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Kyle Troksa

ORCID: 0000-0003-0807-5237
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About
Contact & Profiles
A5000348276
Research Areas
  • DNA Repair Mechanisms
  • Cancer-related Molecular Pathways
  • Mitochondrial Function and Pathology
  • Children's Physical and Motor Development
  • Carcinogens and Genotoxicity Assessment
  • Attention Deficit Hyperactivity Disorder
  • Microtubule and mitosis dynamics

Colorado State University
 2012-2014

 Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress
OPENALEX - Publications 
Shuli Liu Stephen O. Opiyo Karoline C. Manthey Jason G. Glanzer Amanda K. Ashley and 5 more Courtney L. Amerin Kyle Troksa Meena Shrivastav Jac A. Nickoloff Greg G. Oakley

DNA damage encountered by replication forks poses risks of genome destabilization, a precursor to carcinogenesis. Damage checkpoint systems cause cell cycle arrest, promote repair and induce programed death when is severe. Checkpoints are critical parts the response network that act suppress cancer. perturbation machinery causes stress, characterized accumulation single-stranded bound protein A (RPA), which triggers activation ataxia telangiectasia Rad3 related (ATR) phosphorylation RPA32,...

10.1093/nar/gks849 article EN Nucleic Acids Research 2012-09-12
 DNA-PK phosphorylation of RPA32 Ser4/Ser8 regulates replication stress checkpoint activation, fork restart, homologous recombination and mitotic catastrophe
OPENALEX - Publications 
Amanda K. Ashley Meena Shrivastav Jingyi Nie Courtney L. Amerin Kyle Troksa and 9 more Jason G. Glanzer Shengqin Liu Stephen O. Opiyo Diana D. Dimitrova Phuong N. Le Brock J. Sishc Susan M. Bailey Greg G. Oakley Jac A. Nickoloff

10.1016/j.dnarep.2014.04.008 article EN DNA repair 2014-05-10
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