A5031109920- IL-33, ST2, and ILC Pathways
- Gut microbiota and health
- Parasites and Host Interactions
- Eosinophilic Esophagitis
- Digestive system and related health
- Parasitic Infections and Diagnostics
- Cancer Cells and Metastasis
- Invertebrate Immune Response Mechanisms
- Hippo pathway signaling and YAP/TAZ
- Epigenetics and DNA Methylation
- Helicobacter pylori-related gastroenterology studies
- Reproductive System and Pregnancy
- Immune responses and vaccinations
- Immune Cell Function and Interaction
- Macrophage Migration Inhibitory Factor
- Tissue Engineering and Regenerative Medicine
- Cancer Research and Treatments
Norwegian University of Science and Technology
2020-2024
The intestinal tract is a common site for various types of infections including viruses, bacteria, and helminths, each requiring specific modes immune defense. epithelium has pivotal role in both initiation effector stages, which are coordinated by lymphocyte cytokines such as IFNγ, IL-13, IL-22. Here, we studied epithelial responses using organoid image analysis based on convolutional neural network, transcriptomic analysis, vivo infection models. We found that IL-13 IL-22 induce genes...
Abstract Smooth muscle is an essential component of the intestine, both to maintain its structure and produce peristaltic segmentation movements. However, very little known about other putative roles that smooth cells may have. Here, we show be dominant suppliers BMP antagonists, which are niche factors for intestinal stem cell maintenance. Furthermore, muscle-derived render epithelium reparative fetal-like, includes heightened YAP activity. Mechanistically, find membrane-bound matrix...
How helminths influence the pathogenesis of sexually transmitted viral infections is not comprehensively understood. Here, we show that an acute helminth infection (Nippostrongylus brasiliensis [Nb]) induced a type 2 immune profile in female genital tract (FGT). This leads to heightened epithelial ulceration and pathology subsequent herpes simplex virus (HSV)-2 infection. was IL-5-dependent but IL-4 receptor alpha (Il4ra) independent, associated with increased FGT eosinophils, raised vaginal...
Infectious and inflammatory diseases in the intestine remain a serious threat for patients world-wide. Reprogramming of intestinal epithelium towards protective effector state is important to manage inflammation immunity can be therapeutically targeted. The role epigenetic regulatory enzymes within these processes not yet defined. Here, we use mouse model that has an intestinal-epithelial specific deletion histone demethylase Lsd1 (cKO mice), which maintains fixed reparative state. Challenge...
Postnatal development of the gastrointestinal tract involves establishment commensal microbiota, acquisition immune tolerance via a balanced cell composition, and maturation intestinal epithelium. While studies have uncovered an interplay between first two, less is known about role maturing Here we show that intestinal-epithelial intrinsic expression lysine-specific demethylase 1A (LSD1) necessary for postnatal epithelium maintenance this developed state during adulthood. Using...
Intestinal epithelial homeostasis is maintained by intrinsic and extrinsic signals. The signals include those provided mesenchymal cell populations that surround intestinal crypts further facilitated the extracellular matrix (ECM), which modulated proteases such as metalloproteinases (MMPs). Extrinsic ensure an appropriate balance between proliferation differentiation. This study explores role of MMP17, preferentially expressed smooth muscle cells in intestine, during immunity to infection....
SUMMARY Smooth muscle is an essential component of the intestine, both to maintain its structure and produce peristaltic segmentation movements. However, very little known about other putative roles that smooth may have. Here, we show dominant supplier BMP antagonists, which are niche factors for intestinal stem cell maintenance. Furthermore, muscle-derived can render epithelium reparative fetal-like, includes heightened YAP activity. Mechanistically, find matrix metalloproteinase MMP17,...
ABSTRACT Intestinal epithelial homeostasis is maintained by intrinsic and extrinsic signals. The signals include those provided mesenchymal cell populations that surround intestinal crypts further facilitated the extracellular matrix (ECM), which modulated proteases such as metalloproteinases (MMPs). Extrinsic ensure an appropriate balance between proliferation differentiation. This study explores role of MMP17, expressed cells, in during immunity to infection. Mice lacking MMP17 high levels...
ABSTRACT Postnatal development of the gastrointestinal tract involves establishment commensal microbiota, maturation intestinal epithelium, and acquisition immune tolerance via a balanced cell composition. While studies have uncovered an interplay between microbiota system development, less is known about role maturing epithelium. Here, we comprehensively show that intestinal-epithelial intrinsic expression lysine-specific demethylase 1A (LSD1) necessary for postnatal epithelium as well...