A5005003317- Heat shock proteins research
- vaccines and immunoinformatics approaches
- Marine Biology and Environmental Chemistry
- Leptospirosis research and findings
- Mitochondrial Function and Pathology
- Cellular Mechanics and Interactions
- Protein Structure and Dynamics
- Alzheimer's disease research and treatments
- Plant Virus Research Studies
- Biochemical effects in animals
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Glutathione Transferases and Polymorphisms
- Bacteriophages and microbial interactions
- Force Microscopy Techniques and Applications
- NF-κB Signaling Pathways
- Ubiquitin and proteasome pathways
- Immunotherapy and Immune Responses
Utrecht University
2019-2025
Kansas State University
2014
The chaperone Hsp90 remodels the structural ensemble of Tau, resulting in formation potentially neurotoxic oligomers.
The pathogenesis of many inflammatory diseases is associated with the uncontrolled activation nuclear factor kappa B (NF-κB) in macrophages. Previous studies have shown that various cell types, heat shock protein 70 (Hsp70) plays a crucial role controlling NF-κB activity. So far, little known about Hsp70 canine processes. In this study we investigated potential anti-inflammatory effects macrophages as well mechanisms underlying these effects. To end, macrophage line was stressed arsenite,...
Here, we develop PEPSeek, a web-server based software to allow higher performance in the identification of pathogen-derived epitope candidates detected via mass spectrometry MHC class I immunopeptidomes. We apply it human and mouse cell lines infected with either SARS-CoV-2, Listeria monocytogenes or Chlamydia trachomatis, thereby identifying large number novel antigens epitopes that prove be recognized by CD8+ T cells. In cells, identified antigenic peptide features suggested how processing...
Notch signaling in metazoans is responsible for key cellular processes related to embryonic development and tissue homeostasis. Proteolitic cleavage of the S2 site within an extracellular NRR domain a early event signaling. We use single molecule force-extension (FX) atomic force microscopy (AFM) study force-induced exposure from mouse 1. Our FX AFM measurements yield histogram N-to-C termini lengths, which we relate conformational transitions domain. detect four classes such transitions....
Abstract Aggregation of the microtubule-associated protein Tau is a hallmark Alzheimer’s disease with oligomers suspected as most toxic agent. client Hsp90, though it unclear whether and how chaperone massages structure intrinsically disordered Tau. Using electron paramagnetic resonance, we extract structural information from very broad conformational ensemble Tau: in solution highly dynamic polymorphic, ‘paper-clip’-shaped by long-range contacts. Interaction Hsp90 promotes an open...