A5063045793- Spectroscopy and Laser Applications
- Atmospheric Ozone and Climate
- Photonic and Optical Devices
- Semiconductor Lasers and Optical Devices
- Semiconductor Quantum Structures and Devices
- Analytical Chemistry and Sensors
- Laser Design and Applications
- Advanced biosensing and bioanalysis techniques
- Molecular Junctions and Nanostructures
- Optical properties and cooling technologies in crystalline materials
- Terahertz technology and applications
- Atmospheric and Environmental Gas Dynamics
- Advanced Semiconductor Detectors and Materials
- Conducting polymers and applications
- Advanced Fiber Laser Technologies
- Chalcogenide Semiconductor Thin Films
- Gas Sensing Nanomaterials and Sensors
- Quantum Dots Synthesis And Properties
- Semiconductor materials and devices
- Mechanical and Optical Resonators
- Organic Electronics and Photovoltaics
- Laser Material Processing Techniques
- Nanowire Synthesis and Applications
- Semiconductor materials and interfaces
- Atmospheric chemistry and aerosols
University of Bari Aldo Moro
2016-2025
Istituto Nanoscienze
2024-2025
Istituto di Fotonica e Nanotecnologie
2014-2024
Scuola Normale Superiore
2024
Center for Biomolecular Nanotechnologies
2023
Consorzio Interuniversitario per lo Sviluppo dei Sistemi a Grande Interfase
2019-2023
Istituto Nazionale di Fisica Nucleare, Sezione di Bari
2010-2022
Polytechnic University of Bari
2011-2022
Merlin Circuit Technology (United Kingdom)
2020
Consorzio Interuniversitario Fisica Spaziale
2017
Label-free single-molecule detection has been achieved so far by funnelling a large number of ligands into sequence single-binding events with few recognition elements host on nanometric transducers. Such approaches are inherently unable to sense cue in bulk milieu. Conceptualizing cells' ability at the physical limit means highly-packed elements, millimetric sized field-effect-transistor is used detect single molecule. To this end, gate bio-functionalized self-assembled-monolayer 1012...
A sensitive spectroscopic sensor based on a hollow-core fiber-coupled quantum cascade laser (QCL) emitting at 10.54 μm and quartz enhanced photoacoustic spectroscopy (QEPAS) technique is reported. The design realization of mid-IR fiber coupler optics has ensured single-mode QCL beam delivery to the QEPAS sensor. collimation was designed produce significantly reduced size waist so as prevent illumination tuning fork microresonator tubes. SF6 selected target gas. minimum detection sensitivity...
We report on a spectroscopic technique named intracavity quartz-enhanced photoacoustic spectroscopy (I-QEPAS) employed for sensitive trace-gas detection in the mid-infrared spectral region. It is based combination of QEPAS with buildup optical cavity. The sensor includes distributed feedback quantum cascade laser emitting at 4.33 μm. achieved power factor ∼500, which corresponds to an ∼0.75 W. CO2 has been selected as target molecule I-QEPAS demonstration. sensitivity 300 parts per trillion...
Abstract Organic bioelectronic sensors are gaining momentum as they can combine high‐performance sensing level with flexible large‐area processable materials. This opens to potentially highly powerful systems for point‐of‐care health monitoring and diagnostics at low cost. Prominent detect biochemical recognition events, electrolyte‐gated organic field‐effect transistors (EGOFETs) electrochemical (OECTs) easily fabricated operated. EGOFETs recently shown be capable of label‐free...
A quartz enhanced photo-acoustic sensor employing a single-mode quantum cascade laser emitting at 3.93 Terahertz (THz) is reported. custom tuning fork with 1 mm spatial separation between the prongs allows focusing of THz beam them, while preventing illumination. methanol transition line-strength 4.28 × 10−21 cm has been selected as target spectroscopic line. At optical power ∼ 40 μW, we reach sensitivity 7 parts per million in 4s integration time, corresponding to 1σ normalized...
Biosystems integration into an organic field-effect transistor (OFET) structure is achieved by spin coating phospholipid or protein layers between the gate dielectric and semiconductor. An architecture directly interfacing supported biological to OFET channel proposed and, strikingly, both electronic properties biointerlayer functionality are fully retained. The platform bench tests involved OFETs integrating phospholipids bacteriorhodopsin exposed 1-5% anesthetic doses that reveal...
A systematic comparison between electrochemical and organic bioelectronic sensors reveals a unified rational description for transistor amplified detection.
A compact widely-tunable fiber-coupled sensor for trace gas detection of hydrogen sulfide (H₂S) in the mid infrared is reported. The based on an external-cavity quantum cascade laser (EC-QCL) tunable between 7.6 and 8.3 μm wavelengths coupled into a single-mode hollow-core waveguide. Quartz-enhanced photoacoustic spectroscopy has been selected as detecting technique. fiber coupling system converts astigmatic beam exiting TEM(00) mode. During full scan, we observed no misalignment optical...
An innovative quartz enhanced photoacoustic (QEPAS) gas sensing system operating in the THz spectral range and employing a custom tuning fork (QTF) is described. The QTF dimensions are 3.3 cm × 0.4 0.8 cm, with two prongs spaced by ∼800 μm. To test our sensor we used quantum cascade laser as light source selected methanol rotational absorption line at 131.054 cm(-1) (∼3.93 THz), line-strength S = 4.28 10(-21) mol(-1). was operated 10 Torr pressure on first flexion resonance frequency of 4245...
We study the time dependence of optical power emitted by terahertz and mid-IR quantum cascade lasers in presence reinjection demonstrate unprecedented continuous wave (CW) emission stability for strong feedback. show that absence coherence collapse or other CW instabilities typical diode is inherently associated with high value photon to carrier lifetime ratio negligible linewidth enhancement factor lasers.
We report here on the use of Allan deviation plot to analyze long-term stability a quartz-enhanced photoacoustic (QEPAS) gas sensor. The provides information about optimum averaging time for QEPAS signal and allows prediction its ultimate detection limit. can also be used determine main sources noise coming from individual components Quartz tuning fork thermal dominates integration times up 275 s, whereas at longer times, contribution sensor originates laser power instabilities.
At terahertz (THz) frequencies, scattering-type scanning near-field optical microscopy (s-SNOM) based on continuous wave sources mostly relies cryogenic and bulky detectors, which represents a major constraint for its practical application. Here, we devise THz s-SNOM system that provides both amplitude phase contrast achieves nanoscale (60-70nm) in-plane spatial resolution. It features quantum cascade laser simultaneously emits frequency light senses the backscattered field through voltage...
In the last decade, saliva has been suggested as non-invasive diagnostic fluid, suitable for clinical use alternatively to blood serum and plasma. However, applicability of hampered so far by inadequate sensitivity current methods detect lower salivary concentrations many biomarkers monitored in products. Herein, a label-free biosensor based on electrolyte-gated organic thin-film transistor (EGOTFT) developed detection at physical limit C-reactive protein (CRP) human saliva. CRP is key...
The increasing interest in technologies capable of tracking a biomarker down to the physical limit points toward new opportunities early diagnostics progressive diseases. Indeed, single-molecule detection are foreseen enable clinicians associate tiniest increase with progression disease, particularly at its stage. Bioelectronic organic transistors represent an extremely powerful tool achieve label-free and clinically relevant biomarkers. These electronic devices millimetric size future could...
Near-field microscopy discloses a peculiar potential to explore novel quantum state of matter at the nanoscale, providing an intriguing playground investigate, locally, carrier dynamics or propagation photoexcited modes as plasmons, phonons, plasmon-polaritons phonon-polaritons. Here, we exploit combination hyperspectral time domain spectroscopy nano-imaging and detectorless scattering near-field optical microscopy, multiple terahertz frequencies, rich physics layered topological insulators...
Abstract A cohort of 47 patients is screened for pancreatic cancer precursors with a portable 96‐well bioelectronic sensing‐array single‐molecule assay in cysts fluid and blood plasma, deployable at point‐of‐care (POC). Pancreatic are mucinous diagnosed sensitivity most 80% by state‐of‐the‐art cytopathological molecular analyses (e.g., KRAS mut DNA). Adding the simultaneous proteins related to malignant transformation MUC1 CD55) deemed essential enhance diagnostic accuracy. The array...
Abstract Screening asymptomatic organisms (humans, animals, plants) with a high‐diagnostic accuracy using point‐of‐care‐testing (POCT) technologies, though still visionary holds great potential. Convenient surveillance requires easy‐to‐use, cost‐effective, ultra‐portable but highly reliable, in‐vitro‐diagnostic devices that are ready for use wherever they needed. Currently, there not yet such available on the market, couple more promising technologies developed at readiness‐level 5:...
A quantum-cascade long-wavelength infrared laser based on superlattice active regions has been demonstrated. In this source, electrons injected by tunneling emit photons corresponding to the energy gap (minigap) between two conduction bands (minibands). distinctive design feature is high oscillator strength of optical transition. Pulsed operation at a wavelength about 8 micrometers with peak powers ranging from approximately 0.80 watt 80 kelvin 0.2 200 demonstrated in 1-nanometer-thick...
We demonstrate that ${\mathrm{CdS}}_{1\mathrm{\ensuremath{-}}\mathit{x}}$${\mathrm{Se}}_{\mathit{x}}$ nanocrystals embedded in glass suffer compressive strain which increases as the crystallite radius decreases. A model based on dependence of cluster surface free energy surface-to-volume ratio explains very well observed blueshift phonon bands Raman spectra.
An increase in the Fr\"ohlich-electron-LO-phonon interaction strength with decreasing nanocrystal size strong confinement limited is reported. This results from dependence of resonant Raman scattering by $\mathrm{Cd}{\mathrm{S}}_{x}{\mathrm{Se}}_{1\ensuremath{-}x}$ nanocrystals embedded a glass slab. The mean particle radius $20<\overline{R}<30$ \AA{} increases monotonically position along slab so that, for each laser line, resonance has been tuned scanning sample microprobe. relative...
We compare the electronic temperatures and population inversion both below above lasing threshold in three quantum-cascade lasers (QCLs) operating at 2.8THz, 3.2THz, 3.8THz using microprobe band-to-band photoluminescence. In range, while ground-state temperature remains close to lattice one (90K–100K), upper radiative state heats up ∼200K. From measured thermal resistance power dependence of temperature, we get a value electron-lattice energy relaxation rate comparable with that typical...