A5062145266- Psychopathy, Forensic Psychiatry, Sexual Offending
- Criminal Justice and Corrections Analysis
- Healthcare Decision-Making and Restraints
- Elder Abuse and Neglect
- Down syndrome and intellectual disability research
- Urinary Bladder and Prostate Research
- Radioactive element chemistry and processing
- Autism Spectrum Disorder Research
- Mitochondrial Function and Pathology
- Adipose Tissue and Metabolism
- Urinary Tract Infections Management
- Homelessness and Social Issues
- Diabetes Management and Research
- Attention Deficit Hyperactivity Disorder
- Atherosclerosis and Cardiovascular Diseases
- Radioactive contamination and transfer
- Lipid metabolism and biosynthesis
- Cancer Genomics and Diagnostics
- Crime Patterns and Interventions
- Genomics and Rare Diseases
- Pelvic floor disorders treatments
- Child and Adolescent Psychosocial and Emotional Development
- Radioactivity and Radon Measurements
- Sphingolipid Metabolism and Signaling
- Patient Satisfaction in Healthcare
University of Bristol
2021-2025
Clemson University
2022-2023
University Hospitals Bristol NHS Foundation Trust
2023
University Hospitals Bristol and Weston NHS Foundation Trust
2023
University of Washington
2022
National Health Service
2022
National Institute for Health Research
2022
University of Minnesota
2022
North Bristol NHS Trust
2021
Southmead Hospital
2021
Systems approaches are currently being advocated and implemented to address complex challenges in Public Health. These work by bringing multi-sectoral stakeholders together develop a collective understanding of the system, then identify places where they can leverage change across system. unpredictable, cause-and-effect cannot always be disentangled, unintended consequences - positive negative frequently arise. Evaluating such is difficult new methods warranted.
Lipid phosphate phosphatase 3 (LPP3), encoded by the PPAP2B gene, is an integral membrane enzyme that dephosphorylates, and thereby terminates, G-protein-coupled receptor-mediated signaling actions of lysophosphatidic acid (LPA) sphingosine-1-phosphate. LPP3 essential for normal vascular development in mice, a common polymorphism associated with increased risk coronary artery disease humans. Herein, we investigate function endothelial to understand its role human disease.We developed mouse...
The patterns and pathways into intellectual disability (ID) offender services were studied through case file review for 477 participants referred in one calendar year to community generic, forensic, low, medium, maximum secure services. Data gathered on referral source, demographic information, index behavior, prior problem behaviors, diagnostic abuse or deprivation. Community referrers tended refer service Physical verbal violence the most frequent whereas contact sexual offenses more...
This study was carried out as part of a larger commissioned by the UK Department Health to investigate service pathways for offenders with learning disabilities (LD). The covered three health regions in and included 477 people LD referred services because antisocial or offending behaviour during 12‐month period. Data were collected concerning demographic, individual, characteristics. findings are broadly consistent contemporary research this population, particularly relation nature frequency...
The lipid phosphate phosphatase 3 (LPP3) degrades bioactive lysophospholipids, including lysophosphatidic acid and sphingosine-1-phosphate, thereby terminates their signaling effects. Although emerging evidence links to atherosclerosis vascular injury responses, little is known about the role of LPP3. goal this study was determine LPP3 in development neointima formation smooth muscle cells (SMC) responses.We report that expressed SMC after experimental arterial injury. Using gain-...
Background Developmental and index offence variables have been implicated strongly in later criminal behaviour service pathways this paper investigated attention deficit hyperactivity disorder ( ADHD ) which, with conduct disorder, has emerged from previous studies on offenders. are over‐represented among populations when compared to the general population. The present authors reviewed extent which affected presentation of offenders intellectual disability. Method Information related...
Abstract Provision of health and social support to people who engage in anti-social or offending behaviour have intellectual disabilities (ID) remains a challenge services. Numerous population studies produced contradictory findings with reviews calling for the development more fruitful approaches recommending investigation care pathways operating within ID This study reports on through services encountered by adults referred 15 UK community 2002. Pathways were tracked 24 months post...
Alcohol use and misuse may be lower in people with intellectual disability (ID) than the general population but related to offending.Alcohol-related crime history of alcohol was recorded 477 participants ID referred forensic services offending.Level alcohol-related some previous studies at 5.9% 20.8%, respectively. History abuse associated offences theft. Higher rates problem were histories a number offences, psychiatric disturbance adulthood, childhood, experiences childhood adversity. Most...
Exome sequencing is increasingly utilized in both clinical and nonclinical settings, but little known about its utility healthy individuals. Most previous studies on this topic have examined a small subset of genes to be implicated human disease and/or used automated pipelines assess pathogenicity variants. To determine the frequency medically actionable nonactionable relevant exome findings general population we assessed exomes 70 participants who been extensively characterized over past...
We report on the state of open research data (ORD) policy and practice across UK institutions through STAR (Sustainable & TrAnsparent Research data) project. Through qualitative interviews, focus groups, workshops involving 52 university staff 21 institutions, we investigated progress challenges in ORD practices since 2016 publication Concordat Open Data. observed that while have made establishing specialist roles, developing policies, creating repository infrastructures, systematic...
Objectives To codevelop (with children and young people with diabetes (CYPD)) an intervention to improve control future health outcomes of CYPD from ‘underserved’ groups, reduce treatment outcome inequalities between different socioeconomic ethnic groups. follow Medical Research Council guidance for complex interventions the COM-B (Capability, Opportunity, Motivation, Behaviour) model behaviour change development. Design In phase 1 (previously reported), we established evidence base,...
Although some authors have suggested that there are higher rates of people with Autism Spectrum Disorder (ASD) in forensic and offending groups, systematic studies not supported the hypothesis. The present study reviewed 477 referrals made to intellectual disability (ID) services one calendar year. It was found 10% had ASD, a figure similar general population ID. Those ASD patterns those without but they showed lower prevalence contact sexual offences fewer been previously charged. We...
Abstract Background There is a need for research to promote an understanding among service developers on why people with intellectual disabilities (ID) are referred offender services in order them receive appropriate assessment and treatment. Previous studies investigating referrals into forensic ID have concentrated referral sources administrative variables such as legal status. Aims To construct predictive model choice of based comprehensive range information about the clientele. Method We...
Purpose Following shifts that broadened the medical profession’s conceptualization of underlying drivers health, schools are required to integrate curricula on health disparities and social context medicine into undergraduate education. Although previous research has focused student experiences outcomes in these curricula, less attention been paid physician-faculty involved. This study aimed capture faculty insights improve understanding challenges opportunities implementing this curricular...
Abstract The pathways through services for offenders with intellectual disability were reviewed. Participants 197 accepted into three types of community and secure forensic services. They first compared 280 participants referred but not then followed-up 2 years to review Those had a higher charge rate than did those who (46% 25%, respectively). greatest diversity in pathway was seen inpatient Individuals settings showed the least over time, and, similarly, relatively high percentage generic...
Following social policies of deinstitutionalisation, few offenders with intellectual disability (ID) are diverted into local hospitals and they now referred to a range community secure services. Of 197 participants, the Violence Risk Appraisal Guide was completed on 181 Static-99 83. Assessed risk then related six levels service: generic, specialist forensic ID, learning in patient, low secure, medium high secure. On both assessments, those had significantly greater average assessed than...
Abstract This study compared 131 sex offenders with ID and 346 other types of using case file records. All the females in were non sexual offenders. Significantly more referred from court criminal justice services while significantly fewer secondary healthcare. A higher percentage had some form legal status at time referral. Greater proportions for aggression, damage to property, substance abuse fire setting only an index offence. For previous offending, rates cruelty neglect children,...
While several validated measures of the life circumstances people with intellectual disabilities (ID) have been developed, this stream research has not yet well integrated environmentally oriented criminological theory to explain offending among ID. In study, we attempt provide a preliminary integration through an investigation relationship between contemporary experiences, well-being, choice and ID, exploring relevance two classic theories (theories strain social control).Questionnaire were...
A minority of men and women with intellectual disabilities at times engage in, are suspected, or convicted, illegal activity. Recent policy developments in England Wales emphasise the need to respond appropriately putative offending risk through provision safe effective community management, treatment, support services. In line these concerns, research has focused increasingly on testing utility an evolving variety assessment procedures. Here, authors set out challenge repertoire a number...
Purpose To compare characteristics of sex offenders with an intellectual disability ( ID ) referred to community‐based and different levels secure services. identify those characteristics, which predict referrals or Methods A total 131 cases service in a number health board regions the UK 2002 (and 2003 for high referrals) were reviewed. Data collected on demographic information, ethnicity, level learning disability, possible medical diagnoses, psychiatric abuse experienced childhood, living...
Background Conservative therapies are recommended as initial treatment for male lower urinary tract symptoms. However, there is a lack of evidence on effectiveness and uncertainty regarding approaches to delivery. Objective The objective was determine whether or not standardised manualised care intervention delivered in primary achieves superior symptomatic outcome symptoms usual care. Design This two-arm cluster randomised controlled trial. Setting trial set 30 NHS general practice sites...
Several studies have related diagnostic information and adversity in childhood to criminal careers risk of recidivism. Notably, ADHD conduct disorder childhood, schizophrenia, sexual abuse physical been associated with offences adulthood. This study investigates these variables relation large cohorts offenders learning disabilities. A case note review was undertaken for 126 individuals referred but not accepted into forensic disability services 197 such services. Results are reported on...