A5050234908- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Diagnosis and treatment of tuberculosis
- Research on Leishmaniasis Studies
- Infectious Diseases and Mycology
- Endoplasmic Reticulum Stress and Disease
- RNA regulation and disease
- Biochemical and Molecular Research
- Trypanosoma species research and implications
- Helicobacter pylori-related gastroenterology studies
- Digital Imaging for Blood Diseases
- Infectious Diseases and Tuberculosis
- Insect symbiosis and bacterial influences
- Bacteriophages and microbial interactions
- Analytical Methods in Pharmaceuticals
- Insect-Plant Interactions and Control
University of Liverpool
2021-2023
University of Manchester
2021
King Faisal Specialist Hospital & Research Centre
2017-2019
King Abdulaziz Medical City
2017
Pitié-Salpêtrière Hospital
2017
Sorbonne Université
2017
Despite low infectious potential of extrapulmonary tuberculosis (EPTB), it poses significant clinical challenges in terms diagnosis and treatment monitoring. Understanding the main demographical risk factors for disease characteristics EPTB plays a crucial role speeding up process improving overall experience. The aim this study was to investigate among adults adolescents first time Saudi Arabia. A cross-sectional multicenter carried out on collection 902 Mycobacterium complex (MTBC)...
Background: In Saudi Arabia, cross-border transmission of multidrug-resistant (MDR) Mycobacterium tuberculosis complex (MTBC) strains might be particularly fostered by high immigration rates. Herein, we aimed to elucidate the dynamics MDR-MTBC and reveal a detailed prediction all resistance-conferring mutations for first- second-line drugs. Methods: We investigated collected between 2015 2017 from provincial mycobacteria referral laboratories compared demographic clinical parameters cohort...
Growing evidences suggested that the Mycobacterium tuberculosis complex (MTBC) lineages can determine clinical outcome of pulmonary and extra-pulmonary tuberculosis. However, limited data only available revealing such association bacterial genotypes phenotypes from immigrant rich countries. A multicenter study has been carried out on a collection 2092 (1003 extrapulmonary 1089 pulmonary) MTBC isolates. Genotyping all isolates were by spoligotyping 24 loci based MIRU-VNTR typing....
eIF2B is the guanine nucleotide exchange factor (GEF) required for cytoplasmic protein synthesis initiation in eukaryotes and its regulation within integrated stress response (ISR). It activates partner eIF2, thereby promoting translation initiation. Here we provide evidence through biochemical genetic approaches that can bind directly to GTP this enhance rate of GEF activity toward eIF2-GDP vitro. binds a subcomplex eIF2Bγ ε subunits. The amino-terminal domain shares structural homology...
Background Incidences of nontuberculous mycobacteria (NTM) causing pulmonary and extrapulmonary diseases are reportedly increasing globally the current epidemiologic situation in Saudi Arabia remains unclear. To study such trend, we carried out a nationwide systematic epidemiological focusing on NTM for first time country. Methods/Principle findings A collection isolates with clinical demographical data was conducted period 24 months. Primary species identification by line probe assays...
We explored in detail the nationwide existence of Mycobacterium riyadhense Saudi Arabia. In 18 months, 12 new cases M. infection were observed, predominantly among nationals, as a cause pulmonary disease. may be emerging more common pathogen
Trypanosomatids are a diverse family of protozoan parasites, some which cause devastating human and livestock diseases. There two distinct infection life cycles in trypanosomatids; species complete their entire cycle single host (monoxenous) while others infect hosts (dixenous). Dixenous trypanosomatids mostly vectored by insects, the trypanosomatid diseases caused mainly parasites. While prevalence has been described for subsets trypanosomatids, little is known about whether monoxenous...
eIF2B is the guanine nucleotide exchange factor (GEF) required for cytoplasmic protein synthesis initiation in eukaryotes and its regulation within integrated stress response (ISR). It activates partner eIF2 thereby promoting translation initiation. Here we provide evidence through biochemical genetic approaches that can bind directly to GTP this enhance rate of GEF activity towards eIF2–GDP vitro. binds a subcomplex eIF2Bγ ε subunits. The amino-terminal domain shares structural homology...
Abstract Trypanosomatids are a diverse family of protozoan parasites, some which cause devastating human and livestock diseases. There two distinct infection life-cycles in trypanosomatids; species complete their entire life-cycle single host (monoxenous) while others infect hosts (dixenous). Dixenous trypanosomatids mostly vectored by insects, the trypanosomatid diseases caused mainly parasites. While prevalence has been described for subsets trypanosomatids, little is known about whether...