A5023286322- Power Systems and Technologies
- High voltage insulation and dielectric phenomena
- Smart Grid and Power Systems
- Gut microbiota and health
- Liver physiology and pathology
- Power Systems and Renewable Energy
- Smart Grid Security and Resilience
- Antibiotics Pharmacokinetics and Efficacy
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Metabolomics and Mass Spectrometry Studies
- Liver Disease Diagnosis and Treatment
- Statistical Methods and Inference
- Statistical Methods and Bayesian Inference
- Integrated Energy Systems Optimization
- Smart Grid Energy Management
- Microgrid Control and Optimization
- Neurological Disease Mechanisms and Treatments
- Endoplasmic Reticulum Stress and Disease
- Epigenetics and DNA Methylation
- Thermal Analysis in Power Transmission
- Reproductive tract infections research
- High-Voltage Power Transmission Systems
- Renal Diseases and Glomerulopathies
- Spectroscopy and Laser Applications
Nanjing Drum Tower Hospital
2020-2025
Shanghai Jiao Tong University
2024
Shanghai Electric (China)
2018-2024
Hubei University of Technology
2021-2023
State Grid Nanjing Power Supply Company (China)
2018-2023
Children's Hospital of Zhejiang University
2016-2022
Emory University
2020-2022
Shanghai Academy of Agricultural Sciences
2022
Ministry of Agriculture and Rural Affairs
2022
Hefei University of Technology
2021
Linezolid is an oxazolidinone antibacterial drug, and its therapeutic drug monitoring individualized treatment have been challenged since approval. With the in-depth clinical research of linezolid, we changed our attitude toward view treatment. On basis summarizing existing studies, based on practical experience each expert in their respective professional fields, formed this consensus. Our team specialists a multidisciplinary that includes pharmacotherapists, pharmacology specialists,...
Abstract Acute severe autoimmune hepatitis (AS‐AIH) is characterized by rapid progression and poor prognosis, with a current lack of effective targeted treatments. Stem cell therapy has demonstrated significant therapeutic promise across various diseases. However, the intricate pathogenesis AS‐AIH hindered widespread utilization mesenchymal stem cells (MSCs) in this domain. Herein, it that necroptosis, as primary mode death AIH, crucial causing AS‐AIH. Inflammatory macrophages are population...
M2-polarized macrophages, also known as alternatively activated have long been associated with pulmonary fibrosis; however, the mechanism has not fully defined. Gab1 and Gab2 proteins belong to Gab family of adaptors are integral components signal specificity in response various extracellular stimuli. In this report, we found that levels both were elevated macrophages isolated from bleomycin-induced fibrotic lungs. vitro Gab1/2 deficiency bone marrow-derived abrogated IL-4–mediated M2...
Background As a crucial constituent part of Polycomb repressive complex 2, PHD finger protein 19 (PHF19) plays pivotal role in epigenetic regulation, and acts as critical regulator multiple pathophysiological processes. However, the exact roles PHF19 cancers remain enigmatic. The present research was primarily designed to provide prognostic landscape visualizations cancers, study correlations between expression immune infiltration characteristics tumor microenvironment. Methods Raw data...
Background: Correct dosing of antimicrobial drugs in septic patients receiving continuous renal replacement therapy (CRRT) is complex. This study aimed to evaluate the effects adjustments performed by pharmacists on length intensive care unit (ICU) stay, ICU cost, and adverse drug events (ADEs). Methods: A single-center, 2-phase (pre-/post-intervention) was an a university-affiliated hospital. Septic CRRT post-intervention phase received specialized service from critical pharmacists, whereas...
The pathogenesis of non-alcoholic fatty liver disease is currently unclear, however, lipid accumulation leading to endoplasmic reticulum stress appears be pivotal in the process. At present, FOXO1 known involved NAFLD progression. relationship between necroptosis and steatohepatitis has been great research interest more recently. However, whether regulates ER mice fed with a high fat diet not clear. Therefore, this study we analyzed steatohepatitis, stress, necroptosis.Male C57BL/6J were an...
Trans-differentiation of quiescent hepatic stellate cells (HSC) into myofibroblast is considered the linchpin liver fibrosis. A myriad signaling pathways contribute to HSC activation and consequently Epidermal growth factor (EGF) family cytokines signal through cognate receptor EGFR promote activation. In present study we investigated transcription regulation epiregulin (EREG), an ligand, during We report that EREG expression was significantly up-regulated in activated HSCs compared isolated...
The impact of continuous renal replacement therapy (CRRT) on drug removal is complicated; pharmacist dosing adjustment for these patients may be advantageous. This study aims to describe the development and implementation critically ill receiving CRRT examine effectiveness interventions.A comparative was conducted in an intensive care unit (ICU) a university-affiliated hospital. Patients intervention group received specialized pharmacy service from pharmacists, whereas no-intervention...
Matched-set data arise frequently in microbiome studies. For example, we may collect pre- and post-treatment samples from a set of individuals, or use important confounding variables to match case participants one more control participants. Thus, there is need for statistical methods comprised matched sets, test hypotheses against traits interest (e.g., clinical outcomes environmental factors) at the community level and/or operational taxonomic unit (OTU) level. Optimally, these should...
Liver fibrosis is mediated by myofibroblasts, a specialized cell type involved in wound healing and extracellular matrix production. Hepatic stellate cells (HSC) are the major source of myofibroblasts fibrotic livers. In present study we investigated involvement CXXC-type zinc-finger protein 5 (CXXC5) HSC activation underlying mechanism. Down-regulation CXXC5 was observed activated HSCs compared to quiescent both vivo vitro . accordance, over-expression suppressed activation. RNA-seq...
Abstract Background Hepatic ischemia-reperfusion injury (IRI) is considered as an effecting factor for hepatocellular carcinoma (HCC) recurrence. Th17/Treg cells are a pair of essential components in adaptive immune response liver IRI, and forkhead box O1 (FOXO1) has the properties maintaining function phenotype cells. Herein, we illuminated correlation between cell balance FOXO1 IRI-induced HCC Methods RNA sequencing was performed on naive CD4+ T from normal IRI model mice to identify...
Young men who have sex with (YMSM) represent a particularly high-risk group for HIV acquisition in the US, despite similarly reported rates of sexual activity as older, adult MSM (AMSM). Increased infection among YMSM compared to AMSM could be partially attributable differences within rectal mucosal (RM) immune environment associated earlier debut and less lifetime exposure receptive anal intercourse. Using an ex vivo explant challenge model, we found that tissues from supported higher...
To solve the configuration issue when using International Electrotechnical Commission (IEC) 61850 for distributed intelligence in Distribution Automation Systems (DAS), this paper proposes solution terms of semantic models and processing methods. Firstly, special requirements DAS are analyzed, consisting system boundary a project, topology applications, automatic identification Intelligent Electronic Devices (IED). The new Process, Line, other elements then presented based on System...
This paper presents the fracture failure mechanism of composite insulators that have been deployed for only one year on 750 kV transmission lines in strong wind areas. Investigations indicate flexible shed structure was vulnerable to flow-induced oscillation, which further brought cracking root. The interactive process fatigue and reviewed by inspecting failed samples gain insight into mechanism. theory silicone rubber introduced illustrate resistance material. Simulations load stress...
In the environment of active distribution network, more distributed control devices are deployed to enhance system reliability and flexibility. The master station automation is required transfer real‐time topology information numerous field for implementing operations. To reduce computational burden make it autonomous agents utilise information, this study proposes a fully solution processing applications. It reduces grid an undirected graph, divides into subgraphs executes adaptation graph...
Vascular endothelial (VE)-cadherin junctional localization is known to play a central role in vascular development, barrier integrity, and homeostasis. The sarcoma homology domain containing protein tyrosine phosphatase (SHP)2 has been shown be involved regulating function; however, the mechanisms remain largely unknown. In this work SHP2 knockdown an HUVEC monolayer increased VE-cadherin internalization permeability. Loss of specifically augmented GTPase activity ADP-ribosylation factor...
This study assessed the efficacy and safety of tigecycline in children with life-threatening infections.We retrospectively reviewed clinical records patients treated from June 2012 to May 2014 a Chinese tertiary centre.The comprised 24 (14 male) median age four years (range, 50 days-12 years). The most frequently isolated microorganism, common isolation site type infection were Acinetobacter baumannii, tracheal aspirate fluid ventilator-associated pneumonia, respectively. Tigecycline was...
Tetracycline may cause tooth discoloration when used in young children during development. Whether tigecycline, a tetracycline derivative, has either similar adverse event or not remains unclear.
We previously developed the LDM for testing hypotheses about microbiome that performs test at both community level and individual taxon level. The can be applied to relative abundance data presence-absence separately, which work well when associated taxa are abundant rare, respectively. Here we propose LDM-omni3 combines analyses scales, thereby offering optimal power across scenarios with different association mechanisms. new is available wide range of types supported by LDM.The has been...
Abstract Currently, there is still a lack of novel and effective drug targets to improve the prognosis hepatocellular carcinoma (HCC). Additionally, role CHEK2 in HCC has not been reported yet. The eQTLgen database two Genome-Wide Association Study (GWAS) datasets (ieu-b-4953, ICD10 C22.0) were used find target: CHEK2. Next, Colony, Edu, β-gal, cell cycle analysis facilitated evaluate knockout HCC. In addition, Nultin-3 was added apoptosis TP53-mutated cells with knockout. Furthermore,...
Aim: To evaluate the impact of CYP3A4*1G, CYP3A5*3 and ABCB1-C3435T polymorphisms on tacrolimus concentrations, efficacy tolerance in pediatric primary nephrotic syndrome. Methods: Dose-adjusted concentrations (C0/D), daily dose, frequency time to relapse, cumulative remission days, adverse reactions 65 Chinese patients with various genotypes were retrospectively collected compared. Results: C0/D increased CYP3A4*1/*1, CYP3A5*3/*3 CYP3A4*1/*1-3A5*3/*3 diplotype carriers by 38.4, 69.7 40.9%...