron and organosilicon chemistry
  • Traditional Chinese Medicine Studies
  • Urinary Bladder and Prostate Research
  • Ginseng Biological Effects and Applications
  • Cutaneous lymphoproliferative disorders research
  • Antifungal resistance and susceptibility
  • Flavonoids in Medical Research
  • Pharmaceutical Practices and Patient Outcomes
  • Acupuncture Treatment Research Studies
  • Pharmacology and Obesity Treatment
  • Pharmacogenetics and Drug Metabolism
  • Phytochemistry and Biological Activities
  • Natural Antidiabetic Agents Studies
  • Blood disorders and treatments
  • Pelvic floor disorders treatments
  • Shoulder Injury and Treatment
  • Natural product bioactivities and synthesis
  • Urinary Tract Infections Management

China National Institute of Standardization
2023-2025

Guangzhou University of Chinese Medicine
2025

Affiliated Hospital of North Sichuan Medical College
2025

Central University of Finance and Economics
2025

Stanford University
2015-2024

West China Second University Hospital of Sichuan University
2017-2024

Sichuan University
2017-2024

Ministry of Education of the People's Republic of China
2024

Anyang Hospital of Traditional Chinese Medicine
2023-2024

Jiangsu University
2023

Linezolid is an oxazolidinone antibacterial drug, and its therapeutic drug monitoring individualized treatment have been challenged since approval. With the in-depth clinical research of linezolid, we changed our attitude toward view treatment. On basis summarizing existing studies, based on practical experience each expert in their respective professional fields, formed this consensus. Our team specialists a multidisciplinary that includes pharmacotherapists, pharmacology specialists,...

10.3389/fpubh.2022.967311 article EN cc-by Frontiers in Public Health 2022-08-10

Luteolin is mainly metabolized by phase II enzymes in animals and humans with glucuronidation sulfation as the two known metabolic pathways. Although methylation of luteolin was reported previously, structure methylated metabolites involved process have not been clarified. In our study, metabolites, M1 (chrysoeriol) M2 (diosmetin), were identified urine after intravenous administration to rats, data suggested that mediated catechol-<i>O</i>-methyltransferase (COMT). When coadministered a...

10.1124/dmd.110.037333 article EN Drug Metabolism and Disposition 2011-01-05

Functionalization of carboranes in a vertex-specific manner is perennial challenge. Here, we report photocatalytic B-C coupling for the selective functionalization at boron site which most distal to carbon. This reaction was achieved by photo-induced decarboxylation carborane carboxylic acids generate vertex-centered carboranyl radicals. Theoretical calculations also demonstrate that more easily occurs bearing higher electron density owing lower energy barrier single-electron transfer...

10.1002/anie.202205672 article EN Angewandte Chemie International Edition 2022-06-07

Unilateral laminotomy for bilateral decompression (ULBD) has been adopted widely to treat lumbar spinal stenosis (LSS). The objective of the study is investigate clinical and radiological outcomes biportal endoscopic ULBD (BE-ULBD) uniportal (UE-ULBD).

10.1016/j.asjsur.2023.05.068 article EN cc-by-nc-nd Asian Journal of Surgery 2023-06-17

In sports medicine, tendon and ligament injuries are the most prevalent conditions, with booming of competition, incidence is gradually increasing, investigating more potent therapeutic options therefore becoming increasingly crucial. Platelet-rich plasma therapy has gained popularity as an effective secure treatment in recent years. Currently, a faceted systematic clear visual analysis lacking this research area.The literature related to using platelet-rich treat from 2003 2022 core dataset...

10.3389/fsurg.2023.1113491 article EN cc-by Frontiers in Surgery 2023-02-10

Intestinal ischemia/reperfusion (I/R) is a clinical emergency, which often causes lung injury with high morbidity and mortality. Although dexmedetomidine has been identified to have protective effect on caused by intestinal I/R, its specific mechanism still elucidated. In recent years, the cannabinoid (CB 2 ) receptor pathway found be involved in I/R of some organs. current study, we investigated whether CB contributes I/R-induced rats. Dexmedetomidine treatment upregulated expression...

10.1155/2020/6120194 article EN cc-by Oxidative Medicine and Cellular Longevity 2020-06-22

As security issues in vehicular networks continue to intensify, ensuring the trustworthiness of message exchanges among vehicles, infrastructure, and cloud platforms has become increasingly critical. Although trust authentication serves as a fundamental solution this challenge, existing models fail effectively address specific requirements networks, particularly defending against malicious evaluations. This paper proposes novel multidimensional evaluation framework that integrates both...

10.3390/math13091453 article EN cc-by Mathematics 2025-04-28

Four new neo-clerodane diterpenoid alkaloids, named scutebarbatines C-F (1-4), were isolated from the whole plants of Scutellaria barbata D. DON. Their structures elucidated by spectral analyses (UV, IR, FAB-MS, 1D-NMR and 2D-NMR). In vitro, compounds 1-4 showed significant cytotoxic activities against three human cancer cell lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, HT29 colorectal carcinoma cells, gave IC(50) values in range 3.9-7.8 muM.

10.1248/cpb.54.869 article EN Chemical and Pharmaceutical Bulletin 2006-01-01

Abstract Background Age at menarche (AAM) has shown different trends in women from ethnic and economic regions recent decades. Data on AAM among multiethnic living developing areas are scarce. Methods 1,275,000 26 ethnicities Yunnan Province, China, who were born 1965 to 2001 obtained the National Free Preconception Health Examination Project 2010 2018. The patterns of analysed according group, area residence, socioeconomic status. Results mean was 13.7 ± 1.21 years (95% CI 13.697–13.701),...

10.1186/s12889-021-11951-x article EN cc-by BMC Public Health 2021-10-19

Triptolide, an active ingredient of Chinese medicine plant Tripterygium wilfordii Hook.f., has been shown to exert anti-tumor, immunosuppressive, anti-inflammatory, and anti-fertility pharmacological effects. However, triptolide also causes severe side effects, which are manifested as toxicities in multiple organs. The aim this study was analyze the role extrahepatic cytochrome P450 enzymes triptolide-induced toxicity. Xh-CL mouse model with normal liver, but low expression levels used...

10.1186/s13020-018-0179-8 article EN cc-by Chinese Medicine 2018-04-23

Introduction: As participants of the national China Hospital Invasive Fungal Surveillance Net program, we sought to describe epidemiology and antifungal susceptibility patterns yeast isolates obtained from patients with invasive fungal infection at First Affiliated Zhengzhou University, China. Methods: A total 434 recovered blood other sterile body fluids were identified species by matrix-assisted laser desorption ionization –time flight mass spectrometry or without supplementation DNA...

10.2147/idr.s227839 article EN cc-by-nc Infection and Drug Resistance 2019-11-01

Salvia miltiorrhiza Bunge is an important medicinal plant used for the treatment of cardiovascular disease. Intraspecific hybridization between a male sterile line and inbred lines was followed by 39 F1 crossings. Cultivars "Zhongdanyaozhi No. 1" (ZD1) 2" (ZD2) were obtained. In 2012 2013 tests in Beijing, two cultivars compared with three widely accepted types, SDCK, SXCK HNCK from Shandong, Shanxi Henan provinces. The yield ZD1 ZD2 exceeded CKs more than 48.2% 39.2%, respectively;...

10.1371/journal.pone.0162691 article EN cc-by PLoS ONE 2016-09-22
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