A5083230743- Nanoparticles: synthesis and applications
- Environmental Toxicology and Ecotoxicology
- Carcinogens and Genotoxicity Assessment
- Toxic Organic Pollutants Impact
- Pesticide Exposure and Toxicity
- Effects and risks of endocrine disrupting chemicals
- Reproductive Biology and Fertility
- Pesticide and Herbicide Environmental Studies
- Sperm and Testicular Function
- Graphene and Nanomaterials Applications
- Neurobiology and Insect Physiology Research
- Anesthesia and Neurotoxicity Research
- Drug Transport and Resistance Mechanisms
- Animal Ecology and Behavior Studies
- Marine Biology and Environmental Chemistry
- DNA and Nucleic Acid Chemistry
- Physiological and biochemical adaptations
- Microplastics and Plastic Pollution
- Invertebrate Immune Response Mechanisms
- Birth, Development, and Health
- Pharmacogenetics and Drug Metabolism
- Gut microbiota and health
- Animal testing and alternatives
- Lipid Membrane Structure and Behavior
- Cholinesterase and Neurodegenerative Diseases
University of Milano-Bicocca
2015-2025
Azienda Ospedaliera San Gerardo
2022
Bar-Ilan University
2015
Bentham Science Publishers (China)
2013
Bentham Science Publishers (United Arab Emirates)
2013
University of Milan
1985-2009
Ambiente Italia (Italy)
1998
Microplastic pollution represents a global problem with negative impacts on aquatic environment and organisms' health. To date, most of the laboratory toxicological studies microplastics (MPs) have made use single commercial micro nano-polymers, which do not reflect heterogeneity environmental MPs. improve relevance hazard assessment, micrometer-sized plastic particles miscellaneous non-reusable waste plastics, size <100 µm <50 (waste microplastics, wMPs), were characterized by microscopic...
The green and safe polymer HEC confers bio-interactive properties to Ag-Nps that, together with the small size positive ζ potential, increase their biological reactivity towards zebrafish embryos.
Nanomaterials (NMs), including nanoparticles (NPs), offer promising potential in achieving the European Commission's Green Deal goals of climate-neutral, zero-pollution and circular economy. Metal oxide NPs display antimicrobial properties, with efficacy also towards antimicrobial-resistant bacteria. Nevertheless, increasing manufacture, use unintended release NMs particularly aquatic compartments, raises concerns about their environmental sustainability safety non-target organisms. Within...
We have previously shown that the endogenous lipid palmitoylethanolamide (PEA) induced relief of neuropathic pain through an action upon receptors located on nociceptive pathway. Recently, it has been proposed immune cells, in particular mast and microglia, by releasing algogen mediators interact with neurons to alter sensitivity thereby contributing development maintenance chronic states. The aim this work was explore whether anti-nociceptive properties PEA might be accompanied modulation...
Microplastics (MPs) represent a worldwide emerging relevant concern toward human and environmental health due to their intentional or unintentional release. Human exposure MPs by inhalation is predicted be among the most hazardous. include both engineered, primary MPs, secondary materials obtained fragmentation from any plastic good. The major part of constituted second ones that are irregular in size, shape composition. These features make study biological impact heterogenous extremely high...
During the twenty-first century, engineered nanomaterials (ENMs) have attracted rising interest, globally revolutionizing all industrial sectors. The expanding world population and implementation of new global policies are increasingly pushing society toward a bioeconomy, focused on fostering adoption bio-based that functional, cost-effective, potentially secure to be implied in different areas, medical field included. This research was silica nanoparticles (SiO2-NPs) synthetic origin....
The increased resistances to conventional antibiotics determine a strong need for new antibacterials, and specific syntheses at the nanoscale promise be helpful in this field. A novel Zinc-doped Copper oxide nanocomposite (nZn-CuO) has been recently sonochemically synthesized successfully tested also against multi-drug resistant bacteria. After synthesis characterization of physicochemical properties, nZn-CuO is here evaluated by Frog Embyo Teratogenesis Assay-Xenopus test its toxicological...
The growing global production of zinc oxide nanoparticles (ZnONPs) suggests a realistic increase in the environmental exposure to such nanomaterial, making knowledge its biological reactivity and safe-by-design synthesis mandatory. In this study, embryotoxicity ZnONPs (1–100 mg/L) specifically synthesized for industrial purposes with different sizes, shapes (round, rod) surface coatings (PEG, PVP) was tested using frog embryo teratogenesis assay-Xenopus (FETAX) identify potential target...
The antibacterial activity of metal oxide (MeO) nanoparticles (NPs) has been extensively reported. Nevertheless, there is a general concern about MeO NPs toxicity, and much efforts are being devoted to improve safe employment these nanomaterials by surface functionalization. In this work, we propose investigate if the coating copper zinc oxides (CuO ZnO) with polymers poly(ethylene imine) (PEI) or glycol) (PEG) able protect non-target cells organisms from toxicity MeOs NPs. overall results...
Iron nanoparticles (NPs) have been proposed as a tool in very different fields such environmental remediation and biomedical applications, including food fortification against iron deficiency, even if there is still concern about their safety. Here, we propose Xenopus laevis embryos suitable model to investigate the toxicity bio-interactions at intestinal barrier of Fe3O4 zerovalent (ZVI) NPs compared Fe(II) (III) salts 5 100 mg Fe/L concentration range using Frog Embryo Teratogenesis Assay...
Silver nanoparticles (AgNPs) are among the most exploited antimicrobial agents and used in many consumer products. Size surface reactivity critical physico-chemical properties responsible for NPs toxicity, coatings, often to functionalize or stabilize AgNPs, can influence their toxic profile biocompatibility. In current study developmental toxicity of (1) negatively charged citrate-coated AgNPs (Cit-AgNPs), (2) positively branched polyethylenimine-coated (BPEI-AgNPs), (3) Ag+ (from 0.0625...
ABSTRACT A potassium- or sodium-activated cotransport of leucine occurs in brush-border membrane vesicles prepared from the midgut larvae Philosamia cynthia (Drury). The potassium chemical gradient can drive a twofold accumulation leucine, which is greatly increased under experimental conditions that presumably provide an electrical potential difference (Δ ψ). Kinetic parameters show transport improved by these and pH similar to occurring vivo. However, gradients cannot intravesicular...
ABSTRACT Amino acid accumulation within brush-border membrane vesicles (BBMV) from the larval midgut of Lepidoptera is driven by a K+ gradient. However, it can also be Na+ gradient, although with reduced efficiency. To examine possibility that sodium and potassium ions are handled same amino transporter, glycine uptake into BBMV Philosamia cynthia Drury was measured in presence pH gradient transmembrane electrical potential difference, i.e. simulated ‘physiological’ conditions. The kinetics...
Perinatal polychlorinated biphenyl (PCB) exposures still remain a serious health concern because offspring receive PCB burden from mother during vulnerable processes of development. Since cytochrome P450 (CYP) represents toxicological endpoint, in the present study, representing an extended investigation previous multitasked one, we explored long-term responsiveness CYP1A and CYP2B isoforms by Western blot analysis liver whole brain lactating (PN12), weaning (PN21), adult (PN60) rats...