Shantanu Sinha

ORCID: 0000-0003-0796-2694
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About
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Research Areas
  • Sports injuries and prevention
  • Advanced MRI Techniques and Applications
  • Muscle activation and electromyography studies
  • Advanced Neuroimaging Techniques and Applications
  • Sports Performance and Training
  • MRI in cancer diagnosis
  • Lower Extremity Biomechanics and Pathologies
  • Tendon Structure and Treatment
  • Cardiac Imaging and Diagnostics
  • Pelvic floor disorders treatments
  • Elasticity and Material Modeling
  • Cerebral Palsy and Movement Disorders
  • Medical Imaging Techniques and Applications
  • Radiomics and Machine Learning in Medical Imaging
  • Muscle Physiology and Disorders
  • Advanced Sensor and Energy Harvesting Materials
  • Anorectal Disease Treatments and Outcomes
  • Cardiovascular Function and Risk Factors
  • Cardiovascular Disease and Adiposity
  • Hernia repair and management
  • Body Composition Measurement Techniques
  • NMR spectroscopy and applications
  • Photoacoustic and Ultrasonic Imaging
  • Electrical and Bioimpedance Tomography
  • Ultrasound and Hyperthermia Applications

University of California, San Diego
2014-2023

Arizona State University
2023

Universidad Católica Santo Domingo
2020

Massachusetts Institute of Technology
2003-2016

University of California System
2013

Wake Forest University
2006

University of California, Los Angeles
1994-2006

UCLA Health
1993-2005

University Hospital of Wales
2004

West Los Angeles College
1996

OBJECTIVE. MRI provides accurate and high-resolution measurements of cardiac anatomy function. The purpose this study was to describe the imaging protocol normal values left ventricular (LV) function mass in Multi-Ethnic Study Atherosclerosis (MESA). SUBJECTS AND METHODS. Eight hundred participants (400 men, 400 women) four age strata (45–54, 55–64, 65–74, 75–84 years) were chosen at random. Participants with following known cardiovascular risk factors excluded: current smoker, systolic...

10.2214/ajr.04.1868 article EN American Journal of Roentgenology 2006-05-19

To investigate the potential of apparent diffusion coefficients (ADCs) in characterizing breast lesions vivo.Two diffusion-weighted (DW) sequences were implemented on a 1.5 Tesla scanner, with low b-value orthogonal and high tetrahedral sensitized sequences. The sequence was evaluated 16 normal volunteers 23 patients known lesion types (six benign 17 malignant). smaller number subjects: two normal, malignant, benign.The mean value ADC malignant tumors reduced compared to that tissue. This...

10.1002/jmri.10116 article EN Journal of Magnetic Resonance Imaging 2002-05-24

To demonstrate the feasibility of in vivo calf muscle fiber tracking human subjects.An EPI-based diffusion tensor imaging (DTI) sequence with six-direction gradient sensitization was implemented, and DT images were acquired at 3 Tesla on five subjects using an extremity coil. The mean diffusivity, fractional anisotropy (FA), angle (with respect to magnet z-axis) measured different muscles, fibers tracked from several regions interest (ROIs).The orientations current DTI studies agree well...

10.1002/jmri.20593 article EN Journal of Magnetic Resonance Imaging 2006-05-25

In human skeletal muscles, the aging process causes a decrease of contractile and concomitant increase intramuscular adipose (IMAT) connective (IMCT) tissues. The accumulation non-contractile tissues may contribute to significant loss intrinsic muscle strength typically observed at older age but their in vivo quantification is challenging. purpose this study was establish MR imaging-based methods quantify relative amounts IMCT, IMAT young cohorts, investigate roles determining age-associated...

10.1186/1471-2474-15-209 article EN cc-by BMC Musculoskeletal Disorders 2014-06-17

Abstract This article investigates how the internal structure of muscle and its relationship with tendon even skeletal structures influence translation fiber contractions into movement a limb. Reconstructions anatomy human soleus from Visible Human Dataset (available National Library Medicine), magnetic resonance images (MRI), cadaver studies revealed complex 3D connective tissue populated pennate fibers. The posterior aponeurosis median septum form insertion are continuous Achilles tendon....

10.1002/jmor.10421 article EN Journal of Morphology 2006-02-01

Objective: To evaluate the effect of papillary muscle mass on calculation left ventricular (LV) function and to determine relationship between with body size sex. Methods: Cardiac magnetic resonance imaging examinations from 50 men women were randomly selected Multi-Ethnic Study Atherosclerosis database. The contours muscles traced manually, LV wall outlined semiautomatically based short-axis images. Papillary mass, volumes calculated. Results: Inclusion results in significantly higher total...

10.1097/00004728-200605000-00013 article EN Journal of Computer Assisted Tomography 2006-05-01

Abstract The objective of this study was to determine whether linear discriminant analysis different independent features MR images breast lesions can increase the sensitivity and specificity technique. For 23 benign 20 malignant lesions, three classes features, including characteristics Gd‐DTPA‐uptake curve, boundary, texture were evaluated. included five, four eight each, respectively. Discriminant applied both within across classes, find best combination yielding highest classification...

10.1002/jmri.1880070613 article EN Journal of Magnetic Resonance Imaging 1997-11-01

The orientation of muscle fibers influences the physiological cross-sectional area, relationship between fiber shortening and aponeurosis shear, total force produced by muscle. Such architectural parameters are challenging to determine particularly in vivo multicompartment structures such as human soleus with a complex arrangement fibers. objective this study was map architecture at rest both neutral plantarflexed ankle positions using an MRI-based method diffusion tensor imaging (DTI). Six...

10.1152/japplphysiol.00923.2010 article EN Journal of Applied Physiology 2010-12-17

Velocity-encoded phase-contrast magnetic resonance (MR) imaging techniques and a computer-controlled MR-compatible foot pedal device were used to investigate the medial gastrocnemius muscle aponeurosis deformations during passive active eccentric movements of plantarflexors. Intrafascicular strain, measured as ratio strain in fascicle segment at its insertion origin, was nonuniform along proximodistal axis (P < 0.01), progressively increasing from proximal distal direction. The high...

10.1152/japplphysiol.91598.2008 article EN Journal of Applied Physiology 2009-07-16

To investigate age related changes in diffusion tensor indices and fiber architecture of the medial lateral gastrocnemius (MG LG) muscles using imaging (DTI).The lower leg five young senior subjects was scanned at 3 Tesla DTI extracted three methods: region interest, histogram, tract based. Tracked fibers were automatically edited to ensure physiologically relevant tracks. Pennation angles measured with respect deep superficial aponeuroses both muscles.The methods provided internally...

10.1002/jmri.24641 article EN Journal of Magnetic Resonance Imaging 2014-04-28

Abstract This study demonstrates the feasibility of in vivo prostate diffusion tensor imaging (DTI) human subjects. We implemented an EPI‐based diffusion‐weighted (DW) sequence with seven‐direction gradient sensitization, and acquired DT images from six subjects using cardiac gating a phased‐array surface coil operating linear mode. calculated two indices to quantify anisotropy. The direction eigenvector corresponding leading eigenvalue was displayed by means color‐coding scheme. average...

10.1002/mrm.20190 article EN Magnetic Resonance in Medicine 2004-08-23

Purpose The strain rate (SR) tensor measures the principal directions and magnitude of instantaneous deformation; this study aims to track age-related changes in 2D SR medial gastrocnemius during passive joint rotation active isometric contraction. Methods tensors were derived from velocity encoded magnetic resonance phase-contrast images nine young (28 years) eight senior (78 women. Strain rates along cross-section fiber calculated used derive out-plane SR. Age-related regional differences...

10.1002/mrm.25312 article EN Magnetic Resonance in Medicine 2014-07-08

Abstract 2D Janus transition metal dichalcogenides (TMDs) have attracted attention due to their emergent properties arising from broken mirror symmetry and self‐driven polarization fields. While it has been proposed that vdW superlattices hold the key achieving superior in piezoelectricity photovoltaic, available synthesis ultimately limited realization. Here, first packed nanoscrolls made TMDs through a simple one‐drop solution technique are reported. The results, including ab initio...

10.1002/adfm.202303526 article EN publisher-specific-oa Advanced Functional Materials 2023-07-12

It is becoming increasingly apparent that precise knowledge of the anatomic features muscle, aponeurosis, and tendons necessary for understanding how a muscle-tendon complex generates force accomplishes length changes. This report presents both functional data from human soleus muscle acquired by using magnetic resonance imaging. The results show strong relationship between three-dimensional structure system intramuscular distribution tissue velocities during in vivo isometric contractions....

10.1152/japplphysiol.00596.2003 article EN Journal of Applied Physiology 2003-11-01

Hypothesis High-resolution magnetic resonance imaging (MRI) at 1.5 T preferentially enhances the perilymph over endolymph after administration of contrast with gadodiamide, which allows for differentiation membranous labyrinth. Furthermore, this detection endolymphatic hydrops. Background Endolymphatic hydrops is believed to be associated a number ear diseases, including Ménière's disease. Although pathologic changes overaccumulation in inner are obvious on postmortem histologic examination...

10.1097/00129492-200111000-00017 article EN Otology & Neurotology 2001-11-01

Abstract Purpose: To investigate the reproducibility of diffusion tensor imaging (DTI) ‐derived indices and fiber architecture calf muscles at 1.5 Tesla (T), to establish an based method confirm ankle position, compare different positions. Materials Methods: Six subjects were imaged 1.5T with foot in neutral plantarflexed DTI calculated four muscle compartments (medial lateral gastrocnemius [MG, LG], superficial deep anterior tibialis [AT‐S, AT‐D]). Two scanned on 3 days calculate...

10.1002/jmri.22596 article EN Journal of Magnetic Resonance Imaging 2011-05-23

The aim of the present study was to test hypothesis that age-associated decrease tendon stiffness would necessitate greater muscle fascicle strains produce similar levels force during isometric contraction. Greater could sarcomeres operate in less advantageous regions their force-length and force-velocity relationships, thus impairing capacity generate strong explosive contractions. To this hypothesis, sagittal-plane dynamic velocity-encoded phase-contrast magnetic resonance images...

10.1152/japplphysiol.01337.2013 article EN Journal of Applied Physiology 2014-02-07

The external anal sphincter (EAS) may be injured in 25–35% of women during the first and subsequent vaginal childbirths is likely most common cause incontinence. Since its description almost 300 years ago, EAS was believed to a circular or “donut-shaped” structure. Using three-dimensional transperineal ultrasound imaging, MRI, diffusion tensor muscle fiber tracking, we delineated various components their directions. These novel imaging techniques suggest “purse-string” morphology, with “EAS...

10.1152/ajpgi.00338.2013 article EN AJP Gastrointestinal and Liver Physiology 2014-01-24

Implement STEAM-DTI to model time-dependent diffusion eigenvalues using the random permeable barrier (RPBM) study age-related differences in medial gastrocnemius (MG) muscle. Validate model-extracted fiber diameter for histological assessment.

10.1002/nbm.4996 article EN NMR in Biomedicine 2023-07-12
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