A5013453828- Osteoarthritis Treatment and Mechanisms
- Inflammatory mediators and NSAID effects
- Computational Drug Discovery Methods
- Cytokine Signaling Pathways and Interactions
- Cell Adhesion Molecules Research
- Angiogenesis and VEGF in Cancer
- Bone Metabolism and Diseases
- Acute Myeloid Leukemia Research
- Axon Guidance and Neuronal Signaling
- Receptor Mechanisms and Signaling
- Bone and Joint Diseases
- Gene Regulatory Network Analysis
- Biomarkers in Disease Mechanisms
- Single-cell and spatial transcriptomics
- Pharmacological Effects of Natural Compounds
- Hematopoietic Stem Cell Transplantation
- Hematological disorders and diagnostics
- Chemokine receptors and signaling
- Immune Response and Inflammation
Erasmus MC
2021-2024
Erasmus University Rotterdam
2020-2022
A better understanding of lymphocyte dynamics during current treatment regimens in pediatric AML is urgently needed to understand whether the application bispecific T-cell-engagers (BiTEs) periods low tumor burden could be a viable strategy. In this study, we found that induction 1, comprising mitoxantrone-etoposide-cytarabine nearly all patients (as part NOPHO-DBH AML-2012 protocol), led preserved or increased relative abundances alongside marked blast reduction most cases. This was...
In osteoarthritis, chondrocytes tend to acquire a hypertrophic phenotype, which contributes the modification of extracellular matrix, resulting in permanent cartilage changes. mouse chondrocytes, pro-inflammatory macrophages and cytokines have been shown stimulate hypertrophy via activation nuclear factor kappa B (NF-κB) pathway. Whether or not this also occurs human remains unclear. We therefore aimed investigate whether hypertrophy-like responses are driven mainly by intrinsic inflammatory...
Corticosteroids such as triamcinolone acetonide (TAA) are potent drugs administered intra-articularly an anti-inflammatory therapy to relieve pain associated with osteoarthritis (OA). However, the ability of early TAA intervention mitigate OA progression and modulate immune cell subsets remains unclear. Here, we sought understand effect intra-articular injection on progression, local macrophages, peripheral blood monocytes.
Abstract Background Without the availability of disease-modifying drugs, there is an unmet therapeutic need for osteoarthritic patients. During osteoarthritis, homeostasis articular chondrocytes dysregulated and a phenotypical transition called hypertrophy occurs, leading to cartilage degeneration. Targeting this phenotypic has emerged as potential strategy. Chondrocyte phenotype maintenance switch are controlled by intricate network intracellular factors, each influenced myriad feedback...
Abstract The bone marrow microenvironment is critical for B-cell acute lymphoblastic leukemia (B-ALL) but its cellular heterogeneity remains poorly defined. Here, we employed single-cell RNA sequencing to comprehensively characterize the stromal and hematopoietic niches in pediatric B-ALL. Our analysis revealed two distinct mesenchymal cell (MSC) populations as primary leukemia-supportive niches: early progenitors adipogenic progenitors. Single-cell transcriptomic infers that ALL blasts use...
ABSTRACT Without the availability of disease-modifying drugs, there is an unmet therapeutic need for osteoarthritic patients. During osteoarthritis, homeostasis articular chondrocytes dysregulated and a phenotypical transition called hypertrophy occurs, leading to cartilage degeneration. Targeting this phenotypic has emerged as potential strategy. Chondrocyte phenotype maintenance switch are controlled by intricate network intracellular factors, each influenced myriad feedback mechanisms,...
Abstract Low-grade inflammation and pathological endochondral ossification are processes underlying the progression of osteoarthritis, most prevalent joint disease worldwide. In this study, data mining on publicly available transcriptomic datasets revealed EPHA2, a receptor tyrosine kinase associated with cancer, to be both in osteoarthritis. A computational model cellular signaling networks chondrocytes predicted that silico activation EPHA2 healthy increases inflammatory mediators triggers...