A5030127474- Computational Drug Discovery Methods
- French Historical and Cultural Studies
- Grouting, Rheology, and Soil Mechanics
- Innovations in Concrete and Construction Materials
- Rheumatoid Arthritis Research and Therapies
- Cultural Identity and Heritage
- Osteoarthritis Treatment and Mechanisms
- Bioinformatics and Genomic Networks
- Effects and risks of endocrine disrupting chemicals
- Hormonal and reproductive studies
- French Urban and Social Studies
- Concrete and Cement Materials Research
- Infectious Diseases and Tuberculosis
- Historical Studies and Socio-cultural Analysis
- Building materials and conservation
- Concrete Properties and Behavior
- Modular Robots and Swarm Intelligence
- French Language Learning Methods
- Microbial Applications in Construction Materials
- Gene Regulatory Network Analysis
- Agriculture and Rural Development Research
- Hematological disorders and diagnostics
- Mental Health and Patient Involvement
- Geological Modeling and Analysis
- Spondyloarthritis Studies and Treatments
Promethera Biosciences (Belgium)
2024
KU Leuven
2018-2024
Valley Presbyterian Hospital
2023
Physiological Society
2022
Prometheus Research (United States)
2021-2022
Biomechanics Institute of Valencia
2022
Centre Hospitalier d'Albi
2008
National Institute of Standards and Technology
1995
Université Laval
1974-1993
Université de Montréal
1993
The value of in silico methods drug development and evaluation has been demonstrated repeatedly convincingly. While their benefits are now unanimously recognized, international standards for evaluation, accepted by all stakeholders involved, still to be established. In this white paper, we propose a risk-informed framework mechanistic model credibility evaluation. To properly frame the proposed verification validation activities, concepts such as context use, regulatory impact risk-based...
Abstract Background Bones have a remarkable capacity to heal upon fracture. Yet, in large defects or compromised conditions healing processes become impaired, resulting delayed non-union. Current therapeutic approaches often utilize autologous allogeneic bone grafts for augmentation. However, limited availability of these tissues and lack predictive biological response result limitations clinical demands. Tissue engineering using viable cell-based implants is strategic approach address unmet...
In silico medicine describes the application of computational modelling and simulation (CM&S) to study, diagnosis, treatment or prevention a disease. Tremendous research advances have been achieved facilitate use CM&S in clinical applications. Nevertheless, uptake practice is not always timely accurately reflected literature. A clear view on current awareness, actual usage opinions from clinicians needed identify barriers opportunities for future medicine. The aim this study...
Abstract Background Complex immunophenotypic repertoires defining discrete adipose-derived stem cell (ASC) subpopulations may hold a key toward identifying predictors of clinical utility. To this end, we sorted out the freshly established ASCs four (SPs) according to specific pattern co-expression six surface markers, CD34, CD73, CD90, CD105, CD146, and CD271, using polychromatic flow cytometry. Method Using cytometry-associated sorting analysis, gating parameters were set select for CD73 +...
The added value of in silico models (including quantitative systems pharmacology models) for drug development is now unanimously recognized. It is, therefore, important that the standards used are commonly acknowledged by all parties involved. On April 25 and 26, 2019, a multistakeholder workshop on validation challenges was organized Belgium. As an outcome, White Paper foreseen 2020 model verification validation. Drug research, design, has long-standing tradition use methodologies. In...
Abstract Decay of luminescence from the well characterized humic substance, Armdale fulvic acid, has been measured with both nanosecond and picosecond flash excitation. In aerated deaerated solutions at pH between 2 7, three characteristic times are required to account for decay envelope these vary over only a narrow range. The in vicinity 200 picosecond, nanosecond, 7 respectively. Cu(II) complexation led static quenching.
Abstract Background Without the availability of disease-modifying drugs, there is an unmet therapeutic need for osteoarthritic patients. During osteoarthritis, homeostasis articular chondrocytes dysregulated and a phenotypical transition called hypertrophy occurs, leading to cartilage degeneration. Targeting this phenotypic has emerged as potential strategy. Chondrocyte phenotype maintenance switch are controlled by intricate network intracellular factors, each influenced myriad feedback...
The use of the fast Fourier transform in processing photographic data obtained from picosecond continuum spectroscopy is described. resulting reduction complexity and computation time has permitted all acquisition to be carried out with an eight-bit microcomputer. Specific examples some key problems that are peculiar this spectroscopic technique methods overcoming these discussed. Experimental results serve illustrate both experimental itself as well versatility reliability algorithm...
A. D. Kirk, C. H. Langford, S. Joly, R. Lesage and K. Sharma, J. Chem. Soc., Commun., 1984, 961 DOI: 10.1039/C39840000961