A5007212842- Wound Healing and Treatments
- Diabetes Management and Research
- Microfluidic and Capillary Electrophoresis Applications
- Genetic diversity and population structure
- Diabetic Foot Ulcer Assessment and Management
- Advancements in Transdermal Drug Delivery
- Innovative Microfluidic and Catalytic Techniques Innovation
- Advanced Cellulose Research Studies
- Antimicrobial agents and applications
- Health Literacy and Information Accessibility
- Vitamin D Research Studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Synthetic Organic Chemistry Methods
- Parasite Biology and Host Interactions
- Marine Biology and Ecology Research
- Aquatic Ecosystems and Biodiversity
- Burn Injury Management and Outcomes
- Child Development and Digital Technology
- Mass Spectrometry Techniques and Applications
- Diet and metabolism studies
- Fish Biology and Ecology Studies
- Botulinum Toxin and Related Neurological Disorders
- Misinformation and Its Impacts
- Adipose Tissue and Metabolism
- Inhalation and Respiratory Drug Delivery
Joanneum Research
2014-2023
Medical University of Graz
2012-2022
Institute for Biomedicine
2013-2020
Fraunhofer Institute for Silicate Research
2019-2020
Shriners Hospitals for Children - Galveston
2019
Center For Biomarker Research In Medicine
2016
University of Graz
2011-2013
Carleton University
2004-2007
Ministry of the Interior
2007
Vitamin D is well known for its effects on bone mineralisation but has also been attributed immunomodulatory properties. It positively influences human health, in vivo data describing vitamin the gut microbiome are missing. We aimed to investigate of oral D3 supplementation mucosa-associated and stool as CD8(+) T cells healthy volunteers.This was an interventional, open-label, pilot study. Sixteen volunteers (7 females, 9 males) were endoscopically examined access a total 7 sites. sampled...
Bariatric surgery is currently one of the most effective treatments for obesity and leads to significant weight reduction, improved cardiovascular risk factors overall survival in treated patients. To date, studies focused on short-term effects bariatric metabolic profile found high variation individual responses surgery. The aim this study was identify relevant changes not only shortly after (Roux-en-Y gastric bypass) but also up year intervention by using untargeted metabolomics. 132 serum...
Background Many children and adolescents are surrounded by smartphones, tablets, computers know how to search the internet for almost any information. However, very few of them select proper information from reliable sources. This can become a problem when health issues concerned, where it is vital identify incorrect or misleading The competence critically evaluate digital on increasing importance adolescents. Objective aim this study was assess rate their internet-based literacy actual...
Abstract Burn injuries initiate numerous processes such as heat shock response, inflammation and tissue regeneration. Reliable burn models are needed to elucidate the exact sequence of local events be able better predict when triggers systemic inflammatory processes. In contrast other ex vivo skin culture approaches, we used fresh abdominal explants introduce contact injuries. Histological ultrastructural analyses confirmed a partial-thickness pathology. Gene expression patterns cytokine...
Understanding how genetic variation is generated and maintained in natural populations, this process unfolds a changing environment, remains central issue biological research. In work, we analysed patterns of diversity from several populations three cichlid species Lake Tanganyika parallel, using the mitochondrial DNA control region. We sampled inhabiting littoral rocky habitats both very deep shallow areas lake. hypothesized that former would constitute relatively older, more stable...
Abstract Background Carassius gibelio , a cyprinid fish from Eurasia, has the ability to reproduce both sexually and asexually. This is also known as an invasive species which colonized almost all continental Europe, most likely originating Asia Eastern Europe. Populations of asexually reproducing individuals exist in sympatry. In this study we try elucidate advantages such mixed type reproduction. We investigate dynamics two sympatric populations with sexual asexual reproduction...
Spermidine is a natural polyamine which was shown to prolong lifespan of organisms and improve cardiac cognitive function. also reported reduce inflammation modulate T-cells. Autophagy one the mechanisms that spermidine exerts its effect. vital for β-cell homeostasis autophagy deficiency lead exacerbated diabetes in mice. The effect type 1 pathogenesis remains be elucidated. Therefore, we examined treatment non-obese diabetic (NOD) mice, mouse model diabetes. NOD mice were given untreated or...
We studied feeding site selection and impacts by benthic fish (flounder skates) on the amphipod Corophium volutator, an ecologically-important species in muddy intertidal communities. determined that foraged mainly areas had high densities of amphipods, a mudflat Nova Scotia, Canada. This observation was based recording sediments displaced where samples amphipods also were taken. From gut-content analysis, we found fed almost entirely C. most consumed smaller than expected collected from...
SUMMARY In this paper, we describe the occurrence of a microsporidian parasite in female-biased populations an intertidal amphipod, Corophium volutator (Pallas), at mudflat sites Bay Fundy, Canada. Sequence data for parasite's 16S rDNA indicate that it is novel species. This was found principally female host gonads, indicating might be vertically transmitted, sex-distorting microparasite. At 4 each sampled early and mid-summer, prevalence varied from 0 to 21%. lab, infected mothers gave rise...
In order to detect introgression of other Alectoris genus species into wild populations Spanish rufa, we studied a sample 93 red-legged partridges (supposed be A. rufa) captured in the island Majorca. A set 31 chukar (Alectoris chukar) from Cyprus and 33 (A. one farm were also provide suitable for comparison. Factorial correspondence analysis on microsatellite genotypes supported clear distinction birds Cyprus, whereas Majorca overlapped wide area. The existence mitochondrial DNA 16...
We investigated the impact of two different injection strategies on pharmacokinetics and pharmacodynamics insulin aspart in vivo an open-label, two-period crossover study verified changes surface-to-volume ratio ex vivo.Before clinical trial, was injected into explanted human abdominal skin flaps. The subcutaneous depot assessed by microfocus computed tomography that compared 1 bolus 18 IU with 9 dispersed boluses 2 IU. These were then tested vivo, 12 C-peptide-negative type diabetic...
Background: Successful control of hyperglycemia has been shown to improve outcomes for diabetes patients in a clinical setting. We assessed the quality physician-based glycemic management two general wards, considering most recent recommendations noncritically ill (<140 mg/dl premeal glucose). Methods: Quality 50 wards (endocrinology, cardiology) was retrospectively by analyzing blood glucose (BG) levels, effort, and online questionnaire. Results: Glycemic clearly above recommended target...
In burn injuries, risk factors and limitations to treatment success are difficult assess clinically. However, local cellular responses characterized by specific gene-expression patterns. MicroRNAs (miRNAs) single-stranded, non-coding RNAs that regulate mRNA expression on a posttranscriptional level. Secreted through exosome-like vesicles (ELV), miRNAs intracellular signalers epigenetic regulators. To date, their role in the regulation of early response remains unclear. Here, we identified 43...
To compare the time profile of insulin detemir and human concentrations in interstitial fluid (ISF) subcutaneous adipose tissue during constant i.v. infusion to investigate relationship between pharmacokinetics both molecules plasma ISF tissue.During a 6-h hyperinsulinaemic-euglycaemic clamp (plasma glucose level 8 mmol/l) (21 42 pmol/min/kg) or (209 417 were infused eight rats per dose level. Open flow microperfusion (OFM) was used continuously assess tissue.At lower rate, appeared...
We investigated the functional significance of intersexuality in amphipod Corophium volutator, a key species soft-bottom intertidal communities. Intersexes this possess morphological and anatomical characters both males females. Two broad types intersexes were identified: those with nonsetose oostegites two penial papillae (Type I), setose one or II). found little evidence that function as females, but some females housed experimentally became ovigerous, indicating can males. Females mated...
Trichoderma spp. are used extensively in industry and routinely disposed of landfill sites as spent biomass from fermentation plants. However, little is known regarding the environmental fate this biomass. We tracked survival T. reesei strain QM6A#4 (a derivative QM6A marked with a recombinant construct) over 6-month period laboratory-contained, intact soil-core microcosms incubated growth chamber. Survival was tested 3 different soils effect plant rhizosphere (bush lima beans, Phaseolus...
With about 250 endemic species, Lake Tanganyika contains an extraordinarily diverse cichlid fish fauna, and thus represents ideal model system for the study of pathways processes speciation. The Lamprologini form most species-rich tribe in comprising 100 species seven genera, which are to lake. They territorial substrate-breeders represent a monophyletic tribe. By combined analysis population genetics geometric morphometric markers, we assessed gene flow among three populations highly...
Aims To find an explanation for the lower potency of insulin detemir observed in humans compared with unmodified human by investigating and concentrations directly at level peripheral insulin‐sensitive tissues vivo . Methods Euglycaemic‐hyperinsulinaemic clamp experiments were performed healthy volunteers. Human was administered i.v. 6 pmol/kg/min 60 pmol/kg/min, achieving a comparable steady‐state pharmacodynamic action. In addition, doubled to 120 pmol/kg/min. Minimally invasive open‐flow...