A5048187484- DNA Repair Mechanisms
- Catalysis for Biomass Conversion
- Ammonia Synthesis and Nitrogen Reduction
- Electrocatalysts for Energy Conversion
- DNA and Nucleic Acid Chemistry
- RNA Research and Splicing
- PARP inhibition in cancer therapy
- CRISPR and Genetic Engineering
- Epigenetics and DNA Methylation
- Nanomaterials for catalytic reactions
- Enzyme Catalysis and Immobilization
- Ubiquitin and proteasome pathways
- Microtubule and mitosis dynamics
- Metabolomics and Mass Spectrometry Studies
- Polyoxometalates: Synthesis and Applications
- Cancer, Hypoxia, and Metabolism
- Microbial Metabolic Engineering and Bioproduction
- Histone Deacetylase Inhibitors Research
- Caching and Content Delivery
- Cancer-related gene regulation
- Molecular Biology Techniques and Applications
- Cancer-related Molecular Pathways
- Organic Electronics and Photovoltaics
- Organic Light-Emitting Diodes Research
- Plant nutrient uptake and metabolism
City University of Hong Kong
2024-2025
Northeast Institute of Geography and Agroecology
2025
Chinese Academy of Sciences
2025
University of Chinese Academy of Sciences
2025
University of Nebraska Medical Center
2011-2023
Nanchang University
2019-2020
United Microelectronics (Taiwan)
2019
Nebraska Medical Center
2014
University of Cincinnati
2005
State Key Laboratory on Integrated Optoelectronics
2002
The development of alternative routes for ammonia (NH3) synthesis with high Faradaic efficiency (FE) is crucial energy conservation and to achieve zero carbon emissions. Electrocatalytic nitrate (NO3−) reduction NH3 (e‐NO3RRA) a promising the energy‐intensive, fossil‐fuel‐driven Haber–Bosch process. implementation this innovative technique requires an efficient electrocatalyst in‐depth mechanistic understanding e‐NO3RRA. In study, we developed ultrathin sheet (µm) iron–nickel nanoflower...
The catalytic valorisation of biomass to afford synthetically useful small molecules is essential for sustainable biorefinery processes. Herein, we present a mild cascaded electrochemical protocol converting furoic acid, common biomass-derived feedstock, into versatile platform chemical, gamma-butyrolactone. In the platinum(+)|nickel(-) electrode paired undivided cell, acid electrochemically oxidised with 84.2% selectivity 2(5H)-furanone, olefin which then hydrogenated yield...
The electrochemical selective oxidative transformation of lignin feedstocks into valuable oxygenated aromatics is essential to establish a sustainable biorefinery.
ABSTRACT Low solar radiation is an important factor affecting maize root growth and development. Roots have anchoring function, their components are cellulose lignin. Here, shade experiments were conducted using nets with 50% light transmittance (L 50 ). The experiment was in 2021 2022 the ‘Xianyu 335’ variety under two nitrogen conditions (N 1 = 180 kg ha −1 N 2 240 ) to investigate effect of shading on structural carbohydrate content nodal roots. results showed that had a highly...
The ATR/Chk1 pathway is a critical surveillance network that maintains genomic integrity during DNA replication by stabilizing the forks normal to avoid stress. One of many differences between cells and cancer amount stress occurs replication. Cancer with activated oncogenes generate increased levels This creates an dependency on in opens up opportunity preferentially kill inhibiting this pathway. In support idea, we have identified small molecule termed HAMNO...
The development of alternative routes for ammonia (NH3) synthesis with high Faradaic efficiency (FE) is crucial energy conservation and to achieve zero carbon emissions. Electrocatalytic nitrate (NO3−) reduction NH3 (e‐NO3RRA) a promising the energy‐intensive, fossil‐fuel‐driven Haber–Bosch process. implementation this innovative technique requires an efficient electrocatalyst in‐depth mechanistic understanding e‐NO3RRA. In study, we developed ultrathin sheet (µm) iron–nickel nanoflower...
Replication protein A (RPA), essential for DNA replication, repair and damage signalling, possesses six ssDNA-binding domains (DBDs), including DBD-F on the N-terminus of largest subunit, RPA70. This domain functions as a binding site p53 other proteins that contain amphipathic alpha helical domains. Here, we demonstrate direct both ssDNA transactivation 2 (p53TAD2) to DBD-F, well DBD-F-directed dsDNA strand separation by RPA, all which are inhibited fumaropimaric acid (FPA). FPA binds...
The increasing threat of drug-resistant bacteria establishes a continuing need for the development new strategies to fight infection. We examine inhibition essential single-stranded DNA-binding proteins (SSBs) SSBA and SSBB as potential antimicrobial therapy due their importance in DNA replication, activating SOS response promoting competence-based mechanisms resistance by incorporating DNA. Purified recombinant SSBs from Gram-positive (Staphylococcus aureus Bacillus anthracis) Gram-negative...
Efficient and highly selective production of propionic acid from biomass derived lactic was realized using I<sup>−</sup>/H<sub>2</sub> without adding other strong acids or metal catalysts.
Glyceric acid was reduced selectively to 3-iodopropionic at 373 K by hydroiodic mediated rhodium and hydrogen.
Cells respond to DNA double-strand breaks by initiating DSB repair and ensuring a cell cycle checkpoint. The primary responder is non-homologous end joining, which an error-prone pathway. However, when DSBs are generated after replication in the G2 phase of cycle, second pathway, homologous recombination, can come into action. Both ATM ATR important for DSB-induced checkpoint responses. One method working together through resection DSBs. As readout marker resection, RPA phosphorylated at...
Oral cancers are easily accessible compared to many other cancers. Nevertheless, oral cancer is often diagnosed late, resulting in a poor prognosis. Most squamous cell carcinomas that predominantly develop from hyperplasias and dysplasias. DNA damage induced these tissues directly or indirectly response oncogene-induced deregulation of cellular proliferation. Consequently, Damage (DDR) cycle checkpoint activated. As dysplasia transitions cancer, proteins involved signaling mutated silenced...
In advanced FinFET devices, STI gap fill and <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$\vert \text{LD}_{0}$</tex> stress are responsible for fin defects, bending as well device performance degradations due to the local layout effect (LLE). this paper, first time, we look at different ways modulate from Flowable CVD (FCVD) films either by additional UV treatment and/or ion beam (hot Helium implantation). By leveraging in-line e-beam...
As an important biomass-derived chemical, d-sorbitol can be converted to a variety of useful chemicals and fuels. Because the strong nucleophilicity I– reducibility hydrogen iodide (HI), hydroiodic acid has been used for polyol hydrogenolysis with high selectivity. Here, was by HI, rhodium, give yield iodohexanes (94.2%) at 373 K in water/cyclohexane biphasic system. Rhodium were regenerate HI situ. The reaction mechanism studied detail using model molecules....
Maintenance of genome integrity is critical for proper cell growth. This occurs through accurate DNA replication and repair lesions. A key factor involved in both the damage response heterotrimeric single-stranded (ssDNA) binding complex Replication Protein (RPA). Although RPA appears to be structurally conserved throughout eukaryotes, primary amino acid sequence each subunit can vary considerably. Examination differences along with functional interchangeability orthologous subunits or...
Cells respond to DNA double-strand breaks by initiating DSB repair and ensuing a cell cycle checkpoint. The primary responder is non-homologous end joining, an error prone pathway. However, when DSBs are generated after replication in the G2 phase of cycle, second pathway, homologous recombination, can come into action. Both ATM ATR important for DSB-induced checkpoint responses. One method working together through end-resection DSBs. As readout marker end-resection, RPA phosphorylated at...
An efficient catalytic method to transform biomass into value-added products is critical promoting a sustainable future. Ideally, such transformation should be carried out efficiently in mild conditions. Herein, we developed one-pot electrochemical protocol for converting furoic acid (FA), common biomass-derived feedstock, versatile platform chemical, gamma-butyrolactone (GBL). All involved species participate the desired redox pathway with high selectivity: FA was electrochemically oxidized...
The catalytic valorization of biomass to afford synthetically useful small molecules is essential for sustainable biorefinery processes. Herein, we present a mild cascaded electrochemical protocol converting furoic acid (FA), common biomass-derived feedstock, into versatile platform chemical, gamma-butyrolactone (GBL). All involved species participate in the desired redox pathway with high selectivity: FA was electrochemically oxidized 84.2% selectivity 2(5H)-furanone (2-FO), olefin which...
Replication protein A (RPA) is a heterotrimer, single strand DNA binding involved in multiple aspects of metabolism. The N‐terminus the RPA2 subunit phosphorylated at sites during cell cycle progression and response to damage. To understand role phosphorylation, we generated stable lines expressing wild‐type mutant forms RPA with down regulation endogenous by shRNA. inability phosphorylate Ser4 Ser8 resulted loss phosphorylation Ser12 Thr21, but not Ser33 etoposide treatment. Cells showed...