A5057394233- Acute Myeloid Leukemia Research
- Immune cells in cancer
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Bone and Joint Diseases
- Glioma Diagnosis and Treatment
- Hematological disorders and diagnostics
Princess Máxima Center
2022-2025
A better understanding of lymphocyte dynamics during current treatment regimens in pediatric AML is urgently needed to understand whether the application bispecific T-cell-engagers (BiTEs) periods low tumor burden could be a viable strategy. In this study, we found that induction 1, comprising mitoxantrone-etoposide-cytarabine nearly all patients (as part NOPHO-DBH AML-2012 protocol), led preserved or increased relative abundances alongside marked blast reduction most cases. This was...
Abstract Background Current treatment options for pediatric high-grade brain tumors are limited, with poor 5-year overall survival rates. While immunotherapy is promising these patients, the composition of their tumor immune microenvironment (TIME) still not fully understood, due to limited availability material research. Given high abundance tissue fragments obtained using cavitron ultrasonic surgical aspirator (CUSA), , samples could serve as a resource research and diagnostic purposes....
Abstract Because of the low mutational burden and consequently, fewer potential neoantigens, children with acute myeloid leukemia (AML) are thought to have a T cell-depleted or ‘cold’ tumor microenvironment may likelihood response cell-directed immunotherapies. Understanding composition, phenotype, spatial organization cells other microenvironmental populations in pediatric AML bone marrow (BM) is essential for informing future immunotherapeutic trials about targetable immune-evasion...
Abstract Because of the low mutational burden and consequently, fewer potential neoantigens, children with acute myeloid leukemia (AML) are thought to have a T cell-depleted or ‘cold’ tumor microenvironment may likelihood response cell-directed immunotherapies. Understanding composition, phenotype, spatial organization cells other microenvironmental populations in pediatric AML bone marrow (BM) is essential for informing future immunotherapeutic trials about targetable immune-evasion...